Kell blood group glycoprotein
Details
- Name
- Kell blood group glycoprotein
- Synonyms
- 3.4.24.-
- Gene Name
- KEL
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0049683|Kell blood group glycoprotein MEGGDQSEEEPRERSQAGGMGTLWSQESTPEERLPVEGSRPWAVARRVLTAILILGLLLC FSVLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCTDFFSFACGRAKETNNSFQE LATKNKNRLRRILEVQNSWHPGSGEEKAFQFYNSCMDTLAIEAAGTGPLRQVIEELGGWR ISGKWTSLNFNRTLRLLMSQYGHFPFFRAYLGPHPASPHTPVIQIDQPEFDVPLKQDQEQ KIYAQIFREYLTYLNQLGTLLGGDPSKVQEHSSLSISITSRLFQFLRPLEQRRAQGKLFQ MVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQSLVVHDVEYLKNMSQLVEEMLLKQRDF LQSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRWMKCVEETGTFFEP TLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRNLPWMNEETQNMAQDKVAQLQVEMG ASEWALKPELARQEYNDIQLGSSFLQSVLSCVRSLRARIVQSFLQPHPQHRWKVSPWDVN AYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIFYQLLLPGGCLACD NHALQEAHLCLKRHYAAFPLPSRTSFNDSLTFLENAADVGGLAIALQAYSKRLLRHHGET VLPSLDLSPQQIFFRSYAQVMCRKPSPQDSHDTHSPPHLRVHGPLSSTPAFARYFRCARG ALLNPSSRCQLW
- Number of residues
- 732
- Molecular Weight
- 82823.095
- Theoretical pI
- Not Available
- GO Classification
- Functionsmetal ion binding / metalloendopeptidase activityProcessescellular calcium ion homeostasis / cellular magnesium ion homeostasis / myelination / negative regulation of potassium ion transmembrane transport / regulation of axon diameter / skeletal muscle fiber development / vasoconstrictionComponentsintegral component of membrane / plasma membrane
- General Function
- Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3.
- Specific Function
- Metal ion binding
- Pfam Domain Function
- Transmembrane Regions
- 48-67
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0049684|Kell blood group glycoprotein (KEL) ATGGAAGGTGGGGACCAAAGTGAGGAAGAGCCGAGGGAACGCAGCCAGGCAGGTGGAATG GGAACTCTCTGGAGCCAAGAGAGCACTCCAGAAGAGAGGCTGCCCGTGGAAGGGAGCAGG CCATGGGCAGTGGCCAGGCGGGTGCTGACAGCTATCCTGATTTTGGGCCTGCTCCTTTGT TTTTCTGTGCTTTTGTTCTACAACTTCCAGAACTGTGGCCCTCGCCCCTGTGAGACATCT GTGTGTTTGGATCTCCGGGATCATTACCTGGCCTCTGGGAACACAAGTGTGGCCCCCTGC ACCGACTTCTTCAGCTTTGCCTGTGGAAGGGCCAAAGAGACCAATAATTCTTTTCAGGAG CTTGCCACAAAGAACAAAAACCGACTTCGGAGAATACTGGAGGTCCAGAATTCCTGGCAC CCAGGCTCTGGGGAGGAGAAAGCCTTCCAGTTCTACAACTCCTGCATGGATACACTTGCC ATTGAAGCTGCAGGGACTGGTCCCCTCAGACAAGTTATTGAGGAGCTTGGAGGCTGGCGC ATCTCTGGTAAATGGACTTCCTTAAACTTTAACCGAACGCTGAGACTTCTGATGAGTCAG TATGGCCATTTCCCTTTCTTCAGAGCCTACCTAGGACCTCATCCTGCCTCTCCACACACA CCAGTCATCCAGATAGACCAGCCAGAGTTTGATGTTCCCCTCAAGCAAGATCAAGAACAG AAGATCTATGCCCAGATCTTTCGGGAATACCTGACTTACCTGAATCAGCTGGGAACCTTG CTGGGAGGAGACCCAAGCAAGGTGCAAGAACACTCTTCCTTGTCAATCTCCATCACTTCA CGGCTGTTCCAGTTTCTGAGGCCCCTGGAGCAGCGGCGGGCACAGGGCAAGCTCTTCCAG ATGGTCACTATCGACCAGCTCAAGGAAATGGCCCCCGCCATCGACTGGTTGTCCTGCTTG CAAGCGACATTCACACCGATGTCCCTGAGCCCTTCTCAGTCCCTCGTGGTCCATGACGTG GAATATTTGAAAAACATGTCACAACTGGTGGAGGAGATGCTGCTAAAGCAGAGGGACTTT CTGCAGAGCCACATGATCTTAGGGCTGGTGGTGACCCTTTCTCCAGCCCTGGACAGTCAA TTCCAGGAGGCACGCAGAAAGCTCAGCCAGAAACTGCGGGAACTGACAGAGCAACCACCC ATGCCTGCCCGCCCACGATGGATGAAGTGCGTGGAGGAGACAGGCACGTTCTTCGAGCCC ACGCTGGCGGCTTTGTTTGTTCGTGAGGCCTTTGGCCCGAGCACCCGAAGTGCTGCCATG AAATTATTCACTGCGATCCGGGATGCCCTCATCACTCGCCTCAGAAACCTTCCCTGGATG AATGAGGAGACCCAGAACATGGCCCAGGACAAGGTTGCTCAACTGCAGGTGGAGATGGGG GCTTCAGAATGGGCCCTGAAGCCAGAGCTGGCCCGACAAGAATACAACGATATACAGCTT GGATCGAGCTTCCTGCAGTCTGTCCTGAGCTGTGTCCGGTCCCTCCGAGCTAGAATTGTC CAGAGCTTCTTGCAGCCTCACCCCCAACACAGGTGGAAGGTGTCCCCTTGGGACGTCAAT GCTTACTATTCGGTATCTGACCATGTGGTAGTCTTTCCAGCTGGACTCCTCCAACCCCCA TTCTTCCACCCTGGCTATCCCAGAGCCGTGAACTTTGGCGCTGCTGGCAGCATCATGGCC CACGAGCTGTTGCACATCTTCTACCAGCTCTTACTGCCTGGGGGCTGCCTCGCCTGTGAC AACCATGCCCTCCAGGAAGCTCACCTGTGCCTGAAGCGCCATTATGCTGCCTTTCCATTA CCTAGCAGAACCTCCTTCAATGACTCCCTCACATTCTTAGAGAATGCTGCAGACGTTGGG GGGCTAGCCATCGCGCTGCAGGCATACAGCAAGAGGCTGTTACGGCACCATGGGGAGACT GTCCTGCCCAGCCTGGACCTCAGCCCCCAGCAGATCTTCTTTCGAAGCTATGCCCAGGTG ATGTGTAGGAAGCCCAGCCCCCAGGACTCTCACGACACTCACAGCCCTCCACACCTCCGA GTCCACGGGCCCCTCAGCAGCACCCCAGCCTTTGCCAGGTATTTCCGCTGTGCACGTGGT GCTCTCTTGAACCCCTCCAGCCGCTGCCAGCTCTGGTAA
- Chromosome Location
- 7
- Locus
- 7q34
- External Identifiers
Resource Link UniProtKB ID P23276 UniProtKB Entry Name KELL_HUMAN HGNC ID HGNC:6308 - General References
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