COUP transcription factor 1
Details
- Name
- COUP transcription factor 1
- Synonyms
- COUP transcription factor I
- COUP-TF I
- COUP-TF1
- EAR-3
- EAR3
- ERBAL3
- Nuclear receptor subfamily 2 group F member 1
- TFCOUP1
- V-erbA-related protein 3
- Gene Name
- NR2F1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0049622|COUP transcription factor 1 MAMVVSSWRDPQDDVAGGNPGGPNPAAQAARGGGGGAGEQQQQAGSGAPHTPQTPGQPGA PATPGTAGDKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTY TCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPNPGQYALTNGDPLN GHCYLSGYISLLLRAEPYPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFF PDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIR IFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQY PNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMSI QCS
- Number of residues
- 423
- Molecular Weight
- 46155.24
- Theoretical pI
- Not Available
- GO Classification
- Functionsretinoic acid-responsive element binding / RNA polymerase II core promoter proximal region sequence-specific DNA binding / RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding / sequence-specific DNA binding / steroid hormone receptor activity / transcription coactivator activity / transcription factor activity, sequence-specific DNA binding / transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding / zinc ion bindingProcessesnegative regulation of neuron projection development / negative regulation of transcription from RNA polymerase II promoter / positive regulation of transcription from RNA polymerase II promoter / signal transduction / transcription initiation from RNA polymerase II promoterComponentsnucleoplasm / nucleus
- General Function
- Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG.
- Specific Function
- Retinoic acid-responsive element binding
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0049623|COUP transcription factor 1 (NR2F1) ATGGCAATGGTAGTTAGCAGCTGGCGAGATCCGCAGGACGACGTGGCCGGGGGCAACCCC GGCGGCCCCAACCCCGCAGCGCAGGCGGCCCGCGGCGGCGGCGGCGGCGCCGGCGAGCAG CAGCAGCAGGCGGGCTCGGGCGCGCCGCACACGCCGCAGACCCCGGGCCAGCCCGGAGCG CCCGCCACCCCCGGCACGGCGGGGGACAAGGGCCAGGGCCCGCCCGGTTCGGGCCAGAGC CAGCAGCACATCGAGTGCGTGGTGTGCGGGGACAAGTCGAGCGGCAAGCACTACGGCCAA TTCACCTGCGAGGGCTGCAAAAGTTTCTTCAAGAGGAGCGTCCGCAGGAACTTAACTTAC ACATGCCGTGCCAACAGGAACTGTCCCATCGACCAGCACCACCGCAACCAGTGCCAATAC TGCCGCCTCAAGAAGTGCCTCAAAGTGGGCATGAGGCGGGAAGCGGTTCAGCGAGGAAGA ATGCCTCCAACCCAGCCCAATCCAGGCCAGTACGCACTCACCAACGGGGACCCCCTCAAC GGCCACTGCTACCTGTCCGGCTACATCTCGCTGCTGCTGCGCGCCGAGCCCTACCCCACG TCGCGCTACGGCAGCCAGTGCATGCAGCCCAACAACATTATGGGCATCGAGAACATCTGC GAGCTGGCCGCGCGCCTGCTCTTCAGCGCCGTCGAGTGGGCCCGCAACATCCCCTTCTTC CCGGATCTGCAGATCACCGACCAGGTGTCCCTGCTACGCCTCACCTGGAGCGAGCTGTTC GTGCTCAACGCGGCCCAGTGCTCTATGCCGCTGCACGTGGCGCCGTTGCTGGCCGCCGCC GGCCTGCATGCCTCGCCCATGTCTGCCGACCGCGTCGTGGCCTTCATGGACCACATCCGC ATCTTCCAGGAGCAGGTGGAGAAGCTCAAGGCGCTACACGTCGACTCAGCCGAGTACAGC TGCCTCAAAGCCATCGTGCTGTTCACGTCAGACGCCTGTGGCCTGTCGGATGCGGCCCAC ATCGAGAGCCTGCAGGAGAAGTCGCAGTGCGCACTGGAGGAGTACGTGAGGAGCCAGTAC CCCAACCAGCCCAGCCGTTTTGGCAAACTGCTGCTGCGACTGCCCTCGCTGCGCACCGTG TCCTCCTCCGTCATCGAGCAGCTCTTCTTCGTCCGTTTGGTAGGTAAAACCCCCATCGAA ACTCTCATCCGCGATATGTTACTGTCTGGGAGCAGCTTCAACTGGCCTTACATGTCCATC CAGTGCTCCTAG
- Chromosome Location
- 5
- Locus
- 5q15
- External Identifiers
Resource Link UniProtKB ID P10589 UniProtKB Entry Name COT1_HUMAN HGNC ID HGNC:7975 - General References
- Wang LH, Tsai SY, Cook RG, Beattie WG, Tsai MJ, O'Malley BW: COUP transcription factor is a member of the steroid receptor superfamily. Nature. 1989 Jul 13;340(6229):163-6. [Article]
- Miyajima N, Kadowaki Y, Fukushige S, Shimizu S, Semba K, Yamanashi Y, Matsubara K, Toyoshima K, Yamamoto T: Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other. Nucleic Acids Res. 1988 Dec 9;16(23):11057-74. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A: Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily. Mol Cell Biol. 1999 May;19(5):3383-94. [Article]
- Zhang Y, Dufau ML: Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor. J Biol Chem. 2000 Jan 28;275(4):2763-70. [Article]
- Zhang Y, Dufau ML: EAR2 and EAR3/COUP-TFI regulate transcription of the rat LH receptor. Mol Endocrinol. 2001 Nov;15(11):1891-905. [Article]
- Bosch DG, Boonstra FN, Gonzaga-Jauregui C, Xu M, de Ligt J, Jhangiani S, Wiszniewski W, Muzny DM, Yntema HG, Pfundt R, Vissers LE, Spruijt L, Blokland EA, Chen CA, Lewis RA, Tsai SY, Gibbs RA, Tsai MJ, Lupski JR, Zoghbi HY, Cremers FP, de Vries BB, Schaaf CP: NR2F1 mutations cause optic atrophy with intellectual disability. Am J Hum Genet. 2014 Feb 6;94(2):303-9. doi: 10.1016/j.ajhg.2014.01.002. Epub 2014 Jan 23. [Article]