Transcriptional activator Myb
Details
- Name
- Transcriptional activator Myb
- Synonyms
- Proto-oncogene c-Myb
- Gene Name
- MYB
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0006771|Transcriptional activator Myb MARRPRHSIYSSDEDDEDFEMCDHDYDGLLPKSGKRHLGKTRWTREEDEKLKKLVEQNGT DDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIAK HLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNA IKNHWNSTMRRKVEQEGYLQESSKASQPAVATSFQKNSHLMGFAQAPPTAQLPATGQPTV NNDYSYYHISEAQNVSSHVPYPVALHVNIVNVPQPAAAAIQRHYNDEDPEKEKRIKELEL LLMSTENELKGQQVLPTQNHTCSYPGWHSTTIADHTRPHGDSAPVSCLGEHHSTPSLPAD PGSLPEESASPARCMIVHQGTILDNVKNLLEFAETLQFIDSFLNTSSNHENSDLEMPSLT STPLIGHKLTVTTPFHRDQTVKTQKENTVFRTPAIKRSILESSPRTPTPFKHALAAQEIK YGPLKMLPQTPSHLVEDLQDVIKQESDESGIVAEFQENGPPLLKKIKQEVESPTDKSGNF FCSHHWEGDSLNTQLFTQTSPVADAPNILTSSVLMAPASEDEDNVLKAFTVPKNRSLASP LQPCSSTWEPASCGKMEEQMTSSSQARKYVNAFSARTLVM
- Number of residues
- 640
- Molecular Weight
- 72340.675
- Theoretical pI
- 6.82
- GO Classification
- FunctionsRNA polymerase II core promoter proximal region sequence-specific DNA binding / transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingProcessesB cell differentiation / blood coagulation / calcium ion transport / cellular response to interleukin-6 / chromatin remodeling / embryonic digestive tract development / G1/S transition of mitotic cell cycle / homeostasis of number of cells / in utero embryonic development / myeloid cell differentiation / negative regulation of transcription from RNA polymerase II promoter / negative regulation of transcription, DNA-templated / positive regulation of histone H3-K4 methylation / positive regulation of histone H3-K9 methylation / positive regulation of T-helper cell differentiation / positive regulation of transcription from RNA polymerase II promoter / positive regulation of transcription, DNA-templated / regulation of transcription, DNA-templated / spleen development / stem cell division / thymus developmentComponentscytosol / nuclear matrix
- General Function
- Transcriptional activator activity, rna polymerase ii core promoter proximal region sequence-specific binding
- Specific Function
- Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0012437|Transcriptional activator Myb (MYB) ATGGCCCGAAGACCCCGGCACAGCATATATAGCAGTGACGAGGATGATGAGGACTTTGAG ATGTGTGACCATGACTATGATGGGCTGCTTCCCAAGTCTGGAAAGCGTCACTTGGGGAAA ACAAGGTGGACCCGGGAAGAGGATGAAAAACTGAAGAAGCTGGTGGAACAGAATGGAACA GATGACTGGAAAGTTATTGCCAATTATCTCCCGAATCGAACAGATGTGCAGTGCCAGCAC CGATGGCAGAAAGTACTAAACCCTGAGCTCATCAAGGGTCCTTGGACCAAAGAAGAAGAT CAGAGAGTGATAGAGCTTGTACAGAAATACGGTCCGAAACGTTGGTCTGTTATTGCCAAG CACTTAAAGGGGAGAATTGGAAAACAATGTAGGGAGAGGTGGCATAACCACTTGAATCCA GAAGTTAAGAAAACCTCCTGGACAGAAGAGGAAGACAGAATTATTTACCAGGCACACAAG AGACTGGGGAACAGATGGGCAGAAATCGCAAAGCTACTGCCTGGACGAACTGATAATGCT ATCAAGAACCACTGGAATTCTACAATGCGTCGGAAGGTCGAACAGGAAGGTTATCTGCAG GAGTCTTCAAAAGCCAGCCAGCCAGCAGTGGCCACAAGCTTCCAGAAGAACAGTCATTTG ATGGGTTTTGCTCAGGCTCCGCCTACAGCTCAACTCCCTGCCACTGGCCAGCCCACTGTT AACAACGACTATTCCTATTACCACATTTCTGAAGCACAAAATGTCTCCAGTCATGTTCCA TACCCTGTAGCGTTACATGTAAATATAGTCAATGTCCCTCAGCCAGCTGCCGCAGCCATT CAGAGACACTATAATGATGAAGACCCTGAGAAGGAAAAGCGAATAAAGGAATTAGAATTG CTCCTAATGTCAACCGAGAATGAGCTAAAAGGACAGCAGACACAGAACCACACATGCAGC TACCCCGGGTGGCACAGCACCACCATTGCCGACCACACCAGACCTCATGGAGACAGTGCA CCTGTTTCCTGTTTGGGAGAACACCACTCCACTCCATCTCTGCCAGCGGATCCTGGCTCC CTACCTGAAGAAAGCGCCTCGCCAGCAAGGTGCATGATCGTCCACCAGGGCACCATTCTG GATAATGTTAAGAACCTCTTAGAATTTGCAGAAACACTCCAATTTATAGATTCTTTCTTA AACACTTCCAGTAACCATGAAAACTCAGACTTGGAAATGCCTTCTTTAACTTCCACCCCC CTCATTGGTCACAAATTGACTGTTACAACACCATTTCATAGAGACCAGACTGTGAAAACT CAAAAGGAAAATACTGTTTTTAGAACCCCAGCTATCAAAAGGTCAATCTTAGAAAGCTCT CCAAGAACTCCTACACCATTCAAACATGCACTTGCAGCTCAAGAAATTAAATACGGTCCC CTGAAGATGCTACCTCAGACACCCTCTCATCTAGTAGAAGATCTGCAGGATGTGATCAAA CAGGAATCTGATGAATCTGGAATTGTTGCTGAGTTTCAAGAAAATGGACCACCCTTACTG AAGAAAATCAAACAAGAGGTGGAATCTCCAACTGATAAATCAGGAAACTTCTTCTGCTCA CACCACTGGGAAGGGGACAGTCTGAATACCCAACTGTTCACGCAGACCTCGCCTGTGGCA GATGCACCGAATATTCTTACAAGCTCCGTTTTAATGGCACCAGCATCAGAAGATGAAGAC AATGTTCTCAAAGCATTTACAGTACCTAAAAACAGGTCCCTGGCGAGCCCCTTGCAGCCT TGTAGCAGTACCTGGGAACCTGCATCCTGTGGAAAGATGGAGGAGCAGATGACATCTTCC AGTCAAGCTCGTAAATACGTGAATGCATTCTCAGCCCGGACGCTGGTCATGTGA
- Chromosome Location
- 6
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P10242 UniProtKB Entry Name MYB_HUMAN GenBank Gene ID M13666 GenAtlas ID MYB HGNC ID HGNC:7545 - General References
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