Kell blood group glycoprotein

Details

Name
Kell blood group glycoprotein
Synonyms
  • 3.4.24.-
Gene Name
KEL
Organism
Humans
Amino acid sequence
>lcl|BSEQ0049683|Kell blood group glycoprotein
MEGGDQSEEEPRERSQAGGMGTLWSQESTPEERLPVEGSRPWAVARRVLTAILILGLLLC
FSVLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCTDFFSFACGRAKETNNSFQE
LATKNKNRLRRILEVQNSWHPGSGEEKAFQFYNSCMDTLAIEAAGTGPLRQVIEELGGWR
ISGKWTSLNFNRTLRLLMSQYGHFPFFRAYLGPHPASPHTPVIQIDQPEFDVPLKQDQEQ
KIYAQIFREYLTYLNQLGTLLGGDPSKVQEHSSLSISITSRLFQFLRPLEQRRAQGKLFQ
MVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQSLVVHDVEYLKNMSQLVEEMLLKQRDF
LQSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRWMKCVEETGTFFEP
TLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRNLPWMNEETQNMAQDKVAQLQVEMG
ASEWALKPELARQEYNDIQLGSSFLQSVLSCVRSLRARIVQSFLQPHPQHRWKVSPWDVN
AYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIFYQLLLPGGCLACD
NHALQEAHLCLKRHYAAFPLPSRTSFNDSLTFLENAADVGGLAIALQAYSKRLLRHHGET
VLPSLDLSPQQIFFRSYAQVMCRKPSPQDSHDTHSPPHLRVHGPLSSTPAFARYFRCARG
ALLNPSSRCQLW
Number of residues
732
Molecular Weight
82823.095
Theoretical pI
Not Available
GO Classification
Functions
metal ion binding / metalloendopeptidase activity
Processes
cellular calcium ion homeostasis / cellular magnesium ion homeostasis / myelination / negative regulation of potassium ion transmembrane transport / regulation of axon diameter / skeletal muscle fiber development / vasoconstriction
Components
integral component of membrane / plasma membrane
General Function
Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3.
Specific Function
Metal ion binding
Pfam Domain Function
Transmembrane Regions
48-67
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0049684|Kell blood group glycoprotein (KEL)
ATGGAAGGTGGGGACCAAAGTGAGGAAGAGCCGAGGGAACGCAGCCAGGCAGGTGGAATG
GGAACTCTCTGGAGCCAAGAGAGCACTCCAGAAGAGAGGCTGCCCGTGGAAGGGAGCAGG
CCATGGGCAGTGGCCAGGCGGGTGCTGACAGCTATCCTGATTTTGGGCCTGCTCCTTTGT
TTTTCTGTGCTTTTGTTCTACAACTTCCAGAACTGTGGCCCTCGCCCCTGTGAGACATCT
GTGTGTTTGGATCTCCGGGATCATTACCTGGCCTCTGGGAACACAAGTGTGGCCCCCTGC
ACCGACTTCTTCAGCTTTGCCTGTGGAAGGGCCAAAGAGACCAATAATTCTTTTCAGGAG
CTTGCCACAAAGAACAAAAACCGACTTCGGAGAATACTGGAGGTCCAGAATTCCTGGCAC
CCAGGCTCTGGGGAGGAGAAAGCCTTCCAGTTCTACAACTCCTGCATGGATACACTTGCC
ATTGAAGCTGCAGGGACTGGTCCCCTCAGACAAGTTATTGAGGAGCTTGGAGGCTGGCGC
ATCTCTGGTAAATGGACTTCCTTAAACTTTAACCGAACGCTGAGACTTCTGATGAGTCAG
TATGGCCATTTCCCTTTCTTCAGAGCCTACCTAGGACCTCATCCTGCCTCTCCACACACA
CCAGTCATCCAGATAGACCAGCCAGAGTTTGATGTTCCCCTCAAGCAAGATCAAGAACAG
AAGATCTATGCCCAGATCTTTCGGGAATACCTGACTTACCTGAATCAGCTGGGAACCTTG
CTGGGAGGAGACCCAAGCAAGGTGCAAGAACACTCTTCCTTGTCAATCTCCATCACTTCA
CGGCTGTTCCAGTTTCTGAGGCCCCTGGAGCAGCGGCGGGCACAGGGCAAGCTCTTCCAG
ATGGTCACTATCGACCAGCTCAAGGAAATGGCCCCCGCCATCGACTGGTTGTCCTGCTTG
CAAGCGACATTCACACCGATGTCCCTGAGCCCTTCTCAGTCCCTCGTGGTCCATGACGTG
GAATATTTGAAAAACATGTCACAACTGGTGGAGGAGATGCTGCTAAAGCAGAGGGACTTT
CTGCAGAGCCACATGATCTTAGGGCTGGTGGTGACCCTTTCTCCAGCCCTGGACAGTCAA
TTCCAGGAGGCACGCAGAAAGCTCAGCCAGAAACTGCGGGAACTGACAGAGCAACCACCC
ATGCCTGCCCGCCCACGATGGATGAAGTGCGTGGAGGAGACAGGCACGTTCTTCGAGCCC
ACGCTGGCGGCTTTGTTTGTTCGTGAGGCCTTTGGCCCGAGCACCCGAAGTGCTGCCATG
AAATTATTCACTGCGATCCGGGATGCCCTCATCACTCGCCTCAGAAACCTTCCCTGGATG
AATGAGGAGACCCAGAACATGGCCCAGGACAAGGTTGCTCAACTGCAGGTGGAGATGGGG
GCTTCAGAATGGGCCCTGAAGCCAGAGCTGGCCCGACAAGAATACAACGATATACAGCTT
GGATCGAGCTTCCTGCAGTCTGTCCTGAGCTGTGTCCGGTCCCTCCGAGCTAGAATTGTC
CAGAGCTTCTTGCAGCCTCACCCCCAACACAGGTGGAAGGTGTCCCCTTGGGACGTCAAT
GCTTACTATTCGGTATCTGACCATGTGGTAGTCTTTCCAGCTGGACTCCTCCAACCCCCA
TTCTTCCACCCTGGCTATCCCAGAGCCGTGAACTTTGGCGCTGCTGGCAGCATCATGGCC
CACGAGCTGTTGCACATCTTCTACCAGCTCTTACTGCCTGGGGGCTGCCTCGCCTGTGAC
AACCATGCCCTCCAGGAAGCTCACCTGTGCCTGAAGCGCCATTATGCTGCCTTTCCATTA
CCTAGCAGAACCTCCTTCAATGACTCCCTCACATTCTTAGAGAATGCTGCAGACGTTGGG
GGGCTAGCCATCGCGCTGCAGGCATACAGCAAGAGGCTGTTACGGCACCATGGGGAGACT
GTCCTGCCCAGCCTGGACCTCAGCCCCCAGCAGATCTTCTTTCGAAGCTATGCCCAGGTG
ATGTGTAGGAAGCCCAGCCCCCAGGACTCTCACGACACTCACAGCCCTCCACACCTCCGA
GTCCACGGGCCCCTCAGCAGCACCCCAGCCTTTGCCAGGTATTTCCGCTGTGCACGTGGT
GCTCTCTTGAACCCCTCCAGCCGCTGCCAGCTCTGGTAA
Chromosome Location
7
Locus
7q34
External Identifiers
ResourceLink
UniProtKB IDP23276
UniProtKB Entry NameKELL_HUMAN
HGNC IDHGNC:6308
General References
  1. Lee S, Zambas ED, Marsh WL, Redman CM: Molecular cloning and primary structure of Kell blood group protein. Proc Natl Acad Sci U S A. 1991 Jul 15;88(14):6353-7. [Article]
  2. Lee S, Zambas E, Green ED, Redman C: Organization of the gene encoding the human Kell blood group protein. Blood. 1995 Mar 1;85(5):1364-70. [Article]
  3. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  5. Lee S, Wu X, Reid M, Redman C: Molecular basis of the K:6,-7 [Js(a+b-)] phenotype in the Kell blood group system. Transfusion. 1995 Oct;35(10):822-5. [Article]
  6. Russo D, Redman C, Lee S: Association of XK and Kell blood group proteins. J Biol Chem. 1998 May 29;273(22):13950-6. [Article]
  7. Lee S, Lin M, Mele A, Cao Y, Farmar J, Russo D, Redman C: Proteolytic processing of big endothelin-3 by the kell blood group protein. Blood. 1999 Aug 15;94(4):1440-50. [Article]
  8. Russo D, Wu X, Redman CM, Lee S: Expression of Kell blood group protein in nonerythroid tissues. Blood. 2000 Jul 1;96(1):340-6. [Article]
  9. Camara-Clayette V, Rahuel C, Lopez C, Hattab C, Verkarre V, Bertrand O, Cartron JP: Transcriptional regulation of the KEL gene and Kell protein expression in erythroid and non-erythroid cells. Biochem J. 2001 May 15;356(Pt 1):171-80. [Article]
  10. Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S: Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res. 2013 Jan 4;12(1):260-71. doi: 10.1021/pr300630k. Epub 2012 Dec 18. [Article]
  11. Lee S, Wu X, Reid M, Zelinski T, Redman C: Molecular basis of the Kell (K1) phenotype. Blood. 1995 Feb 15;85(4):912-6. [Article]
  12. Lee S, Wu X, Son S, Naime D, Reid M, Okubo Y, Sistonen P, Redman C: Point mutations characterize KEL10, the KEL3, KEL4, and KEL21 alleles, and the KEL17 and KEL11 alleles. Transfusion. 1996 Jun;36(6):490-4. [Article]
  13. Lee S, Naime D, Reid M, Redman C: The KEL24 and KEL14 alleles of the Kell blood group system. Transfusion. 1997 Oct;37(10):1035-8. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB02557PhosphoramidonexperimentalunknownDetails