Sensor protein FixL

Details

Name
Sensor protein FixL
Synonyms
  • 2.7.13.3
Gene Name
fixL
Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Amino acid sequence
>lcl|BSEQ0016493|Sensor protein FixL
MAPTRVTHPPDDGRGEHFRVRIEGFGVGTWDLDLKTWALDWSDTARTLLGIGQDQPASYD
LFLSRLEPDDRERVESAIKRVSERGGGFDVSFRVAGTSNAGQWIRARAGLIRDEAGTARH
LSGIFLDIDEEKQVEGALRTRETHLRSILHTIPDAMIVIDGHGIIQLFSTAAERLFGWSE
LEAIGQNVNILMPEPDRSRHDSYISRYRTTSDPHIIGIGRIVTGKRRDGTTFPMHLSIGE
MQSGGEPYFTGFVRDLTEHQQTQARLQELQSELVHVSRLSAMGEMASALAHELNQPLAAI
SNYMKGSRRLLAGSSDPNTPKVESALDRAAEQALRAGQIIRRLRDFVARGESEKRVESLS
KLIEEAGALGLAGAREQNVQLRFSLDPGADLVLADRVQIQQVLVNLFRNALEAMAQSQRR
ELVVTNTPAADDMIEVEVSDTGSGFQDDVIPNLFQTFFTTKDTGMGVGLSISRSIIEAHG
GRMWAESNASGGATFRFTLPAADEN
Number of residues
505
Molecular Weight
55651.92
Theoretical pI
5.38
GO Classification
Functions
ATP binding / metal ion binding / phosphorelay sensor kinase activity
Processes
nitrogen fixation / peptidyl-histidine phosphorylation / phosphorelay signal transduction system / regulation of transcription, DNA-templated / signal transduction by protein phosphorylation
Components
intracellular
General Function
Phosphorelay sensor kinase activity
Specific Function
Putative oxygen sensor; modulates the activity of FixJ, a transcriptional activator of nitrogen fixation fixK gene. FixL probably acts as a kinase that phosphorylates FixJ.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cell inner membrane; multi-pass membrane protein
Gene sequence
>lcl|BSEQ0016494|Sensor protein FixL (fixL)
TTGGCGCCGACCCGCGTAACGCATCCGCCGGATGACGGCCGGGGCGAGCATTTCCGGGTC
AGGATCGAGGGATTCGGCGTCGGCACCTGGGATCTCGACCTCAAGACCTGGGCGCTGGAC
TGGTCGGATACCGCGCGGACCCTGCTCGGAATCGGGCAGGACCAGCCGGCGAGCTACGAC
CTCTTCCTGTCACGCCTCGAGCCCGACGACCGCGAGCGCGTGGAGAGCGCGATCAAGCGC
GTCTCCGAACGCGGTGGCGGCTTCGACGTGTCCTTCAGGGTCGCCGGCACCTCCAACGCA
GGACAGTGGATTCGCGCCCGGGCCGGACTCATTCGGGACGAAGCCGGCACCGCCCGCCAT
CTCAGCGGCATCTTTCTCGATATCGACGAGGAGAAGCAGGTCGAGGGTGCGCTCCGTACC
CGCGAGACCCACCTCCGCTCGATCCTCCACACAATTCCCGACGCCATGATCGTCATCGAC
GGCCACGGCATCATCCAGCTGTTCAGCACCGCCGCCGAGCGCCTGTTCGGCTGGTCCGAG
CTCGAGGCGATCGGCCAGAACGTCAACATCCTGATGCCGGAGCCCGACCGCTCCCGGCAT
GACAGCTACATTTCGCGTTACCGCACCACGAGCGATCCCCACATCATCGGCATCGGGCGC
ATCGTGACCGGCAAGCGCCGCGACGGCACCACCTTCCCGATGCACCTGTCGATCGGCGAG
ATGCAGTCCGGCGGCGAGCCCTATTTTACCGGTTTCGTCCGCGATCTCACCGAGCACCAG
CAGACCCAGGCGCGTCTCCAGGAACTGCAATCCGAGCTCGTCCACGTCTCCAGGCTGAGC
GCCATGGGCGAAATGGCGTCCGCGCTCGCGCACGAGCTCAACCAGCCGCTGGCGGCGATC
AGCAACTACATGAAGGGCTCGCGGCGGCTGCTTGCCGGCAGCAGTGATCCGAACACACCG
AAGGTCGAAAGCGCCCTGGACCGCGCCGCCGAGCAGGCGCTGCGCGCCGGCCAGATCATC
CGGCGCCTGCGCGACTTCGTTGCCCGCGGCGAATCGGAGAAGCGGGTCGAGAGTCTCTCC
AAGCTGATCGAGGAGGCCGGCGCGCTCGGGCTTGCCGGCGCGCGCGAGCAGAACGTGCAG
CTCCGCTTCAGTCTCGATCCGGGCGCCGATCTCGTTCTCGCCGACCGGGTGCAGATCCAG
CAGGTCCTGGTCAACCTGTTCCGCAACGCGCTGGAAGCGATGGCTCAGTCGCAGCGACGC
GAGCTCGTCGTCACCAACACCCCCGCCGCCGACGACATGATCGAGGTCGAAGTGTCCGAC
ACCGGCAGCGGTTTCCAGGACGACGTCATTCCGAACCTGTTTCAGACTTTCTTCACCACC
AAGGACACCGGCATGGGCGTGGGACTGTCCATCAGCCGCTCGATCATCGAAGCTCACGGC
GGGCGCATGTGGGCCGAGAGCAACGCATCGGGCGGGGCGACCTTCCGCTTCACCCTCCCG
GCAGCCGACGAGAATTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP23222
UniProtKB Entry NameFIXL_BRADU
GenBank Protein ID39523
GenBank Gene IDX56808
General References
  1. Anthamatten D, Hennecke H: The regulatory status of the fixL- and fixJ-like genes in Bradyrhizobium japonicum may be different from that in Rhizobium meliloti. Mol Gen Genet. 1991 Jan;225(1):38-48. [Article]
  2. Kaneko T, Nakamura Y, Sato S, Minamisawa K, Uchiumi T, Sasamoto S, Watanabe A, Idesawa K, Iriguchi M, Kawashima K, Kohara M, Matsumoto M, Shimpo S, Tsuruoka H, Wada T, Yamada M, Tabata S: Complete genomic sequence of nitrogen-fixing symbiotic bacterium Bradyrhizobium japonicum USDA110. DNA Res. 2002 Dec 31;9(6):189-97. [Article]
  3. Gong W, Hao B, Mansy SS, Gonzalez G, Gilles-Gonzalez MA, Chan MK: Structure of a biological oxygen sensor: a new mechanism for heme-driven signal transduction. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15177-82. [Article]
  4. Gong W, Hao B, Chan MK: New mechanistic insights from structural studies of the oxygen-sensing domain of Bradyrhizobium japonicum FixL. Biochemistry. 2000 Apr 11;39(14):3955-62. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB026711-MethylimidazoleexperimentalunknownDetails
DB03366Imidazoleexperimental, investigationalunknownDetails