Insulin receptor-related protein
Details
- Name
- Insulin receptor-related protein
- Synonyms
- 2.7.10.1
- IR-related receptor
- IRR
- Gene Name
- INSRR
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0051780|Insulin receptor-related protein MAVPSLWPWGACLPVIFLSLGFGLDTVEVCPSLDIRSEVAELRQLENCSVVEGHLQILLM FTATGEDFRGLSFPRLTQVTDYLLLFRVYGLESLRDLFPNLAVIRGTRLFLGYALVIFEM PHLRDVALPALGAVLRGAVRVEKNQELCHLSTIDWGLLQPAPGANHIVGNKLGEECADVC PGVLGAAGEPCAKTTFSGHTDYRCWTSSHCQRVCPCPHGMACTARGECCHTECLGGCSQP EDPRACVACRHLYFQGACLWACPPGTYQYESWRCVTAERCASLHSVPGRASTFGIHQGSC LAQCPSGFTRNSSSIFCHKCEGLCPKECKVGTKTIDSIQAAQDLVGCTHVEGSLILNLRQ GYNLEPQLQHSLGLVETITGFLKIKHSFALVSLGFFKNLKLIRGDAMVDGNYTLYVLDNQ NLQQLGSWVAAGLTIPVGKIYFAFNPRLCLEHIYRLEEVTGTRGRQNKAEINPRTNGDRA ACQTRTLRFVSNVTEADRILLRWERYEPLEARDLLSFIVYYKESPFQNATEHVGPDACGT QSWNLLDVELPLSRTQEPGVTLASLKPWTQYAVFVRAITLTTEEDSPHQGAQSPIVYLRT LPAAPTVPQDVISTSNSSSHLLVRWKPPTQRNGNLTYYLVLWQRLAEDGDLYLNDYCHRG LRLPTSNNDPRFDGEDGDPEAEMESDCCPCQHPPPGQVLPPLEAQEASFQKKFENFLHNA ITIPISPWKVTSINKSPQRDSGRHRRAAGPLRLGGNSSDFEIQEDKVPRERAVLSGLRHF TEYRIDIHACNHAAHTVGCSAATFVFARTMPHREADGIPGKVAWEASSKNSVLLRWLEPP DPNGLILKYEIKYRRLGEEATVLCVSRLRYAKFGGVHLALLPPGNYSARVRATSLAGNGS WTDSVAFYILGPEEEDAGGLHVLLTATPVGLTLLIVLAALGFFYGKKRNRTLYASVNPEY FSASDMYVPDEWEVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELAS PRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAEN NPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDV YETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQ VLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQEELRPSFRLLSFY YSPECRGARGSLPTTDAEPDSSPTPRDCSPQNGGPGH
- Number of residues
- 1297
- Molecular Weight
- 143718.73
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / insulin receptor substrate binding / phosphatidylinositol 3-kinase binding / transmembrane receptor protein tyrosine kinase activityProcessesactin cytoskeleton reorganization / cellular response to alkaline pH / male sex determination / protein autophosphorylation / transmembrane receptor protein tyrosine kinase signaling pathwayComponentsintegral component of plasma membrane / receptor complex
- General Function
- Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.
- Specific Function
- Atp binding
- Pfam Domain Function
- Transmembrane Regions
- 922-943
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0051781|Insulin receptor-related protein (INSRR) ATGGCAGTGCCTAGTCTGTGGCCCTGGGGAGCATGCCTGCCTGTGATCTTCCTCTCCTTG GGATTTGGCCTGGATACAGTAGAGGTGTGCCCCAGCCTGGATATTCGCTCAGAGGTGGCA GAGCTTCGTCAGCTGGAGAACTGCAGCGTGGTGGAGGGCCACCTGCAGATCCTGCTCATG TTCACAGCCACCGGGGAGGACTTCCGCGGCCTCAGCTTCCCTCGCCTCACCCAGGTCACC GACTACCTGCTGCTCTTCCGTGTCTACGGACTGGAGAGCCTGCGCGACCTCTTCCCCAAC CTAGCAGTCATCCGCGGGACGCGCCTCTTCCTGGGCTATGCACTGGTCATCTTTGAGATG CCACATCTGCGTGACGTGGCACTGCCTGCACTTGGGGCCGTGCTGCGTGGGGCTGTGCGT GTGGAGAAGAACCAGGAGCTCTGCCACCTCTCCACCATTGACTGGGGACTGCTGCAGCCA GCACCTGGCGCCAACCACATCGTGGGCAACAAGCTGGGCGAGGAGTGTGCTGACGTGTGC CCTGGTGTGCTGGGTGCTGCTGGTGAGCCCTGTGCCAAGACCACCTTCAGCGGGCACACT GACTACAGATGCTGGACCTCCAGCCACTGCCAGAGAGTGTGCCCCTGCCCCCATGGGATG GCTTGCACAGCGAGGGGCGAGTGCTGCCACACCGAATGCCTGGGGGGCTGCAGCCAGCCA GAAGACCCTCGTGCCTGTGTAGCTTGCCGCCACCTCTACTTCCAGGGTGCCTGCCTGTGG GCCTGCCCGCCAGGCACCTACCAGTATGAGTCCTGGCGCTGTGTCACAGCTGAGCGCTGT GCCAGCCTGCACTCTGTGCCCGGCCGTGCCTCCACCTTCGGCATACACCAGGGCAGTTGC CTGGCCCAGTGCCCTTCTGGCTTCACCCGTAATAGCAGCAGCATATTCTGCCACAAGTGC GAGGGGCTGTGCCCTAAAGAGTGCAAGGTAGGCACCAAGACCATCGACTCCATCCAGGCG GCACAGGATCTTGTGGGCTGCACGCATGTGGAGGGAAGCCTCATCCTCAACCTTCGCCAG GGCTACAACCTGGAGCCACAGCTGCAGCACAGCCTGGGGCTGGTAGAAACCATTACTGGC TTCCTCAAAATCAAGCACTCCTTTGCCCTCGTGTCCCTGGGCTTTTTCAAGAACCTCAAA CTAATCCGGGGAGACGCCATGGTGGATGGGAACTACACTCTCTACGTGCTGGACAACCAG AACCTACAACAGCTAGGGTCCTGGGTGGCCGCGGGGCTCACCATTCCCGTGGGCAAGATC TACTTCGCCTTCAACCCGCGCCTCTGCTTGGAACACATCTACCGACTGGAGGAGGTGACA GGCACGCGAGGTCGGCAGAACAAGGCTGAGATCAACCCCCGCACCAACGGAGACCGCGCC GCCTGCCAGACTCGCACCCTGCGCTTCGTGTCCAACGTGACGGAGGCAGACCGCATCCTG CTACGCTGGGAGCGCTATGAGCCACTGGAGGCCCGCGACCTGCTCAGCTTCATCGTGTAC TACAAGGAGTCCCCATTCCAGAACGCCACAGAGCACGTGGGTCCAGATGCTTGTGGAACC CAGAGCTGGAACCTGCTGGATGTGGAGCTGCCCCTAAGCCGCACCCAGGAGCCAGGGGTG ACCCTAGCCTCCCTCAAGCCTTGGACACAGTACGCAGTGTTTGTGCGGGCCATCACGCTA ACCACTGAGGAGGACAGCCCTCATCAAGGAGCCCAGAGTCCCATCGTCTACCTCCGAACG CTGCCTGCAGCTCCCACGGTGCCCCAAGACGTCATCTCCACGTCCAACTCCTCCTCCCAC CTCCTGGTGCGCTGGAAGCCACCGACCCAGCGCAATGGGAACCTCACCTACTACCTGGTG CTGTGGCAGCGGCTGGCAGAGGACGGCGACCTCTACCTCAATGACTACTGCCACCGCGGC TTGCGGCTGCCCACCAGCAACAACGATCCGCGCTTCGACGGCGAAGACGGGGATCCTGAG GCCGAGATGGAGTCCGACTGCTGCCCTTGCCAGCACCCACCTCCTGGTCAGGTTCTGCCC CCGCTGGAGGCGCAAGAGGCCTCGTTCCAGAAGAAGTTTGAAAACTTTCTACACAACGCG ATCACCATCCCCATATCCCCTTGGAAGGTGACGTCCATCAACAAGAGCCCCCAAAGGGAC TCAGGGCGGCACCGCCGGGCAGCTGGGCCCCTCCGGCTGGGGGGCAACAGCTCGGATTTC GAGATCCAGGAGGACAAGGTGCCCCGTGAGCGAGCGGTGCTGAGCGGCCTGCGCCACTTC ACGGAATACCGGATCGACATCCATGCCTGCAACCACGCGGCGCACACCGTGGGCTGCAGC GCCGCCACCTTCGTCTTTGCGCGCACCATGCCCCACAGAGAGGCTGATGGTATTCCAGGA AAGGTGGCCTGGGAGGCCTCCAGCAAGAACAGTGTCCTTCTGCGCTGGCTCGAGCCACCA GACCCCAACGGACTCATCCTCAAGTACGAAATCAAGTACCGCCGCTTGGGAGAGGAGGCC ACAGTGCTGTGTGTGTCCCGTCTTCGATATGCGAAGTTTGGGGGAGTCCACCTGGCCCTG CTGCCCCCTGGAAACTACTCTGCCAGGGTTAGGGCAACCTCACTGGCTGGCAATGGCTCT TGGACAGACAGTGTTGCCTTCTACATCCTTGGCCCAGAGGAGGAGGATGCTGGGGGGCTG CATGTCCTCCTCACTGCCACCCCTGTGGGGCTCACGCTGCTCATCGTTCTTGCTGCCCTT GGTTTCTTCTACGGCAAGAAGAGAAACAGAACCCTGTATGCTTCTGTGAATCCAGAGTAC TTCAGCGCCTCTGATATGTATGTCCCTGATGAATGGGAGGTGCCTCGGGAGCAGATCTCG ATAATCCGGGAACTGGGCCAGGGCTCTTTTGGGATGGTATATGAGGGGCTGGCACGAGGA CTTGAGGCTGGAGAGGAGTCCACACCCGTGGCCCTGAAGACGGTGAATGAGCTGGCCAGC CCACGGGAATGCATTGAGTTCCTCAAGGAAGCTTCTGTCATGAAAGCCTTCAAGTGTCAC CATGTGGTGCGTCTCCTGGGTGTGGTATCTCAGGGCCAGCCAACTCTGGTCATCATGGAG TTAATGACCCGTGGGGACCTCAAGAGCCATCTTCGATCTTTGCGGCCTGAGGCAGAGAAC AACCCTGGGCTCCCACAGCCAGCATTGGGGGAAATGATCCAAATGGCTGGTGAGATTGCA GACGGCATGGCCTACCTTGCTGCCAACAAGTTTGTGCACCGAGATCTAGCAGCCCGCAAC TGCATGGTGTCCCAGGACTTCACCGTCAAGATCGGGGACTTCGGGATGACTCGGGACGTG TATGAGACAGACTATTACCGCAAGGGTGGGAAGGGGCTGCTGCCCGTGCGCTGGATGGCC CCCGAGTCCCTCAAAGATGGGATCTTCACCACCCACTCGGATGTCTGGTCCTTTGGCGTG GTACTCTGGGAGATTGTGACCCTGGCAGAACAACCCTACCAGGGCCTGTCCAATGAGCAG GTGCTGAAGTTCGTCATGGATGGCGGGGTCCTGGAGGAGCTGGAGGGCTGTCCCCTTCAG CTGCAGGAGCTGATGAGCCGCTGCTGGCAGCCGAACCCACGCCTGCGCCCATCTTTCACA CACATTCTGGACAGCATACAGGAGGAGCTGCGGCCCTCCTTCCGCCTCCTCTCCTTCTAC TACAGCCCGGAATGCCGGGGGGCCCGGGGCTCCCTGCCTACCACCGATGCAGAGCCTGAC TCCTCACCCACTCCAAGAGACTGCAGCCCTCAAAATGGGGGTCCAGGGCACTGA
- Chromosome Location
- 1
- Locus
- 1q23.1
- External Identifiers
Resource Link UniProtKB ID P14616 UniProtKB Entry Name INSRR_HUMAN HGNC ID HGNC:6093 - General References
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