Methionine gamma-lyase

Details

Name
Methionine gamma-lyase
Synonyms
  • 4.4.1.11
  • L-methioninase
Gene Name
mdeA
Organism
Pseudomonas putida
Amino acid sequence
>lcl|BSEQ0017023|Methionine gamma-lyase
MHGSNKLPGFATRAIHHGYDPQDHGGALVPPVYQTATFTFPTVEYGAACFAGEQAGHFYS
RISNPTLNLLEARMASLEGGEAGLALASGMGAITSTLWTLLRPGDEVLLGNTLYGCTFAF
LHHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESPANPNMHMADIAGVAKIARKHG
ATVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGIVVGSQALVDRIRLQGLK
DMTGAVLSPHDAALLMRGIKTLNLRMDRHCANAQVLAEFLARQPQVELIHYPGLASFPQY
TLARQQMSQPGGMIAFELKGGIGAGRRFMNALQLFSRAVSLGDAESLAQHPASMTHSSYT
PEERAHYGISEGLVRLSVGLEDIDDLLADVQQALKASA
Number of residues
398
Molecular Weight
42626.335
Theoretical pI
6.7
GO Classification
Functions
methionine gamma-lyase activity / pyridoxal phosphate binding
General Function
Pyridoxal phosphate binding
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0006258|1197 bp
ATGCACGGCTCCAACAAGCTCCCAGGATTTGCCACCCGCGCCATTCACCATGGCTACGAC
CCCCAGGACCACGGCGGCGCACTGGTGCCACCGGTCTACCAGACCGCGACGTTCACCTTC
CCCACCGTGGAATACGGCGCTGCGTGCTTTGCCGGCGAGCAGGCCGGGCATTTCTACAGC
CGCATCTCCAACCCCACCCTCAACCTGCTGGAAGCACGCATGGCCTCGCTGGAAGGCGGC
GAGGCCGGGCTGGCGCTGGCCTCGGGCATGGGGGCGATCACGTCCACGCTATGGACACTG
CTGCGCCCCGGTGACGAGGTGCTGCTGGGCAACACCCTGTACGGCTGCACCTTTGCCTTC
CTGCACCACGGCATCGGCGAGTTCGGGGTCAAGCTGCGCCATGTGGACATGGCCGACCTG
CAGGCACTGGAGGCGGCCATGACGCCGGCCACCCGGGTGATCTATTTCGAGTCGCCGGCC
AACCCCAACATGCACATGGCCGATATCGCCGGCGTGGCGAAGATTGCACGCAAGCACGGC
GCGACCGTGGTGGTCGACAACACCTACTGCACGCCGTACCTGCAACGGCCACTGGAGCTG
GGCGCCGACCTGGTGGTGCATTCGGCCACCAAGTACCTGAGCGGCCATGGCGACATCACT
GCTGGCATTGTGGTGGGCAGCCAGGCACTGGTGGACCGTATACGTCTGCAGGGCCTCAAG
GACATGACCGGTGCGGTGCTCTCGCCCCATGACGCCGCACTGTTGATGCGCGGCATCAAG
ACCCTCAACCTGCGCATGGACCGCCACTGCGCCAACGCTCAGGTGCTGGCCGAGTTCCTC
GCCCGGCAGCCGCAGGTGGAGCTGATCCATTACCCGGGCCTGGCGAGCTTCCCGCAGTAC
ACCCTGGCCCGCCAGCAGATGAGCCAGCCGGGCGGCATGATCGCCTTCGAACTCAAGGGC
GGCATCGGTGCCGGGCGGCGGTTCATGAACGCCCTGCAACTGTTCAGCCGCGCGGTGAGC
CTGGGCGATGCCGAGTCGCTGGCGCAGCACCCGGCAAGCATGACTCATTCCAGCTATACC
CCAGAGGAGCGTGCGCATTACGGCATCTCCGAGGGGCTGGTGCGGTTGTCGGTGGGGCTG
GAAGACATCGACGACCTGCTGGCCGATGTGCAACAGGCACTCAAGGCGAGTGCCTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP13254
UniProtKB Entry NameMEGL_PSEPU
GenBank Gene IDD88554
General References
  1. Inoue H, Inagaki K, Sugimoto M, Esaki N, Soda K, Tanaka H: Structural analysis of the L-methionine gamma-lyase gene from Pseudomonas putida. J Biochem. 1995 May;117(5):1120-5. [Article]
  2. Inoue H, Inagaki K, Eriguchi SI, Tamura T, Esaki N, Soda K, Tanaka H: Molecular characterization of the mde operon involved in L-methionine catabolism of Pseudomonas putida. J Bacteriol. 1997 Jun;179(12):3956-62. [Article]
  3. Nakayama T, Esaki N, Tanaka H, Soda K: Specific labeling of the essential cysteine residue of L-methionine gamma-lyase with a cofactor analogue, N-(bromoacetyl)pyridoxamine phosphate. Biochemistry. 1988 Mar 8;27(5):1587-91. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04083N(6)-(pyridoxal phosphate)-L-lysineexperimentalunknownDetails