Cofilin-1

Details

Name
Cofilin-1
Synonyms
  • 18 kDa phosphoprotein
  • CFL
  • Cofilin, non-muscle isoform
  • p18
Gene Name
CFL1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0020747|Cofilin-1
MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDV
GQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS
KDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL
Number of residues
166
Molecular Weight
18502.315
Theoretical pI
8.29
GO Classification
Processes
actin cytoskeleton organization / actin filament depolymerization / axon guidance / blood coagulation / cytoskeleton organization / ephrin receptor signaling pathway / establishment of cell polarity / Fc-gamma receptor signaling pathway involved in phagocytosis / innate immune response / mitotic cytokinesis / negative regulation of apoptotic process / neural crest cell migration / neural fold formation / platelet activation / platelet degranulation / positive regulation of actin filament depolymerization / protein phosphorylation / regulation of cell morphogenesis / regulation of dendritic spine morphogenesis / response to amino acid / response to virus / Rho protein signal transduction
Components
cell-cell junction / cortical actin cytoskeleton / cytoplasm / extracellular exosome / extracellular space / focal adhesion / lamellipodium membrane / membrane / nuclear matrix / nucleus / ruffle membrane / vesicle
General Function
Not Available
Specific Function
Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus matrix
Gene sequence
>lcl|BSEQ0020748|Cofilin-1 (CFL1)
ATGGCCTCCGGTGTGGCTGTCTCTGATGGTGTCATCAAGGTGTTCAACGACATGAAGGTG
CGTAAGTCTTCAACGCCAGAGGAGGTGAAGAAGCGCAAGAAGGCGGTGCTCTTCTGCCTG
AGTGAGGACAAGAAGAACATCATCCTGGAGGAGGGCAAGGAGATCCTGGTGGGCGATGTG
GGCCAGACTGTCGACGACCCCTACGCCACCTTTGTCAAGATGCTGCCAGATAAGGACTGC
CGCTATGCCCTCTATGATGCAACCTATGAGACCAAGGAGAGCAAGAAGGAGGATCTGGTG
TTTATCTTCTGGGCCCCCGAGTCTGCGCCCCTTAAGAGCAAAATGATTTATGCCAGCTCC
AAGGACGCCATCAAGAAGAAGCTGACAGGGATCAAGCATGAATTGCAAGCAAACTGCTAC
GAGGAGGTCAAGGACCGCTGCACCCTGGCAGAGAAGCTGGGGGGCAGTGCCGTCATCTCC
CTGGAGGGCAAGCCTTTGTGA
Chromosome Location
11
Locus
11q13
External Identifiers
ResourceLink
UniProtKB IDP23528
UniProtKB Entry NameCOF1_HUMAN
GenBank Protein ID219545
GenBank Gene IDD00682
HGNC IDHGNC:1874
General References
  1. Ogawa K, Tashima M, Yumoto Y, Okuda T, Sawada H, Okuma M, Maruyama Y: Coding sequence of human placenta cofilin cDNA. Nucleic Acids Res. 1990 Dec 11;18(23):7169. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04147Dodecyldimethylamine N-oxideexperimentalunknownDetails
DB09130Copperapproved, investigationalunknownDetails
DB11638Artenimolapproved, experimental, investigationalunknownligandDetails