D-2-hydroxyisocaproate dehydrogenase
Details
- Name
- D-2-hydroxyisocaproate dehydrogenase
- Synonyms
- 1.1.1.-
- D-HICDH
- Gene Name
- Not Available
- Organism
- Lactobacillus paracasei
- Amino acid sequence
>lcl|BSEQ0016585|D-2-hydroxyisocaproate dehydrogenase MKIIAYGARVDEIQYFKQWAKDTGNTLEYHTEFLDENTVEWAKGFDGINSLQTTPYAAGV FEKMHAYGIKFLTIRNVGTDNIDMTAMKQYGIRLSNVPAYSPAAIAEFALTDTLYLLRNM GKVQAQLQAGDYEKAGTFIGKELGQQTVGVMGTGHIGQVAIKLFKGFGAKVIAYDPYPMK GDHPDFDYVSLEDLFKQSDVIDLHVPGIEQNTHIINEAAFNLMKPGAIVINTARPNLIDT QAMLSNLKSGKLAGVGIDTYEYETEDLLNLAKHGSFKDPLWDELLGMPNVVLSPHIAYYT ETAVHNMVYFSLQHLVDFLTKGETSTEVTGPAK
- Number of residues
- 333
- Molecular Weight
- 36892.78
- Theoretical pI
- 5.05
- GO Classification
- FunctionsNAD binding / oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
- General Function
- Oxidoreductase activity, acting on the ch-oh group of donors, nad or nadp as acceptor
- Specific Function
- Catalyzes the NAD dependent reversible, stereospecific interconversion between 2-ketocarboxylic acids and D-2-hydroxy-carboxylic acids.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0003696|1008 bp ATGAAGATTATTGCTTACGGTGCTCGCGTTGACGAGATTCAATATTTCAAGCAATGGGCC AAGGATACAGGCAACACACTTGAATACCATACAGAATTTCTCGATGAAAACACCGTTGAA TGGGCTAAAGGGTTTGATGGCATCAATTCATTGCAGACAACGCCATATGCAGCCGGCGTT TTTGAAAAAATGCACGCGTATGGTATCAAGTTCTTGACGATTCGGAATGTGGGTACGGAT AACATTGATATGACTGCCATGAAGCAATACGGCATTCGTTTGAGCAATGTACCGGCTTAT TCGCCAGCAGCGATTGCTGAATTTGCTTTGACCGATACTTTGTACTTGCTACGTAATATG GGTAAAGTACAGGCGCAACTACAGGCGGGCGATTATGAAAAAGCGGGCACCTTCATCGGT AAGGAACTCGGTCAGCAAACCGTTGGCGTGATGGGCACCGGTCATATTGGACAGGTTGCT ATCAAACTGTTCAAAGGCTTTGGCGCCAAAGTGATTGCTTACGATCCTTATCCAATGAAG GGCGATCACCCAGATTTTGACTATGTCAGCCTTGAAGACCTCTTTAAGCAAAGTGATGTC ATTGATCTTCATGTTCCTGGGATTGAACAAAATACCCACATTATCAATGAAGCGGCATTT AATTTGATGAAACCGGGTGCGATTGTGATCAACACGGCTCGGCCAAATCTGATTGACACG CAAGCCATGCTCAGCAATCTTAAGTCTGGCAAGTTGGCCGGTGTCGGGATTGACACCTAT GAATACGAAACCGAGGACTTGTTGAATCTCGCCAAGCACGGCAGCTTCAAGGATCCGTTG TGGGACGAGCTGTTGGGGATGCCAAATGTTGTCCTCAGCCCGCACATTGCCTACTACACC GAGACGGCTGTGCATAATATGGTTTACTTCTCACTACAACATCTCGTTGATTTCTTGACC AAATTCAAACCAGCACGGAAGTTACTGGTCCAGCAAGTAGTCAACTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P17584 UniProtKB Entry Name DHD2_LACPA GenBank Protein ID 149538 GenBank Gene ID M26929 - General References
- Lerch HP, Blocker H, Kallwass H, Hoppe J, Tsai H, Collins J: Cloning, sequencing and expression in Escherichia coli of the D-2-hydroxyisocaproate dehydrogenase gene of Lactobacillus casei. Gene. 1989 May 15;78(1):47-57. [Article]
- Dengler U, Niefind K, Kiess M, Schomburg D: Crystal structure of a ternary complex of D-2-hydroxyisocaproate dehydrogenase from Lactobacillus casei, NAD+ and 2-oxoisocaproate at 1.9 A resolution. J Mol Biol. 1997 Apr 4;267(3):640-60. [Article]