Hemagglutinin-neuraminidase

Details

Name
Hemagglutinin-neuraminidase
Synonyms
  • 3.2.1.18
Gene Name
HN
Organism
HPIV-3
Amino acid sequence
>lcl|BSEQ0019170|Hemagglutinin-neuraminidase
MEYWKHTNHGKDAGNELETSMATHGNKLTNKIIYILWTIILVLLSIVFIIVLINSIKSEK
AHESLLRDINNEFMEITGKIQMASDNTNDLIQSGVNTRLLTIQSHVQNYIPISLTQQMSD
LRKFISEITIRNDNQEVLPQRITHDVGIKPLNPDDFWRCTSGLPSLMKTPKIRLMPGPGL
LAMPTTDDGCIRTPSLVINDLIYAYTSNLITRGCQDIGKSYQVLQIGIITVNSDLVPDLN
PRISHTFNINDNRKSCSLALLNTDVYQLCSTPKVDERSDYASSGIEDIVLDIVNYDGSIS
TTRFKNNNISFDQPYAALYPSVGPGIYYKGKIIFLGYGGLEHPINENVICNTTGCPGKTQ
RDCNQASHSPWFSDRRMVNSIIVVDKGLNSTPKLKVWTISMRQNYWGSEGRLLLLGNKIY
IYTRSTSWHSKLQLGIIDITDYSDIRIKWTWHNVLSRPGNNECPWGHSCPDGCITGVYTD
AYPLNPTGSIVSSVILDSQKSRVNPVITYSTATERVNELAIRNRTLSAGYTTTSCITHYN
KGYCFHIVEINHKSLNTFQPMLFKTEIPKSCS
Number of residues
572
Molecular Weight
64329.845
Theoretical pI
7.96
GO Classification
Functions
exo-alpha-(2->3)-sialidase activity / exo-alpha-(2->6)-sialidase activity / exo-alpha-(2->8)-sialidase activity
Processes
viral entry into host cell / virion attachment to host cell
Components
host cell plasma membrane / integral component of membrane / viral envelope / virion membrane
General Function
Exo-alpha-(2->8)-sialidase activity
Specific Function
Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity).Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.
Pfam Domain Function
Transmembrane Regions
32-52
Cellular Location
Virion membrane
Gene sequence
>lcl|BSEQ0003418|1719 bp
ATGGAATACTGGAAGCATACCAATCACGGAAAGGATGCTGGTAATGAGCTGGAGACGTCC
ATGGCTACTCATGGCAACAAGCTCACTAATAAGATAATATACATATTATGGACAATAATC
CTGGTGTTATTATCAATAGTCTTCATCATAGTGCTAATCAATTCCATCAAAAGTGAAAAG
GCCCACGAATCATTGCTGCGAGACATAAACAATGAGTTTATGGAAATTACAGGAAAGATC
CAAATGGCATCGGATAATACCAATGATCTAATACAGTCAGGAGTGAATACAAGGCTTCTT
ACAATTCAGAGTCATGTCCAGAATTACATACCAATATCATTGACACAACAGATGTCAGAT
CTTAGGAAATTCATTAGTGAAATTACAATTAGAAATGATAATCAAGAAGTGCTGCCGCAA
AGAATAACACATGATGTAGGTATAAAACCTTTAAATCCAGATGATTTTTGGAGATGCACG
TCTGGTCTTCCATCTTTAATGAAAACTCCAAAAATAAGGTTAATGCCAGGGCCGGGGTTA
TTAGCTATGCCAACGACTGATGATGGCTGTATTAGAACTCCGTCTTTAGTTATAAATGAT
CTGATTTATGCTTATACCTCAAATCTAATTACTCGAGGTTGTCAGGATATAGGAAAATCA
TATCAAGTCTTACAGATAGGGATAATAACTGTAAACTCAGACTTGGTACCTGACTTAAAT
CCTAGGATCTCTCATACTTTCAACATAAATGACAATAGGAAGTCATGCTCTCTAGCACTC
CTAAATACAGATGTATATCAACTGTGTTCAACTCCCAAAGTTGATGAAAGATCAGATTAT
GCATCATCAGGCATAGAAGATATTGTACTTGATATTGTCAATTATGATGGCTCAATCTCA
ACAACAAGATTTAAGAATAATAACATAAGCTTTGATCAACCATATGCTGCGCTATACCCA
TCTGTTGGACCAGGGATATACTACAAAGGCAAAATAATATTTCTCGGATATGGAGGTCTT
GAACATCCAATAAATGAGAATGTAATCTGCAATACAACTGGGTGTCCCGGGAAAACACAG
AGAGACTGTAATCAAGCGTCTCATAGTCCATGGTTTTCAGATAGGAGGATGGTCAACTCC
ATCATTGTTGTTGACAAAGGCTTAAACTCAACTCCAAAATTGAAGGTATGGACGATATCT
ATGCGACAAAATTACTGGGGGTCAGAAGGAAGGTTACTTCTACTAGGTAACAAGATCTAT
ATATATACAAGATCTACAAGTTGGCATAGCAAGTTACAATTAGGAATAATTGATATTACT
GATTACAGTGATATAAGGATAAAATGGACATGGCATAATGTGCTATCAAGACCAGGAAAC
AATGAATGTCCATGGGGACATTCATGTCCAGATGGATGTATAACAGGAGTATATACTGAT
GCATATCCACTCAATCCCACAGGGAGCATTGTGTCATCTGTCATATTAGACTCACAAAAA
TCGAGAGTGAACCCAGTCATAACTTACTCAACAGCAACCGAAAGAGTAAACGAGCTGGCC
ATCCGAAACAGAACACTCTCAGCTGGATATACAACAACAAGCTGCATTACACACTATAAC
AAAGGATATTGTTTTCATATAGTAGAAATAAATCATAAAAGCTTAAACACATTTCAACCC
ATGTTGTTCAAAACAGAGATTCCAAAAAGCTGCAGTTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP12564
UniProtKB Entry NameHN_PI3HV
GenBank Protein ID332715
GenBank Gene IDM18764
General References
  1. van Wyke Coelingh KL, Winter CC, Murphy BR: Nucleotide and deduced amino acid sequence of hemagglutinin-neuraminidase genes of human type 3 parainfluenza viruses isolated from 1957 to 1983. Virology. 1988 Jan;162(1):137-43. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB039912-deoxy-2,3-dehydro-N-acetylneuraminic acidexperimentalunknownDetails
DB04265N-acetyl-beta-neuraminic acidexperimentalunknownDetails