Cyclic AMP-dependent transcription factor ATF-3

Details

Name
Cyclic AMP-dependent transcription factor ATF-3
Synonyms
  • Activating transcription factor 3
  • cAMP-dependent transcription factor ATF-3
Gene Name
ATF3
Organism
Humans
Amino acid sequence
>lcl|BSEQ0008699|Cyclic AMP-dependent transcription factor ATF-3
MMLQHPGQVSASEVSASAIVPCLSPPGSLVFEDFANLTPFVKEELRFAIQNKHLCHRMSS
ALESVTVSDRPLGVSITKAEVAPEEDERKKRRRERNKIAAAKCRNKKKEKTECLQKESEK
LESVNAELKAQIEELKNEKQHLIYMLNLHRPTCIVRAQNGRTPEDERNLFIQQIKEGTLQ
S
Number of residues
181
Molecular Weight
20575.45
Theoretical pI
Not Available
GO Classification
Functions
DNA binding transcription factor activity / identical protein binding / protein heterodimerization activity / protein homodimerization activity / RNA polymerase II proximal promoter sequence-specific DNA binding / RNA polymerase II regulatory region sequence-specific DNA binding / transcription corepressor activity / transcription regulatory region DNA binding / transcription regulatory region sequence-specific DNA binding / transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding / transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
Processes
cellular response to amino acid starvation / gluconeogenesis / negative regulation of ERK1 and ERK2 cascade / negative regulation of transcription from RNA polymerase II promoter / PERK-mediated unfolded protein response / positive regulation of cell proliferation / positive regulation of TRAIL-activated apoptotic signaling pathway / positive regulation of transcription from RNA polymerase II promoter / positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress / regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance / skeletal muscle cell differentiation
Components
CHOP-ATF3 complex / nucleolus / nucleoplasm / nucleus
General Function
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.
Specific Function
Dna binding transcription factor activity
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0013362|Cyclic AMP-dependent transcription factor ATF-3 (ATF3)
ATGATGCTTCAACACCCAGGCCAGGTCTCTGCCTCGGAAGTGAGTGCTTCTGCCATCGTC
CCCTGCCTGTCCCCTCCTGGGTCACTGGTGTTTGAGGATTTTGCTAACCTGACGCCCTTT
GTCAAGGAAGAGCTGAGGTTTGCCATCCAGAACAAGCACCTCTGCCACCGGATGTCCTCT
GCGCTGGAATCAGTCACTGTCAGCGACAGACCCCTCGGGGTGTCCATCACAAAAGCCGAG
GTAGCCCCTGAAGAAGATGAAAGGAAAAAGAGGCGACGAGAAAGAAATAAGATTGCAGCT
GCAAAGTGCCGAAACAAGAAGAAGGAGAAGACGGAGTGCCTGCAGAAAGAGTCGGAGAAG
CTGGAAAGTGTGAATGCTGAACTGAAGGCTCAGATTGAGGAGCTCAAGAACGAGAAGCAG
CATTTGATATACATGCTCAACCTTCATCGGCCCACGTGTATTGTCCGGGCTCAGAATGGG
AGGACTCCAGAAGATGAGAGAAACCTCTTTATCCAACAGATAAAAGAAGGAACATTGCAG
AGCTAA
Chromosome Location
1
Locus
1q32.3
External Identifiers
ResourceLink
UniProtKB IDP18847
UniProtKB Entry NameATF3_HUMAN
HGNC IDHGNC:785
General References
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  3. Pan Y, Chen H, Siu F, Kilberg MS: Amino acid deprivation and endoplasmic reticulum stress induce expression of multiple activating transcription factor-3 mRNA species that, when overexpressed in HepG2 cells, modulate transcription by the human asparagine synthetase promoter. J Biol Chem. 2003 Oct 3;278(40):38402-12. Epub 2003 Jul 24. [PubMed:12881527]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00852PseudoephedrineapprovedunknowninhibitorDetails