Immunoglobulin lambda-like polypeptide 1


Immunoglobulin lambda-like polypeptide 1
  • CD179 antigen-like family member B
  • Ig lambda-5
  • IGL1
  • Immunoglobulin omega polypeptide
  • Immunoglobulin-related protein 14.1
Gene Name
Amino acid sequence
>lcl|BSEQ0049830|Immunoglobulin lambda-like polypeptide 1
Number of residues
Molecular Weight
Theoretical pI
Not Available
GO Classification
antigen binding / immunoglobulin receptor binding
B cell receptor signaling pathway / complement activation, classical pathway / defense response to bacterium / immune response / innate immune response / leukocyte migration / phagocytosis, engulfment / phagocytosis, recognition / positive regulation of B cell activation
blood microparticle / external side of plasma membrane / extracellular exosome / extracellular region / immunoglobulin complex, circulating / membrane
General Function
Critical for B-cell development.
Specific Function
Antigen binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Gene sequence
>lcl|BSEQ0049831|Immunoglobulin lambda-like polypeptide 1 (IGLL1)
Chromosome Location
External Identifiers
UniProtKB IDP15814
UniProtKB Entry NameIGLL1_HUMAN
General References
  1. Hollis GF, Evans RJ, Stafford-Hollis JM, Korsmeyer SJ, McKearn JP: Immunoglobulin lambda light-chain-related genes 14.1 and 16.1 are expressed in pre-B cells and may encode the human immunoglobulin omega light-chain protein. Proc Natl Acad Sci U S A. 1989 Jul;86(14):5552-6. [Article]
  2. Evans RJ, Hollis GF: Genomic structure of the human Ig lambda 1 gene suggests that it may be expressed as an Ig lambda 14.1-like protein or as a canonical B cell Ig lambda light chain: implications for Ig lambda gene evolution. J Exp Med. 1991 Feb 1;173(2):305-11. [Article]
  3. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al.: The DNA sequence of human chromosome 22. Nature. 1999 Dec 2;402(6761):489-95. [Article]
  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  5. Schiff C, Bensmana M, Guglielmi P, Milili M, Lefranc MP, Fougereau M: The immunoglobulin lambda-like gene cluster (14.1, 16.1 and F lambda 1) contains gene(s) selectively expressed in pre-B cells and is the human counterpart of the mouse lambda 5 gene. Int Immunol. 1990;2(3):201-7. [Article]
  6. Chang H, Dmitrovsky E, Hieter PA, Mitchell K, Leder P, Turoczi L, Kirsch IR, Hollis GF: Identification of three new Ig lambda-like genes in man. J Exp Med. 1986 Feb 1;163(2):425-35. [Article]
  7. Minegishi Y, Coustan-Smith E, Wang YH, Cooper MD, Campana D, Conley ME: Mutations in the human lambda5/14.1 gene result in B cell deficiency and agammaglobulinemia. J Exp Med. 1998 Jan 5;187(1):71-7. [Article]
  8. Bankovich AJ, Raunser S, Juo ZS, Walz T, Davis MM, Garcia KC: Structural insight into pre-B cell receptor function. Science. 2007 Apr 13;316(5822):291-4. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB09130Copperapproved, investigationalunknownDetails