Chymotrypsinogen B

Details

Name
Chymotrypsinogen B
Synonyms
  • 3.4.21.1
  • CTRB
Gene Name
CTRB1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0017133|Chymotrypsinogen B
MAFLWLLSCWALLGTTFGCGVPAIHPVLSGLSRIVNGEDAVPGSWPWQVSLQDKTGFHFC
GGSLISEDWVVTAAHCGVRTSDVVVAGEFDQGSDEENIQVLKIAKVFKNPKFSILTVNND
ITLLKLATPARFSQTVSAVCLPSADDDFPAGTLCATTGWGKTKYNANKTPDKLQQAALPL
LSNAECKKSWGRRITDVMICAGASGVSSCMGDSGGPLVCQKDGAWTLVGIVSWGSDTCST
SSPGVYARVTKLIPWVQKILAAN
Number of residues
263
Molecular Weight
27869.74
Theoretical pI
7.17
GO Classification
Functions
serine-type endopeptidase activity
Processes
cobalamin metabolic process / digestion / extracellular matrix disassembly / extracellular matrix organization / small molecule metabolic process / vitamin metabolic process / water-soluble vitamin metabolic process
Components
extracellular region / extracellular space
General Function
Serine-type endopeptidase activity
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Chromosome Location
Not Available
Locus
16q23-q24.1
External Identifiers
ResourceLink
UniProtKB IDP17538
UniProtKB Entry NameCTRB1_HUMAN
GenBank Gene IDBC005385
GenAtlas IDCTRB1
HGNC IDHGNC:2521
General References
  1. Tomita N, Izumoto Y, Horii A, Doi S, Yokouchi H, Ogawa M, Mori T, Matsubara K: Molecular cloning and nucleotide sequence of human pancreatic prechymotrypsinogen cDNA. Biochem Biophys Res Commun. 1989 Jan 31;158(2):569-75. [Article]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01963Phenylethane Boronic AcidexperimentalunknownDetails
DB03976PhosphorylisopropaneexperimentalunknownDetails
DB06692Aprotininapproved, investigational, withdrawnunknownDetails
DB073801,1,1-TRIFLUORO-3-ACETAMIDO-4-PHENYL BUTAN-2-ONE(N-ACETYL-L-PHENYLALANYL TRIFLUOROMETHYL KETONE)experimentalunknownDetails
DB07383N-(1-BENZYL-3,3,3-TRIFLUORO-2,2-DIHYDROXY-PROPYL)-ACETAMIDEexperimentalunknownDetails
DB07668alpha-Methyl-2-hydroxy-4-diethylaminocinnamic acidexperimentalunknownDetails
DB077492-ACETYLAMINO-4-METHYL-PENTANOIC ACID (1-FORMYL-2-PHENYL-ETHYL)-AMIDEexperimentalunknownDetails
DB07899(2S) N-acetyl-L-alanyl-αL-phenylalanyl-chloroethylketoneexperimentalunknownDetails
DB081191,1,1-TRIFLUORO-3-((N-ACETYL)-L-LEUCYLAMIDO)-4-PHENYL-BUTAN-2-ONE(N-ACETYL-L-LEUCYL-L-PHENYLALANYL TRIFLUOROMETHYL KETONE)experimentalunknownDetails
DB01662Trans-O-Hydroxy-Alpha-Methyl CinnamateexperimentalunknownDetails
DB08374PhenylalanylmethylchlorideexperimentalunknownDetails
DB017042,4-Dihydroxy-Trans Cinnamic AcidexperimentalunknownDetails
DB08565L-1-naphthyl-2-acetamido-ethane boronic acidexperimentalunknownDetails
DB08566D-1-naphthyl-2-acetamido-ethane boronic acidexperimentalunknownDetails
DB08692D-1-(4-chlorophenyl)-2-(acetamido)ethane boronic acidexperimentalunknownDetails
DB08693L-1-(4-chlorophenyl)-2-(acetamido)ethane boronic acidexperimentalunknownDetails