Alkyl hydroperoxide reductase subunit F
Details
- Name
- Alkyl hydroperoxide reductase subunit F
- Synonyms
- 1.8.1.-
- Alkyl hydroperoxide reductase F52A protein
- Gene Name
- ahpF
- Organism
- Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
- Amino acid sequence
>lcl|BSEQ0019359|Alkyl hydroperoxide reductase subunit F MLDTNMKTQLRAYLEKLTKPVELIATLDDSAKSAEIKELLAEIAELSDKVTFKEDNTLPV RKPSFLITNPGSQQGPRFAGSPLGHEFTSLVLALLWTGGHPSKEAQSLLEQIRDIDGDFE FETYYSLSCHNCPDVVQALNLMAVLNPRIKHTAIDGGTFQNEITERNVMGVPAVFVNGKE FGQGRMTLTEIVAKVDTGAEKRAAEALNKRDAYDVLIVGSGPAGAAAAVYSARKGIRTGL MGERFGGQVLDTVDIENYISVPKTEGQKLAGALKAHVSDYDVDVIDSQSASKLVPAATEG GLHQIETASGAVLKARSIIIATGAKWRNMNVPGEDQYRTKGVTYCPHCDGPLFKGKRVAV IGGGNSGVEAAIDLAGIVEHVTLLEFAPEMKADQVLQDKVRSLKNVDIILNAQTTEVKGD GSKVVGLEYRDRVSGDIHSVALAGIFVQIGLLPNTHWLEGALERNRMGEIIIDAKCETSV KGVFAAGDCTTVPYKQIIIATGEGAKASLSAFDYLIRTKIA
- Number of residues
- 521
- Molecular Weight
- 55949.41
- Theoretical pI
- 5.69
- GO Classification
- Functionsalkyl hydroperoxide reductase activity / electron carrier activity / flavin adenine dinucleotide binding / NAD binding / protein disulfide oxidoreductase activityProcessescell redox homeostasis / response to reactive oxygen speciesComponentscell
- General Function
- Protein disulfide oxidoreductase activity
- Specific Function
- Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0019360|Alkyl hydroperoxide reductase subunit F (ahpF) ATGCTCGACACAAATATGAAAACCCAGCTCAGGGCTTACCTTGAGAAACTGACCAAACCT GTTGAGCTGATTGCCACGCTGGATGACAGCGCTAAATCGGCGGAAATCAAGGAACTGCTG GCTGAAATCGCCGAGCTGTCCGACAAAGTCACGTTTAAAGAAGACAATACTCTGCCGGTG CGCAAGCCGTCTTTCCTGATTACGAATCCAGGTTCTCAGCAAGGGCCGCGCTTTGCCGGT TCTCCGCTGGGCCACGAATTTACCTCGCTGGTTTTGGCGCTGCTGTGGACCGGCGGTCAT CCGTCAAAAGAAGCGCAGTCGCTGCTGGAGCAGATTCGCGATATTGACGGCGATTTTGAA TTCGAAACTTATTATTCACTCTCCTGCCATAACTGCCCGGACGTAGTGCAGGCGCTGAAC CTGATGGCGGTGCTGAACCCGCGTATTAAACATACGGCAATTGATGGCGGCACCTTCCAG AACGAAATCACCGAACGTAACGTGATGGGCGTTCCGGCGGTATTTGTTAACGGTAAAGAG TTCGGCCAGGGACGTATGACTCTGACCGAGATTGTCGCTAAAGTGGATACTGGCGCAGAA AAACGCGCGGCGGAAGCGCTGAACAAACGCGATGCGTATGACGTACTGATTGTCGGCTCC GGCCCGGCGGGCGCGGCGGCGGCGGTCTACTCGGCGCGCAAAGGCATCCGTACCGGTCTG ATGGGCGAGCGCTTCGGCGGTCAGGTGCTGGATACCGTGGATATCGAAAACTATATCTCG GTGCCGAAAACCGAAGGCCAGAAACTGGCGGGCGCGCTGAAAGCGCATGTCAGCGATTAC GACGTTGACGTTATCGACAGCCAGAGCGCAAGTAAACTGGTTCCGGCCGCAACAGAAGGC GGCTTGCATCAGATTGAAACGGCGTCCGGCGCAGTATTGAAAGCGCGTAGTATCATCATC GCCACCGGCGCGAAATGGCGCAATATGAATGTGCCGGGCGAGGATCAGTATCGCACCAAA GGCGTCACCTATTGTCCGCACTGCGACGGTCCGTTATTTAAAGGGAAGCGTGTGGCGGTC ATCGGCGGCGGCAACTCTGGCGTTGAAGCGGCTATCGATCTGGCAGGTATTGTAGAACAT GTTACGTTGCTGGAGTTCGCGCCGGAGATGAAGGCGGATCAGGTGCTACAGGACAAAGTG CGTAGTCTGAAAAATGTCGATATCATTTTGAATGCGCAAACGACAGAAGTGAAGGGCGAC GGTTCGAAAGTGGTGGGACTGGAGTATCGTGACCGTGTCAGCGGCGATATTCATAGCGTC GCGCTGGCAGGGATTTTTGTGCAGATTGGTCTGTTGCCGAATACCCACTGGCTGGAAGGC GCGCTTGAGCGTAACCGCATGGGCGAGATCATTATTGACGCCAAATGTGAAACCAGCGTT AAGGGCGTCTTCGCCGCAGGCGATTGCACCACCGTTCCTTACAAACAGATTATCATCGCC ACGGGCGAAGGGGCGAAAGCCTCGTTGAGCGCCTTTGATTATCTGATTCGCACCAAAATC GCATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P19480 UniProtKB Entry Name AHPF_SALTY GenBank Gene ID AE008724 - General References
- Tartaglia LA, Storz G, Brodsky MH, Lai A, Ames BN: Alkyl hydroperoxide reductase from Salmonella typhimurium. Sequence and homology to thioredoxin reductase and other flavoprotein disulfide oxidoreductases. J Biol Chem. 1990 Jun 25;265(18):10535-40. [Article]
- McClelland M, Sanderson KE, Spieth J, Clifton SW, Latreille P, Courtney L, Porwollik S, Ali J, Dante M, Du F, Hou S, Layman D, Leonard S, Nguyen C, Scott K, Holmes A, Grewal N, Mulvaney E, Ryan E, Sun H, Florea L, Miller W, Stoneking T, Nhan M, Waterston R, Wilson RK: Complete genome sequence of Salmonella enterica serovar Typhimurium LT2. Nature. 2001 Oct 25;413(6858):852-6. [Article]
- Jacobson FS, Morgan RW, Christman MF, Ames BN: An alkyl hydroperoxide reductase from Salmonella typhimurium involved in the defense of DNA against oxidative damage. Purification and properties. J Biol Chem. 1989 Jan 25;264(3):1488-96. [Article]