Fumarate reductase iron-sulfur subunit

Details

Name

Fumarate reductase iron-sulfur subunit

Synonyms

• 1.3.5.1

Gene Name

frdB

Organism

Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W)

Amino acid sequence

>lcl|BSEQ0017311|Fumarate reductase iron-sulfur subunit
MGRMLTIRVFKYDPQSAVSKPHFQEYKIEEAPSMTIFIVLNMIRETYDPDLNFDFVCRAG
ICGSCGMMINGRPSLACRTLTKDFEDGVITLLPLPAFKLIKDLSVDTGNWFNGMSQRVES
WIHAQKEHDISKLEERIEPEVAQEVFELDRCIECGCCIAACGTKIMREDFVGAAGLNRVV
RFMIDPHDERTDEDYYELIGDDDGVFGCMTLLACHDVCPKNLPLQSKIAYLRRKMVSVN

Number of residues

239

Molecular Weight

27165.13

Theoretical pI

4.81

GO Classification

Functions

2 iron, 2 sulfur cluster binding / 3 iron, 4 sulfur cluster binding / 4 iron, 4 sulfur cluster binding / electron carrier activity / metal ion binding / succinate dehydrogenase (ubiquinone) activity

Processes

tricarboxylic acid cycle

Components

respiratory chain

General Function

Succinate dehydrogenase (ubiquinone) activity

Specific Function

The fumarate reductase enzyme complex is required for fumarate respiration using formate or sulfide as electron donor.

Pfam Domain Function

• Fer2_3 (PF13085)
• Fer4_8 (PF13183)

Transmembrane Regions

Not Available

Cellular Location

Not Available

Gene sequence

>lcl|BSEQ0017312|Fumarate reductase iron-sulfur subunit (frdB)
ATGGGAAGAATGCTAACCATCAGGGTTTTTAAATATGACCCCCAAAGTGCGGTTTCTAAG
CCCCACTTTCAAGAATACAAAATTGAAGAAGCGCCCTCGATGACGATTTTTATCGTCCTC
AACATGATTCGCGAGACCTACGATCCCGATTTGAACTTCGACTTCGTTTGCCGCGCAGGA
ATTTGCGGAAGCTGCGGCATGATGATCAATGGTCGTCCAAGCCTAGCTTGCCGAACCTTG
ACTAAAGATTTTGAGGATGGCGTGATCACGCTTCTTCCTTTGCCCGCTTTCAAACTCATC
AAAGACCTCTCCGTGGATACAGGAAACTGGTTCAACGGTATGAGTCAGCGAGTGGAGAGT
TGGATTCACGCTCAAAAAGAGCATGACATCTCCAAGCTTGAGGAAAGAATCGAGCCCGAA
GTTGCCCAAGAGGTTTTCGAGCTTGACCGATGTATCGAATGCGGCTGCTGCATCGCAGCT
TGCGGAACTAAGATCATGCGAGAAGACTTTGTCGGCGCGGCTGGACTCAACCGTGTCGTT
CGCTTTATGATTGATCCACACGATGAGCGAACCGATGAAGACTACTATGAACTCATCGGA
GATGATGATGGAGTCTTTGGTTGTATGACACTTTTGGCTTGCCACGATGTCTGCCCCAAA
AACCTCCCCTTGCAAAGCAAGATCGCTTACCTTCGAAGAAAAATGGTCAGCGTCAACTAA

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	P17596
UniProtKB Entry Name	FRDB_WOLSU
GenBank Protein ID	2281995
GenBank Gene ID	AJ000662

General References

1. Lauterbach F, Kortner C, Albracht SP, Unden G, Kroger A: The fumarate reductase operon of Wolinella succinogenes. Sequence and expression of the frdA and frdB genes. Arch Microbiol. 1990;154(4):386-93. [Article]
2. Simon J, Gross R, Ringel M, Schmidt E, Kroger A: Deletion and site-directed mutagenesis of the Wolinella succinogenes fumarate reductase operon. Eur J Biochem. 1998 Jan 15;251(1-2):418-26. [Article]
3. Baar C, Eppinger M, Raddatz G, Simon J, Lanz C, Klimmek O, Nandakumar R, Gross R, Rosinus A, Keller H, Jagtap P, Linke B, Meyer F, Lederer H, Schuster SC: Complete genome sequence and analysis of Wolinella succinogenes. Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11690-5. Epub 2003 Sep 19. [Article]
4. Lancaster CR, Kroger A, Auer M, Michel H: Structure of fumarate reductase from Wolinella succinogenes at 2.2 A resolution. Nature. 1999 Nov 25;402(6760):377-85. [Article]
5. Lancaster CR, Gross R, Simon J: A third crystal form of Wolinella succinogenes quinol:fumarate reductase reveals domain closure at the site of fumarate reduction. Eur J Biochem. 2001 Mar;268(6):1820-7. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB07669	2,3-Dimethyl-1,4-naphthoquinone	experimental	unknown		Details