Synapsin-1
Details
- Name
- Synapsin-1
- Synonyms
- Brain protein 4.1
- Synapsin I
- Gene Name
- SYN1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0009409|Synapsin-1 MNYLRRRLSDSNFMANLPNGYMTDLQRPQPPPPPPGAHSPGATPGPGTATAERSSGVAPA ASPAAPSPGSSGGGGFFSSLSNAVKQTTAAAAATFSEQVGGGSGGAGRGGAASRVLLVID EPHTDWAKYFKGKKIHGEIDIKVEQAEFSDLNLVAHANGGFSVDMEVLRNGVKVVRSLKP DFVLIRQHAFSMARNGDYRSLVIGLQYAGIPSVNSLHSVYNFCDKPWVFAQMVRLHKKLG TEEFPLIDQTFYPNHKEMLSSTTYPVVVKMGHAHSGMGKVKVDNQHDFQDIASVVALTKT YATAEPFIDAKYDVRVQKIGQNYKAYMRTSVSGNWKTNTGSAMLEQIAMSDRYKLWVDTC SEIFGGLDICAVEALHGKDGRDHIIEVVGSSMPLIGDHQDEDKQLIVELVVNKMAQALPR QRQRDASPGRGSHGQTPSPGALPLGRQTSQQPAGPPAQQRPPPQGGPPQPGPGPQRQGPP LQQRPPPQGQQHLSGLGPPAGSPLPQRLPSPTSAPQQPASQAAPPTQGQGRQSRPVAGGP GAPPAARPPASPSPQRQAGPPQATRQTSVSGPAPPKASGAPPGGQQRQGPPQKPPGPAGP TRQASQAGPVPRTGPPTTQQPRPSGPGPAGRPKPQLAQKPSQDVPPPATAAAGGPPHPQL NKSQSLTNAFNLPEPAPPRPSLSQDEVKAETIRSLRKSFASLFSD
- Number of residues
- 705
- Molecular Weight
- 74110.97
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / catalytic activity / protein kinase binding / transporter activityProcessesneurotransmitter secretion / regulation of neurotransmitter secretion / regulation of synaptic vesicle exocytosis / synaptic transmissionComponentscell junction / cytosol / dendrite / Golgi apparatus / myelin sheath / presynaptic active zone / synaptic vesicle / synaptic vesicle membrane / terminal bouton
- General Function
- Transporter activity
- Specific Function
- Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cell junction
- Gene sequence
>lcl|BSEQ0021388|Synapsin-1 (SYN1) ATGAACTACCTGCGGCGCCGCCTGTCGGACAGCAACTTTATGGCCAATCTGCCAAATGGG TACATGACAGACCTGCAGCGTCCGCAGCCGCCCCCACCGCCGCCCGGTGCCCACAGCCCC GGAGCCACGCCCGGTCCCGGGACCGCCACTGCCGAGAGGTCCTCCGGGGTCGCCCCAGCG GCCTCTCCGGCCGCCCCTAGCCCCGGGTCCTCGGGGGGCGGTGGCTTCTTCTCGTCGCTG TCCAACGCGGTCAAGCAGACCACGGCGGCGGCAGCTGCCACCTTCAGCGAGCAGGTGGGC GGCGGCTCTGGGGGCGCAGGCCGCGGGGGAGCCGCCTCCAGGGTGCTGCTGGTCATCGAC GAGCCGCACACCGACTGGGCAAAATACTTCAAAGGGAAAAAGATCCATGGAGAAATTGAC ATTAAAGTAGAACAGGCCGAATTCTCTGATCTCAACCTTGTGGCCCATGCCAATGGTGGA TTCTCTGTGGATATGGAAGTTCTTCGGAATGGGGTGAAGGTCGTGCGGTCTCTGAAGCCG GATTTTGTGCTGATCCGCCAGCACGCCTTCAGCATGGCACGCAACGGAGACTACCGCAGT TTGGTCATTGGGCTGCAGTATGCTGGAATCCCCAGTGTTAACTCCTTGCATTCTGTCTAC AACTTCTGTGACAAGCCCTGGGTGTTTGCCCAGATGGTTCGACTGCATAAGAAACTGGGG ACAGAAGAATTCCCTCTAATTGATCAGACCTTCTACCCCAATCACAAAGAAATGCTCAGC AGTACAACGTACCCCGTGGTTGTGAAGATGGGGCACGCACACTCTGGGATGGGCAAGGTC AAGGTTGACAACCAGCATGACTTCCAGGACATCGCAAGTGTCGTGGCACTGACCAAGACG TATGCCACTGCCGAGCCCTTCATCGATGCCAAATATGACGTGCGTGTCCAGAAGATTGGG CAGAACTACAAGGCCTACATGAGGACGTCAGTGTCAGGGAACTGGAAGACCAATACTGGC TCTGCGATGCTGGAGCAAATTGCCATGTCTGACAGATACAAGCTGTGGGTGGACACGTGC TCAGAGATTTTTGGGGGACTGGACATCTGCGCAGTGGAAGCGCTACATGGCAAGGACGGA AGGGATCACATCATTGAGGTGGTGGGTTCCTCCATGCCGCTCATTGGTGACCACCAGGAT GAAGACAAACAGCTCATCGTAGAGCTCGTGGTCAACAAGATGGCTCAGGCCCTGCCCCGG CAGCGACAGCGGGATGCCTCCCCTGGCAGGGGCTCCCATGGCCAGACTCCGTCCCCAGGG GCCCTGCCCTTGGGCCGCCAGACCTCCCAGCAGCCCGCAGGGCCCCCGGCTCAGCAGCGA CCCCCACCACAGGGCGGCCCTCCACAGCCGGGTCCAGGCCCCCAGCGCCAGGGACCCCCA TTGCAGCAGCGCCCGCCCCCGCAGGGCCAGCAGCACCTTTCAGGCCTTGGACCCCCAGCT GGCAGCCCCCTGCCCCAGCGCCTTCCAAGTCCCACCTCAGCGCCCCAGCAGCCCGCGTCC CAGGCCGCGCCGCCGACCCAGGGTCAAGGCCGCCAATCCCGGCCAGTGGCGGGAGGCCCC GGGGCGCCTCCAGCAGCCCGCCCGCCCGCCTCTCCGTCTCCCCAGCGCCAGGCGGGCCCC CCACAGGCTACCCGTCAGACATCCGTCTCTGGCCCGGCTCCGCCAAAGGCCTCTGGGGCC CCACCGGGCGGGCAGCAGCGCCAGGGCCCGCCCCAGAAACCCCCAGGCCCAGCCGGCCCC ACACGCCAGGCCAGCCAGGCGGGTCCCGTGCCCCGCACTGGGCCACCCACCACGCAGCAG CCTCGGCCCAGCGGCCCGGGCCCCGCTGGACGTCCCAAACCACAGCTGGCCCAGAAACCC AGCCAGGACGTGCCGCCACCCGCCACCGCCGCTGCAGGGGGACCTCCGCACCCCCAGCTC AACAAATCCCAGTCTCTGACCAATGCCTTCAACCTTCCAGAGCCAGCCCCGCCCAGGCCC AGCCTTAGCCAGGACGAGGTGAAAGCTGAGACCATCCGCAGCCTGAGGAAGTCTTTCGCC AGCCTCTTCTCCGACTGA
- Chromosome Location
- X
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P17600 UniProtKB Entry Name SYN1_HUMAN HGNC ID HGNC:11494 - General References
- Sudhof TC: The structure of the human synapsin I gene and protein. J Biol Chem. 1990 May 15;265(14):7849-52. [Article]
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- Sauerwald A, Hoesche C, Oschwald R, Kilimann MW: The 5'-flanking region of the synapsin I gene. A G+C-rich, TATA- and CAAT-less, phylogenetically conserved sequence with cell type-specific promoter function. J Biol Chem. 1990 Sep 5;265(25):14932-7. [Article]
- Garcia CC, Blair HJ, Seager M, Coulthard A, Tennant S, Buddles M, Curtis A, Goodship JA: Identification of a mutation in synapsin I, a synaptic vesicle protein, in a family with epilepsy. J Med Genet. 2004 Mar;41(3):183-6. [Article]
- DeGiorgis JA, Jaffe H, Moreira JE, Carlotti CG Jr, Leite JP, Pant HC, Dosemeci A: Phosphoproteomic analysis of synaptosomes from human cerebral cortex. J Proteome Res. 2005 Mar-Apr;4(2):306-15. [Article]
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