Dihydrofolate reductase

Details

Name
Dihydrofolate reductase
Synonyms
  • 1.5.1.3
Gene Name
DFR1
Organism
Yeast
Amino acid sequence
>lcl|BSEQ0016383|Dihydrofolate reductase
MSKPNVAIIVAALKPALGIGYKGKMPWRLRKEIRYFKDVTTRTTKPNTRNAVIMGRKTWE
SIPQKFRPLPDRLNIILSRSYENKIIDDNIIHASSIESSLNLVSDVERVFIIGGAEIYNE
LINNSLVSHLLITEIEHPSPESIEMDTFLKFPLESWTKQPKSELQKFVGDTVLEDDIKEG
DFTYNYTLWTRK
Number of residues
192
Molecular Weight
22138.295
Theoretical pI
9.25
GO Classification
Functions
dihydrofolate reductase activity / NADP binding
Processes
glycine biosynthetic process / nucleotide biosynthetic process / one-carbon metabolic process / tetrahydrofolate biosynthetic process
General Function
Nadp binding
Specific Function
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0002586|579 bp
ATGCTGAAACCAAATGTTGCAATCATTGTCGCGGCATTAAAGCCTGCTTTGGGAATTGGA
TACAAAGGTAAAATGCCTTGGAGACTCCGTAAGGAAATAAGATATTTCAAAGACGTCACC
ACCAGAACAACGAAACCAAATACTCGTAATGCTGTTATTATGGGAAGAAAGACGTGGGAA
TCCATACCACAGAAGTTTAGACCTCTTCCAGATAGATTAAACATAATATTATCTAGATCA
TACGAAAATAAAATTATTGATGACAATATCATTCATGCCAGCTCAATTGAGTCGTCACTT
AATCTTGTATCTGATGTCGAAAGAGTTTTCATAATTGGAGGGGCAGAAATTTACAATGAA
TTGATAAATAATTCTTTAGTGAGTCATCTATTAATTACAGAAATCGAACATCCAAGCCCA
GAGTCTATTGAAATGGATACCTTTTTGAAATTCCCATTGGAAAGTTGGACCAAACAACCA
AAATCAGAGTTGCAGAAATTTGTTGGAGATACTGTATTAGAAGACGATATCAAGGAAGGT
GATTTTACCTATAATTATACGCTATGGACAAGAAAATAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP22906
UniProtKB Entry NameDYR_CANAX
GenBank Protein ID563852
GenBank Gene IDX78968
General References
  1. Daly S, Mastromei G, Yacoub A, Lorenzetti R: Sequence of a dihydrofolate reductase-encoding gene from Candida albicans. Gene. 1994 Sep 15;147(1):115-8. [Article]
  2. Baccanari DP, Tansik RL, Joyner SS, Fling ME, Smith PL, Freisheim JH: Characterization of Candida albicans dihydrofolate reductase. J Biol Chem. 1989 Jan 15;264(2):1100-7. [Article]
  3. Whitlow M, Howard AJ, Stewart D, Hardman KD, Kuyper LF, Baccanari DP, Fling ME, Tansik RL: X-ray crystallographic studies of Candida albicans dihydrofolate reductase. High resolution structures of the holoenzyme and an inhibited ternary complex. J Biol Chem. 1997 Nov 28;272(48):30289-98. [Article]
  4. Whitlow M, Howard AJ, Stewart D, Hardman KD, Chan JH, Baccanari DP, Tansik RL, Hong JS, Kuyper LF: X-Ray crystal structures of Candida albicans dihydrofolate reductase: high resolution ternary complexes in which the dihydronicotinamide moiety of NADPH is displaced by an inhibitor. J Med Chem. 2001 Aug 30;44(18):2928-32. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB019295-Chloryl-2,4,6-quinazolinetriamineexperimentalunknownDetails
DB019585-[4-Tert-Butylphenylsulfanyl]-2,4-QuinazolinediamineexperimentalunknownDetails
DB020015-(4-Morpholin-4-Yl-Phenylsulfanyl)-2,4-QuinazolinediamineexperimentalunknownDetails
DB024025-(4-Methoxyphenoxy)-2,4-QuinazolinediamineexperimentalunknownDetails
DB038142-(N-morpholino)ethanesulfonic acidexperimentalunknownDetails
DB041635-Phenylsulfanyl-2,4-QuinazolinediamineexperimentalunknownDetails
DB043065-[(4-Methylphenyl)Sulfanyl]-2,4-QuinazolinediamineexperimentalunknownDetails