Cholesterol oxidase
Details
- Name
- Cholesterol oxidase
- Synonyms
- 1.1.3.6
- CHOD
- Cholesterol isomerase
- Gene Name
- choA
- Organism
- Streptomyces sp. (strain SA-COO)
- Amino acid sequence
>lcl|BSEQ0019134|Cholesterol oxidase MTAQQHLSRRRMLGMAAFGAAALAGGTTIAAPRAAAAAKSAADNGGYVPAVVIGTGYGAA VSALRLGEAGVQTLMLEMGQLWNQPGPDGNIFCGMLNPDKRSSWFKNRTEAPLGSFLWLD VVNRNIDPYAGVLDRVNYDQMSVYVGRGVGGGSLVNGGMAVEPKRSYFEEILPRVDSSEM YDRYFPRANSMLRVNHIDTKWFEDTEWYKFARVSREQAGKAGLGTVFVPNVYDFGYMQRE AAGEVPKSALATEVIYGNNHGKQSLDKTYLAAALGTGKVTIQTLHQVKTIRQTKDGGYAL TVEQKDTDGKLLATKEISCRYLFLGAGSLGSTELLVRARDTGTLPNLNSEVGAGWGPNGN IMTARANHMWNPTGAHQSSIPALGIDAWDNSDSSVFAEIAPMPAGLETWVSLYLAITKNP QRGTFVYDAATDRAKLNWTRDQNAPAVNAAKALFDRINKANGTIYRYDLFGTQLKAFADD FCYHPLGGCVLGKATDDYGRVAGYKNLYVTDGSLIPGSVGVNPFVTITALAERNVERIIK QDVTAS
- Number of residues
- 546
- Molecular Weight
- 58993.275
- Theoretical pI
- 8.49
- GO Classification
- Functionscholesterol oxidase activity / flavin adenine dinucleotide binding / steroid delta-isomerase activityProcessescholesterol metabolic processComponentsextracellular region
- General Function
- Steroid delta-isomerase activity
- Specific Function
- Bifunctional enzyme that catalyzes the oxidation of the 3-beta-hydroxy group of cholesterol and the isomerization of the double bond of the resulting product.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0003077|1641 bp GTGACTGCACAACAGCACCTGTCCCGCCGCCGCATGCTCGGCATGGCCGCCTTCGGCGCC GCCGCCCTCGCCGGGGGCACCACCATCGCCGCCCCCCGTGCGGCCGCCGCCGCCAAGTCC GCGGCGGACAACGGCGGTTACGTCCCCGCCGTCGTCATCGGCACCGGCTACGGCGCGGCC GTCTCCGCGCTGCGCCTCGGCGAGGCGGGTGTGCAGACCCTGATGCTGGAGATGGGCCAG CTGTGGAACCAGCCCGGCCCCGACGGCAACATCTTCTGCGGCATGCTCAACCCGGACAAG CGGTCCAGCTGGTTCAAGAACCGCACCGAGGCCCCGCTCGGCAGCTTCCTCTGGCTCGAC GTCGTCAACCGGAACATCGACCCCTACGCGGGTGTCCTGGACCGTGTGAACTACGACCAG ATGTCGGTCTACGTGGGCCGCGGCGTCGGCGGCGGCTCGCTCGTCAACGGCGGCATGGCC GTGGAGCCCAAGCGCTCGTACTTCGAGGAGATCCTCCCGCGGGTCGACTCCTCCGAGATG TACGACCGCTACTTCCCCCGCGCCAACTCCATGCTCCGCGTCAACCACATCGACACCAAG TGGTTCGAGGACACCGAGTGGTACAAGTTCGCCCGCGTCTCGCGCGAGCAGGCGGGCAAG GCCGGTCTCGGCACCGTCTTCGTCCCCAACGTCTACGACTTCGGCTACATGCAGCGCGAG GCCGCGGGCGAGGTGCCCAAGTCCGCCCTGGCGACCGAGGTCATCTACGGCAACAACCAC GGCAAGCAGAGCCTGGACAAGACCTACCTGGCCGCCGCACTCGGCACCGGCAAGGTCACC ATCCAGACCCTGCACCAGGTCAAGACGATCCGTCAGACGAAGGACGGCGGCTACGCGCTG ACCGTCGAGCAGAAGGACACCGACGGCAAGCTCCTGGCCACCAAGGAGATCTCCTGCCGC TACCTGTTCCTCGGCGCGGGCAGCCTCGGCTCCACCGAACTGCTGGTGCGCGCCCGCGAC ACCGGCACCCTGCCGAACCTCAACTCCGAGGTGGGCGCGGGCTGGGGCCCCAACGGCAAC ATCATGACCGCCCGGGCCAACCACATGTGGAACCCCACCGGCGCCCACCAGTCCTCCATC CCCGCCCTCGGCATCGACGCGTGGGACAACAGCGACTCCTCGGTCTTCGCGGAGATCGCC CCCATGCCGGCCGGCCTGGAGACGTGGGTCAGCCTCTACCTCGCGATCACCAAGAACCCC CAGCGCGGCACCTTCGTGTACGACGCCGCGACGGACCGCGCGAAGCTCAACTGGACCCGT GACCAGAACGCCCCCGCGGTCAACGCAGCCAAGGCGCTGTTCGACCGGATCAACAAGGCG AACGGCACGATCTACCGGTACGACCTCTTCGGCACCCAGCTGAAGGCCTTCGCCGACGAC TTCTGCTACCACCCGCTCGGCGGCTGCGTCCTGGGCAAGGCGACGGACGACTACGGCCGC GTCGCCGGTTACAAGAACCTCTACGTGACCGACGGTTCGCTGATCCCGGGTTCCGTCGGC GTCAACCCGTTCGTGACCATCACGGCGCTGGCCGAGCGGAACGTCGAGCGCATCATCAAG CAGGACGTCACGGCGTCGTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P12676 UniProtKB Entry Name CHOD_STRS0 GenBank Protein ID 153212 GenBank Gene ID M31939 - General References
- Ishizaki T, Hirayama N, Shinkawa H, Nimi O, Murooka Y: Nucleotide sequence of the gene for cholesterol oxidase from a Streptomyces sp. J Bacteriol. 1989 Jan;171(1):596-601. [Article]
- Yue QK, Kass IJ, Sampson NS, Vrielink A: Crystal structure determination of cholesterol oxidase from Streptomyces and structural characterization of key active site mutants. Biochemistry. 1999 Apr 6;38(14):4277-86. [Article]