3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase

Details

Name
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase
Synonyms
  • 1.1.1.53
Gene Name
Not Available
Organism
Streptomyces exfoliatus
Amino acid sequence
>lcl|BSEQ0011100|3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase
MNDLSGKTVIITGGARGLGAEAARQAVAAGARVVLADVLDEEGAATARELGDAARYQHLD
VTIEEDWQRVVAYAREEFGSVDGLVNNAGISTGMFLETESVERFRKVVDINLTGVFIGMK
TVIPAMKDAGGGSIVNISSAAGLMGLALTSSYGASKWGVRGLSKLAAVELGTDRIRVNSV
HPGMTYTPMTAETGIRQGEGNYPNTPMGRVGNEPGEIAGAVVKLLSDTSSYVTGAELAVD
GGWTTGPTVKYVMGQ
Number of residues
255
Molecular Weight
26483.77
Theoretical pI
4.71
GO Classification
Functions
androstan-3-alpha,17-beta-diol dehydrogenase activity
Processes
C21-steroid hormone metabolic process
General Function
Androstan-3-alpha,17-beta-diol dehydrogenase activity
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP19992
UniProtKB Entry NameHSD_STREX
General References
  1. Marekov L, Krook M, Jornvall H: Prokaryotic 20 beta-hydroxysteroid dehydrogenase is an enzyme of the 'short-chain, non-metalloenzyme' alcohol dehydrogenase type. FEBS Lett. 1990 Jun 18;266(1-2):51-4. [Article]
  2. Ghosh D, Weeks CM, Grochulski P, Duax WL, Erman M, Rimsay RL, Orr JC: Three-dimensional structure of holo 3 alpha,20 beta-hydroxysteroid dehydrogenase: a member of a short-chain dehydrogenase family. Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10064-8. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB02329CarbenoxoloneexperimentalunknownDetails