Inter-alpha-trypsin inhibitor heavy chain H1
Details
- Name
- Inter-alpha-trypsin inhibitor heavy chain H1
- Synonyms
- IGHEP1
- Inter-alpha-trypsin inhibitor complex component III
- ITI heavy chain H1
- Serum-derived hyaluronan-associated protein
- SHAP
- Gene Name
- ITIH1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0049870|Inter-alpha-trypsin inhibitor heavy chain H1 MDGAMGPRGLLLCMYLVSLLILQAMPALGSATGRSKSSEKRQAVDTAVDGVFIRSLKVNC KVTSRFAHYVVTSQVVNTANEAREVAFDLEIPKTAFISDFAVTADGNAFIGDIKDKVTAW KQYRKAAISGENAGLVRASGRTMEQFTIHLTVNPQSKVTFQLTYEEVLKRNHMQYEIVIK VKPKQLVHHFEIDVDIFEPQGISKLDAQASFLPKELAAQTIKKSFSGKKGHVLFRPTVSQ QQSCPTCSTSLLNGHFKVTYDVSRDKICDLLVANNHFAHFFAPQNLTNMNKNVVFVIDIS GSMRGQKVKQTKEALLKILGDMQPGDYFDLVLFGTRVQSWKGSLVQASEANLQAAQDFVR GFSLDEATNLNGGLLRGIEILNQVQESLPELSNHASILIMLTDGDPTEGVTDRSQILKNV RNAIRGRFPLYNLGFGHNVDFNFLEVMSMENNGRAQRIYEDHDATQQLQGFYSQVAKPLL VDVDLQYPQDAVLALTQNHHKQYYEGSEIVVAGRIADNKQSSFKADVQAHGEGQEFSITC LVDEEEMKKLLRERGHMLENHVERLWAYLTIQELLAKRMKVDREERANLSSQALQMSLDY GFVTPLTSMSIRGMADQDGLKPTIDKPSEDSPPLEMLGPRRTFVLSALQPSPTHSSSNTQ RLPDRVTGVDTDPHFIIHVPQKEDTLCFNINEEPGVILSLVQDPNTGFSVNGQLIGNKAR SPGQHDGTYFGRLGIANPATDFQLEVTPQNITLNPGFGGPVFSWRDQAVLRQDGVVVTIN KKRNLVVSVDDGGTFEVVLHRVWKGSSVHQDFLGFYVLDSHRMSARTHGLLGQFFHPIGF EVSDIHPGSDPTKPDATMVVRNRRLTVTRGLQKDYSKDPWHGAEVSCWFIHNNGAGLIDG AYTDYIVPDIF
- Number of residues
- 911
- Molecular Weight
- 101388.49
- Theoretical pI
- Not Available
- GO Classification
- Functionscalcium ion binding / serine-type endopeptidase inhibitor activityProcesseshyaluronan metabolic processComponentsblood microparticle / extracellular exosome / extracellular region
- General Function
- May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.
- Specific Function
- Calcium ion binding
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0049871|Inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1) ATGGACGGTGCCATGGGGCCTCGGGGGCTGCTGTTGTGCATGTACCTGGTATCTCTCCTC ATCCTGCAGGCCATGCCTGCCCTGGGCTCGGCTACAGGCAGGTCCAAGAGCAGCGAGAAG CGACAGGCTGTGGACACCGCTGTCGATGGCGTGTTCATCCGGAGTTTGAAAGTCAACTGC AAAGTCACCTCTCGCTTCGCCCACTATGTTGTCACCAGCCAAGTGGTCAACACTGCCAAT GAAGCCAGGGAAGTGGCCTTCGACCTGGAAATCCCCAAGACAGCATTCATCAGTGACTTT GCCGTTACAGCAGATGGAAACGCATTTATCGGAGACATAAAGGACAAGGTGACTGCATGG AAGCAGTACCGGAAAGCAGCTATCTCAGGAGAGAATGCCGGCCTTGTCAGGGCCTCGGGG AGAACTATGGAGCAATTCACCATCCACCTCACCGTCAATCCCCAGAGCAAGGTCACGTTT CAGCTGACTTATGAGGAAGTGCTGAAGAGAAACCATATGCAGTATGAAATTGTCATCAAA GTCAAGCCCAAGCAGCTGGTGCATCATTTTGAGATTGATGTGGACATCTTCGAGCCCCAG GGGATCAGCAAGCTGGATGCCCAGGCCTCTTTCCTGCCGAAGGAACTGGCAGCCCAAACT ATCAAGAAGTCCTTCTCAGGAAAAAAGGGTCATGTGCTGTTCCGTCCCACCGTGAGCCAG CAGCAGTCCTGCCCCACATGCTCTACATCCTTACTGAACGGGCACTTCAAGGTGACCTAC GATGTCAGTCGAGACAAGATCTGCGACCTCCTGGTGGCCAATAACCACTTTGCCCACTTC TTTGCCCCCCAAAACCTGACAAACATGAACAAGAACGTGGTTTTTGTGATTGACATCAGT GGCTCCATGAGAGGCCAGAAAGTGAAGCAGACCAAGGAGGCACTCCTTAAAATTCTGGGG GACATGCAGCCAGGGGACTACTTTGACCTGGTTCTTTTTGGGACTCGAGTACAATCGTGG AAGGGCTCGCTGGTGCAAGCATCTGAGGCCAACCTACAAGCAGCTCAAGACTTTGTGCGG GGCTTTTCCCTGGATGAGGCCACAAACCTGAATGGAGGTTTGCTCCGGGGAATTGAGATC TTGAACCAAGTTCAGGAAAGCCTCCCAGAACTCAGCAACCATGCCTCAATACTCATCATG TTGACAGATGGCGATCCCACAGAGGGGGTGACGGACCGTTCCCAAATCCTCAAGAACGTC CGCAACGCCATCCGGGGCAGGTTCCCGCTCTACAACCTGGGTTTCGGCCACAATGTGGAC TTTAACTTTCTGGAGGTCATGTCCATGGAGAACAACGGACGGGCCCAGAGAATCTACGAG GACCATGATGCCACCCAGCAGCTGCAGGGTTTCTACAGCCAGGTAGCCAAACCCCTGCTG GTGGATGTGGATTTGCAGTACCCCCAGGATGCTGTCTTGGCCCTGACCCAGAACCACCAT AAACAGTACTACGAAGGCTCAGAGATTGTGGTGGCCGGGCGCATTGCTGACAACAAACAG AGCAGCTTCAAGGCTGATGTGCAGGCCCATGGGGAGGGACAAGAATTCAGTATAACCTGC CTAGTGGATGAGGAGGAGATGAAGAAACTGCTCCGAGAGCGTGGCCACATGCTGGAGAAC CACGTCGAGCGCCTCTGGGCCTACCTCACCATCCAGGAGCTGCTGGCCAAGCGGATGAAG GTGGACAGGGAGGAGAGGGCCAACCTGTCATCCCAGGCCCTGCAGATGTCGCTGGACTAT GGGTTTGTGACCCCACTGACCTCCATGAGCATCAGGGGCATGGCGGACCAGGACGGCCTG AAGCCCACCATCGACAAGCCCTCAGAGGATTCTCCGCCTTTGGAGATGCTGGGACCCAGA AGGACGTTCGTGCTGTCAGCCTTGCAGCCTTCTCCTACTCATTCCAGCTCCAATACCCAG CGGCTGCCAGACCGAGTGACCGGCGTGGACACAGACCCTCACTTCATCATCCACGTGCCC CAGAAAGAGGACACCCTGTGCTTCAACATCAATGAGGAGCCTGGTGTTATCCTGAGCCTG GTACAGGACCCCAACACAGGCTTCTCAGTGAATGGACAGCTCATTGGCAACAAGGCCAGG AGCCCTGGGCAGCATGACGGCACGTACTTCGGGCGGCTGGGAATCGCAAACCCTGCCACG GACTTTCAGTTGGAAGTGACTCCTCAGAACATTACGCTGAACCCCGGCTTTGGTGGGCCT GTGTTTTCCTGGAGGGACCAAGCTGTGCTGCGGCAGGACGGGGTGGTGGTGACCATCAAC AAGAAGAGGAACCTGGTGGTGTCTGTGGACGACGGTGGCACCTTTGAGGTTGTTTTGCAC CGAGTGTGGAAGGGGAGCTCGGTCCACCAGGACTTCCTGGGCTTCTATGTGCTGGACAGT CATCGGATGTCAGCCCGGACGCACGGGCTGCTGGGGCAATTTTTCCACCCCATCGGTTTT GAAGTGTCTGACATCCACCCAGGCTCTGACCCCACAAAGCCAGATGCCACGATGGTGGTG AGGAACCGCCGGCTCACGGTCACCAGGGGTTTGCAAAAAGACTACAGCAAGGACCCGTGG CATGGGGCCGAGGTGTCCTGCTGGTTCATTCACAACAATGGGGCTGGACTCATCGATGGT GCCTACACTGATTATATCGTCCCCGACATCTTCTGA
- Chromosome Location
- 3
- Locus
- 3p21.1
- External Identifiers
Resource Link UniProtKB ID P19827 UniProtKB Entry Name ITIH1_HUMAN HGNC ID HGNC:6166 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB01593 Zinc approved, investigational unknown Details DB09338 Mersalyl experimental unknown inducer Details DB14487 Zinc acetate approved, investigational unknown Details DB14533 Zinc chloride approved, investigational unknown binder Details DB14548 Zinc sulfate, unspecified form approved, experimental unknown binder Details