Cytochrome P450 2C12, female-specific
Details
- Name
- Cytochrome P450 2C12, female-specific
- Synonyms
- 1.14.14.1
- Cyp2c-12
- Cyp2c40
- CYPIIC12
- Cytochrome P450 15-beta
- Cytochrome P450-UT-1
- Cytochrome P450-UT-I
- Cytochrome P450I
- Gene Name
- Cyp2c12
- Organism
- Rat
- Amino acid sequence
>lcl|BSEQ0052509|Cytochrome P450 2C12, female-specific MDPFVVLVLSLSFLLLLYLWRPSPGRGKLPPGPTPLPIFGNFLQIDMKDIRQSISNFSKT YGPVFTLYFGSQPTVVLHGYEAVKEALIDYGEEFSGRGRMPVFEKATKGLGISFSRGNVW RATRHFTVNTLRSLGMGKRTIEIKVQEEAEWLVMELKKTKGSPCDPKFIIGCAPCNVICS IIFQNRFDYKDKDFLSLIENVNEYIKIVSTPAFQVFNAFPILLDYCPGNHKTHSKHFAAI KSYLLKKIKEHEESLDVSNPRDFIDYFLIQRCQENGNQQMNYTQEHLAILVTNLFIGGTE TSSLTLRFALLLLMKYPHITDKVQEEIGQVIGRHRSPCMLDRIHMPYTNAMIHEVQRYID LAPNGLLHEVTCDTKFRDYFIPKGTAVLTSLTSVLHARKEFPNPEMFDPGHFLDENGNFK KSDYFMPFSAGKRKCVGEGLASMELFLFLTTILQNFKLKSLSDPKDIDINSIRSEFSSIP PTFQLCFIPV
- Number of residues
- 490
- Molecular Weight
- 55918.365
- Theoretical pI
- Not Available
- GO Classification
- Functionsarachidonic acid epoxygenase activity / aromatase activity / heme binding / iron ion binding / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen / steroid hydroxylase activityProcessesepoxygenase P450 pathway / exogenous drug catabolic process / organic acid metabolic process / oxidation-reduction process / xenobiotic metabolic processComponentscytoplasm / endoplasmic reticulum membrane / intracellular membrane-bounded organelle
- General Function
- This P450 is active in 15-beta-hydroxylation of steroid sulfates.
- Specific Function
- Arachidonic acid epoxygenase activity
- Pfam Domain Function
- p450 (PF00067)
- Transmembrane Regions
- Not Available
- Cellular Location
- Endoplasmic reticulum membrane
- Gene sequence
>lcl|BSEQ0052510|Cytochrome P450 2C12, female-specific (Cyp2c12) ATGGATCCATTTGTGGTCTTGGTGCTCAGTCTGTCCTTTCTGCTTCTCCTGTATCTATGG AGACCAAGCCCTGGGAGAGGGAAGCTTCCTCCTGGCCCTACTCCTCTCCCAATTTTTGGA AATTTTCTTCAGATAGATATGAAGGACATCCGTCAATCAATATCCAATTTTTCTAAAACC TATGGCCCTGTGTTCACTTTGTATTTCGGCTCACAGCCTACTGTGGTATTGCATGGCTAT GAGGCAGTGAAAGAAGCCCTCATTGATTATGGGGAAGAGTTCTCTGGAAGGGGAAGAATG CCAGTTTTTGAAAAGGCTACTAAAGGACTGGGCATTAGTTTTAGCCGTGGAAATGTATGG AGAGCCACAAGACATTTCACAGTCAATACCCTGAGGAGTTTGGGCATGGGGAAACGGACC ATTGAGATCAAAGTGCAAGAGGAAGCAGAGTGGCTAGTGATGGAACTGAAGAAAACCAAA GGCTCACCCTGTGATCCCAAATTCATCATAGGATGTGCTCCCTGCAATGTCATCTGCTCC ATTATCTTCCAGAATCGTTTCGATTATAAAGATAAGGATTTTCTTAGCTTGATAGAAAAC GTGAATGAGTACATTAAAATTGTGAGCACTCCTGCATTTCAGGTTTTCAACGCATTCCCT ATTCTTCTGGATTATTGTCCAGGAAATCATAAGACACATTCAAAACATTTTGCTGCTATT AAGAGTTACCTTTTGAAGAAAATAAAAGAACATGAAGAATCGTTGGATGTTTCAAATCCT CGGGACTTCATTGATTACTTCCTAATTCAAAGATGTCAGGAAAATGGCAATCAGCAGATG AACTATACACAAGAACATCTGGCAATCCTGGTGACTAATTTGTTTATTGGTGGAACAGAG ACATCAAGCTTAACGCTGAGATTTGCACTTTTGCTCTTGATGAAGTACCCACACATCACA GATAAAGTCCAGGAAGAGATTGGCCAAGTGATTGGGAGACACCGCAGCCCCTGTATGTTG GACAGGATCCACATGCCCTACACAAATGCCATGATTCATGAGGTTCAGAGATATATTGAC CTTGCCCCAAATGGTTTGTTGCATGAAGTGACCTGTGACACTAAATTCAGAGACTACTTC ATACCCAAGGGAACAGCAGTACTAACATCACTTACATCAGTGCTGCATGCACGTAAGGAA TTCCCCAACCCAGAGATGTTTGACCCAGGTCACTTTCTAGATGAGAATGGAAACTTTAAG AAAAGTGACTACTTCATGCCTTTCTCAGCAGGAAAACGGAAATGTGTGGGAGAGGGCCTT GCCAGTATGGAGCTGTTTTTGTTCCTGACCACCATTTTACAGAATTTCAAACTGAAATCT CTGTCTGATCCAAAGGACATCGATATAAACTCAATACGTTCTGAGTTTTCATCAATTCCT CCAACTTTCCAGCTGTGCTTCATTCCTGTCTAA
- Chromosome Location
- 1
- Locus
- 1q53
- External Identifiers
Resource Link UniProtKB ID P11510 UniProtKB Entry Name CP2CC_RAT - General References
- Zaphiropoulos PG, Mode A, Strom A, Moller C, Fernandez C, Gustafsson JA: cDNA cloning, sequence, and regulation of a major female-specific and growth hormone-inducible rat liver cytochrome P-450 active in 15 beta-hydroxylation of steroid sulfates. Proc Natl Acad Sci U S A. 1988 Jun;85(12):4214-7. doi: 10.1073/pnas.85.12.4214. [Article]
- Zaphiropoulos PG, Mode A, Strom A, Husman B, Andersson G, Gustafsson JA: Sequence and regulation of two growth-hormone-controlled, sex-specific isozymes of cytochrome P-450 in rat liver, P-450(15)beta and P-450(16)alpha. Acta Med Scand Suppl. 1988;723:161-7. [Article]