Intron-associated endonuclease 1
Details
- Name
- Intron-associated endonuclease 1
- Synonyms
- 3.1.-.-
- I-TevI
- IRF protein
- Gene Name
- ITEVIR
- Organism
- Enterobacteria phage T4
- Amino acid sequence
>lcl|BSEQ0012075|Intron-associated endonuclease 1 MKSGIYQIKNTLNNKVYVGSAKDFEKRWKRHFKDLEKGCHSSIKLQRSFNKHGNVFECSI LEEIPYEKDLIIERENFWIKELNSKINGYNIADATFGDTCSTHPLKEEIIKKRSETVKAK MLKLGPDGRKALYSKPGSKNGRWNPETHKFCKCGVRIQTSAYTCSKCRNRSGENNSFFNH KHSDITKSKISEKMKGKKPSNIKKISCDGVIFDCAADAARHFKISSGLVTYRVKSDKWNW FYINA
- Number of residues
- 245
- Molecular Weight
- 28232.2
- Theoretical pI
- 10.26
- GO Classification
- FunctionsDNA binding / endonuclease activityProcessesintron homing
- General Function
- Endonuclease activity
- Specific Function
- This endonuclease is specific to the thymidylate synthase (td) gene splice junction and is involved in intron homing.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0012076|Intron-associated endonuclease 1 (ITEVIR) ATGAAAAGCGGAATTTATCAGATTAAAAATACTTTAAACAATAAAGTATATGTAGGAAGT GCTAAAGATTTTGAAAAGAGATGGAAGAGGCATTTTAAAGATTTAGAAAAAGGATGCCAT TCTTCTATAAAACTTCAGAGGTCTTTTAACAAACATGGTAATGTGTTTGAATGTTCTATT TTGGAAGAAATTCCATATGAGAAAGATTTGATTATTGAACGAGAAAATTTTTGGATTAAA GAGCTTAATTCTAAAATTAATGGATACAATATTGCTGATGCAACGTTTGGTGATACATGT TCTACGCATCCATTAAAAGAAGAAATTATTAAGAAACGTTCTGAAACTGTTAAAGCTAAG ATGCTTAAACTTGGACCTGATGGTCGGAAAGCTCTTTACAGTAAACCCGGAAGTAAAAAC GGGCGTTGGAATCCAGAAACCCATAAGTTTTGTAAGTGCGGTGTTCGCATACAAACTTCT GCTTATACTTGTAGTAAATGCAGAAATCGTTCAGGTGAAAATAATTCATTCTTTAATCAT AAGCATTCAGACATAACTAAATCTAAAATATCAGAAAAGATGAAAGGTAAAAAGCCTAGT AATATTAAAAAGATTTCATGTGATGGGGTTATTTTTGATTGTGCAGCAGATGCAGCTAGA CATTTTAAAATTTCGTCTGGATTAGTTACTTATCGTGTAAAATCTGATAAATGGAATTGG TTCTACATAAATGCCTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P13299 UniProtKB Entry Name TEV1_BPT4 GenBank Gene ID M12742 - General References
- Chu FK, Maley GF, West DK, Belfort M, Maley F: Characterization of the intron in the phage T4 thymidylate synthase gene and evidence for its self-excision from the primary transcript. Cell. 1986 Apr 25;45(2):157-66. [Article]
- Miller ES, Kutter E, Mosig G, Arisaka F, Kunisawa T, Ruger W: Bacteriophage T4 genome. Microbiol Mol Biol Rev. 2003 Mar;67(1):86-156, table of contents. [Article]
- West DK, Changchien LM, Maley GF, Maley F: Evidence that the intron open reading frame of the phage T4 td gene encodes a specific endonuclease. J Biol Chem. 1989 Jun 25;264(18):10343-6. [Article]