L-lactate dehydrogenase

Details

Name
L-lactate dehydrogenase
Synonyms
  • 1.1.1.27
  • L-LDH
Gene Name
ldh
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Amino acid sequence
>lcl|BSEQ0010922|L-lactate dehydrogenase
MKIGIVGLGRVGSSTAFALLMKGFAREMVLIDVDKKRAEGDALDLIHGTPFTRRANIYAG
DYADLKGSDVVIVAAGVPQKPGETRLQLLGRNARVMKEIARNVSKYAPDSIVIVVTNPVD
VLTYFFLKESGMDPRKVFGSGTVLDTARLRTLIAQHCGFSPRSVHVYVIGEHGDSEVPVW
SGAMIGGIPLQNMCQICQKCDSKILENFAEKTKRAAYEIIERKGATHYAIALAVADIVES
IFFDEKRVLTLSVYLEDYLGVKDLCISVPVTLGKHGVERILELNLNEEELEAFRKSASIL
KNAINEITAEENKHQNTSG
Number of residues
319
Molecular Weight
34994.11
Theoretical pI
7.16
GO Classification
Functions
L-lactate dehydrogenase activity / L-malate dehydrogenase activity
Processes
glycolytic process / malate metabolic process
Components
cytoplasm
General Function
L-malate dehydrogenase activity
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0010923|L-lactate dehydrogenase (ldh)
ATGAAAATAGGTATCGTAGGACTCGGAAGGGTTGGTTCCAGCACGGCTTTTGCACTCCTG
ATGAAAGGTTTTGCGAGGGAAATGGTTCTGATAGACGTCGATAAGAAAAGAGCAGAAGGA
GACGCTCTCGATCTCATTCACGGAACACCTTTCACGAGAAGAGCGAACATCTACGCTGGA
GACTATGCGGATCTGAAAGGATCAGATGTGGTGATCGTCGCTGCGGGAGTACCTCAGAAA
CCAGGAGAGACGAGGCTTCAGCTTCTTGGGAGAAATGCAAGAGTGATGAAAGAAATAGCG
CGAAACGTCTCCAAATACGCTCCTGATTCGATTGTCATCGTGGTCACGAATCCCGTCGAT
GTCCTCACGTATTTCTTCCTCAAAGAGTCCGGAATGGATCCCAGGAAGGTGTTCGGTTCC
GGAACGGTTCTCGACACAGCAAGGCTCAGAACTTTGATAGCGCAACACTGCGGCTTTTCT
CCAAGAAGTGTGCACGTGTACGTGATAGGAGAACATGGAGATTCAGAGGTTCCTGTGTGG
AGCGGTGCCATGATAGGAGGTATCCCCCTACAGAACATGTGTCAGATTTGTCAGAAGTGC
GATTCGAAGATACTGGAAAACTTCGCTGAAAAAACCAAAAGAGCCGCGTACGAGATCATA
GAGAGAAAGGGAGCCACCCATTACGCCATAGCTCTCGCCGTGGCCGACATAGTGGAGAGC
ATCTTCTTCGACGAAAAGAGAGTGCTTACGCTTTCCGTTTATCTCGAAGATTACCTCGGT
GTAAAAGATCTCTGTATCAGTGTTCCTGTTACCCTTGGAAAGCACGGAGTGGAAAGAATC
CTCGAACTGAACCTGAACGAAGAAGAACTGGAAGCCTTCAGAAAGTCAGCTTCCATATTG
AAAAACGCCATCAACGAAATAACGGCCGAAGAGAACAAGCACCAGAACACCAGCGGTTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP16115
UniProtKB Entry NameLDH_THEMA
GenBank Protein ID396281
GenBank Gene IDX74302
General References
  1. Ostendorp R, Liebl W, Schurig H, Jaenicke R: The L-lactate dehydrogenase gene of the hyperthermophilic bacterium Thermotoga maritima cloned by complementation in Escherichia coli. Eur J Biochem. 1993 Sep 15;216(3):709-15. [Article]
  2. Nelson KE, Clayton RA, Gill SR, Gwinn ML, Dodson RJ, Haft DH, Hickey EK, Peterson JD, Nelson WC, Ketchum KA, McDonald L, Utterback TR, Malek JA, Linher KD, Garrett MM, Stewart AM, Cotton MD, Pratt MS, Phillips CA, Richardson D, Heidelberg J, Sutton GG, Fleischmann RD, Eisen JA, White O, Salzberg SL, Smith HO, Venter JC, Fraser CM: Evidence for lateral gene transfer between Archaea and bacteria from genome sequence of Thermotoga maritima. Nature. 1999 May 27;399(6734):323-9. [Article]
  3. Wrba A, Jaenicke R, Huber R, Stetter KO: Lactate dehydrogenase from the extreme thermophile Thermotoga maritima. Eur J Biochem. 1990 Feb 22;188(1):195-201. [Article]
  4. Auerbach G, Ostendorp R, Prade L, Korndorfer I, Dams T, Huber R, Jaenicke R: Lactate dehydrogenase from the hyperthermophilic bacterium thermotoga maritima: the crystal structure at 2.1 A resolution reveals strategies for intrinsic protein stabilization. Structure. 1998 Jun 15;6(6):769-81. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB03940Oxamic AcidexperimentalunknownDetails