Adenylate kinase

Details

Name
Adenylate kinase
Synonyms
  • 2.7.4.3
  • Adenylate monophosphate kinase
  • AK
  • ATP-AMP transphosphorylase
  • ATP:AMP phosphotransferase
  • SOI16
  • Superoxide-inducible protein 16
Gene Name
adk
Organism
Bacillus subtilis (strain 168)
Amino acid sequence
>lcl|BSEQ0010862|Adenylate kinase
MNLVLMGLPGAGKGTQGERIVEDYGIPHISTGDMFRAAMKEETPLGLEAKSYIDKGELVP
DEVTIGIVKERLGKDDCERGFLLDGFPRTVAQAEALEEILEEYGKPIDYVINIEVDKDVL
MERLTGRRICSVCGTTYHLVFNPPKTPGICDKDGGELYQRADDNEETVSKRLEVNMKQTQ
PLLDFYSEKGYLANVNGQQDIQDVYADVKDLLGGLKK
Number of residues
217
Molecular Weight
24119.24
Theoretical pI
4.38
GO Classification
Functions
adenylate kinase activity / ATP binding / metal ion binding
Processes
AMP salvage
Components
cytoplasm
General Function
Metal ion binding
Specific Function
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0010863|Adenylate kinase (adk)
ATGAACTTAGTCTTAATGGGGCTTCCTGGTGCCGGTAAAGGCACACAGGGCGAACGAATT
GTTGAGGATTATGGGATTCCTCATATCTCAACAGGAGATATGTTCCGTGCTGCTATGAAA
GAAGAAACACCACTCGGACTCGAAGCAAAATCTTATATTGATAAGGGAGAGCTCGTACCT
GACGAAGTCACAATCGGAATTGTAAAAGAGAGACTTGGCAAAGATGATTGTGAAAGAGGT
TTTCTTCTGGACGGATTTCCGCGAACAGTCGCTCAAGCCGAAGCTCTTGAAGAAATTCTT
GAGGAATACGGCAAGCCGATTGATTATGTCATTAACATTGAAGTCGACAAAGATGTTCTG
ATGGAACGTCTGACTGGACGCAGAATTTGCAGTGTTTGCGGCACAACCTATCATTTAGTC
TTTAATCCGCCGAAAACGCCGGGTATTTGTGATAAAGACGGAGGCGAACTCTATCAACGG
GCAGATGATAATGAGGAAACAGTCTCTAAACGGCTTGAGGTAAACATGAAGCAAACTCAG
CCTTTACTCGATTTCTATTCAGAGAAAGGTTATCTTGCAAACGTGAATGGCCAGCAGGAC
ATTCAAGACGTTTATGCAGATGTGAAGGATCTTCTTGGAGGATTAAAAAAATGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP16304
UniProtKB Entry NameKAD_BACSU
GenBank Protein ID216340
GenBank Gene IDD00619
General References
  1. Nakamura K, Nakamura A, Takamatsu H, Yoshikawa H, Yamane K: Cloning and characterization of a Bacillus subtilis gene homologous to E. coli secY. J Biochem. 1990 Apr;107(4):603-7. [Article]
  2. Suh JW, Boylan SA, Oh SH, Price CW: Genetic and transcriptional organization of the Bacillus subtilis spc-alpha region. Gene. 1996 Feb 22;169(1):17-23. [Article]
  3. Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A, Borchert S, Borriss R, Boursier L, Brans A, Braun M, Brignell SC, Bron S, Brouillet S, Bruschi CV, Caldwell B, Capuano V, Carter NM, Choi SK, Cordani JJ, Connerton IF, Cummings NJ, Daniel RA, Denziot F, Devine KM, Dusterhoft A, Ehrlich SD, Emmerson PT, Entian KD, Errington J, Fabret C, Ferrari E, Foulger D, Fritz C, Fujita M, Fujita Y, Fuma S, Galizzi A, Galleron N, Ghim SY, Glaser P, Goffeau A, Golightly EJ, Grandi G, Guiseppi G, Guy BJ, Haga K, Haiech J, Harwood CR, Henaut A, Hilbert H, Holsappel S, Hosono S, Hullo MF, Itaya M, Jones L, Joris B, Karamata D, Kasahara Y, Klaerr-Blanchard M, Klein C, Kobayashi Y, Koetter P, Koningstein G, Krogh S, Kumano M, Kurita K, Lapidus A, Lardinois S, Lauber J, Lazarevic V, Lee SM, Levine A, Liu H, Masuda S, Mauel C, Medigue C, Medina N, Mellado RP, Mizuno M, Moestl D, Nakai S, Noback M, Noone D, O'Reilly M, Ogawa K, Ogiwara A, Oudega B, Park SH, Parro V, Pohl TM, Portelle D, Porwollik S, Prescott AM, Presecan E, Pujic P, Purnelle B, Rapoport G, Rey M, Reynolds S, Rieger M, Rivolta C, Rocha E, Roche B, Rose M, Sadaie Y, Sato T, Scanlan E, Schleich S, Schroeter R, Scoffone F, Sekiguchi J, Sekowska A, Seror SJ, Serror P, Shin BS, Soldo B, Sorokin A, Tacconi E, Takagi T, Takahashi H, Takemaru K, Takeuchi M, Tamakoshi A, Tanaka T, Terpstra P, Togoni A, Tosato V, Uchiyama S, Vandebol M, Vannier F, Vassarotti A, Viari A, Wambutt R, Wedler H, Weitzenegger T, Winters P, Wipat A, Yamamoto H, Yamane K, Yasumoto K, Yata K, Yoshida K, Yoshikawa HF, Zumstein E, Yoshikawa H, Danchin A: The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature. 1997 Nov 20;390(6657):249-56. [Article]
  4. Yoshikawa H, Doi RH: Sequence of the Bacillus subtilis spectinomycin resistance gene region. Nucleic Acids Res. 1990 Mar 25;18(6):1647. [Article]
  5. Suh JW, Boylan SA, Thomas SM, Dolan KM, Oliver DB, Price CW: Isolation of a secY homologue from Bacillus subtilis: evidence for a common protein export pathway in eubacteria. Mol Microbiol. 1990 Feb;4(2):305-14. [Article]
  6. Antelmann H, Bernhardt J, Schmid R, Mach H, Volker U, Hecker M: First steps from a two-dimensional protein index towards a response-regulation map for Bacillus subtilis. Electrophoresis. 1997 Aug;18(8):1451-63. [Article]
  7. Glaser P, Presecan E, Delepierre M, Surewicz WK, Mantsch HH, Barzu O, Gilles AM: Zinc, a novel structural element found in the family of bacterial adenylate kinases. Biochemistry. 1992 Mar 31;31(12):3038-43. [Article]
  8. Bae E, Phillips GN Jr: Structures and analysis of highly homologous psychrophilic, mesophilic, and thermophilic adenylate kinases. J Biol Chem. 2004 Jul 2;279(27):28202-8. Epub 2004 Apr 20. [Article]
  9. Counago R, Chen S, Shamoo Y: In vivo molecular evolution reveals biophysical origins of organismal fitness. Mol Cell. 2006 May 19;22(4):441-9. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01717Bis(Adenosine)-5'-PentaphosphateexperimentalunknownDetails