Methionyl-tRNA formyltransferase
Details
- Name
- Methionyl-tRNA formyltransferase
- Synonyms
- 2.1.2.9
- yhdD
- Gene Name
- fmt
- Organism
- Escherichia coli (strain K12)
- Amino acid sequence
>lcl|BSEQ0012845|Methionyl-tRNA formyltransferase MSESLRIIFAGTPDFAARHLDALLSSGHNVVGVFTQPDRPAGRGKKLMPSPVKVLAEEKG LPVFQPVSLRPQENQQLVAELQADVMVVVAYGLILPKAVLEMPRLGCINVHGSLLPRWRG AAPIQRSLWAGDAETGVTIMQMDVGLDTGDMLYKLSCPITAEDTSGTLYDKLAELGPQGL ITTLKQLADGTAKPEVQDETLVTYAEKLSKEEARIDWSLSAAQLERCIRAFNPWPMSWLE IEGQPVKVWKASVIDTATNAAPGTILEANKQGIQVATGDGILNLLSLQPAGKKAMSAQDL LNSRREWFVPGNRLV
- Number of residues
- 315
- Molecular Weight
- 34168.16
- Theoretical pI
- 5.45
- GO Classification
- Functionsmethionyl-tRNA formyltransferase activity / methyltransferase activityProcessescharged-tRNA amino acid modification / conversion of methionyl-tRNA to N-formyl-methionyl-tRNA / translational initiationComponentscytosol
- General Function
- Methyltransferase activity
- Specific Function
- Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0012846|Methionyl-tRNA formyltransferase (fmt) GTGTCAGAATCACTACGTATTATTTTTGCGGGTACACCTGACTTTGCAGCGCGTCATCTC GACGCGCTGTTGTCTTCTGGTCATAACGTCGTTGGCGTGTTCACCCAGCCAGACCGACCG GCAGGACGCGGTAAAAAACTGATGCCCAGCCCGGTTAAAGTTCTGGCTGAGGAAAAAGGT CTGCCCGTTTTTCAACCTGTTTCCCTGCGTCCACAAGAAAACCAGCAACTGGTCGCCGAA CTGCAGGCTGATGTTATGGTCGTCGTCGCCTATGGTTTAATTCTGCCGAAAGCAGTGCTG GAGATGCCGCGTCTTGGCTGTATCAACGTTCATGGTTCACTGCTGCCACGCTGGCGCGGT GCTGCACCAATCCAACGCTCACTATGGGCGGGTGATGCAGAAACTGGTGTGACCATTATG CAAATGGATGTCGGTTTAGACACCGGTGATATGCTCTATAAGCTCTCCTGCCCGATTACT GCAGAAGATACCAGTGGTACGCTGTACGACAAGCTGGCAGAGCTTGGCCCACAAGGGCTT ATCACCACGTTGAAACAACTGGCAGACGGCACGGCGAAACCAGAAGTTCAGGACGAAACT CTTGTCACTTACGCCGAGAAGTTGAGTAAAGAAGAAGCGCGTATTGACTGGTCACTTTCG GCAGCACAGCTTGAACGCTGCATTCGCGCTTTCAATCCATGGCCAATGAGCTGGCTGGAA ATTGAAGGACAGCCGGTTAAAGTCTGGAAAGCATCGGTCATTGATACGGCAACCAACGCT GCACCAGGAACGATCCTTGAAGCCAACAAACAAGGCATTCAGGTTGCGACTGGTGATGGC ATCCTGAACCTGCTCTCGTTACAACCTGCGGGTAAGAAAGCGATGAGCGCGCAAGACCTC CTGAACTCTCGTCGGGAATGGTTTGTTCCGGGCAACCGTCTGGTCTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P23882 UniProtKB Entry Name FMT_ECOLI GenBank Protein ID 41474 GenBank Gene ID X63666 - General References
- Guillon JM, Mechulam Y, Schmitter JM, Blanquet S, Fayat G: Disruption of the gene for Met-tRNA(fMet) formyltransferase severely impairs growth of Escherichia coli. J Bacteriol. 1992 Jul;174(13):4294-301. [Article]
- Meinnel T, Guillon JM, Mechulam Y, Blanquet S: The Escherichia coli fmt gene, encoding methionyl-tRNA(fMet) formyltransferase, escapes metabolic control. J Bacteriol. 1993 Feb;175(4):993-1000. [Article]
- Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. [Article]
- Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. Epub 2006 Feb 21. [Article]
- Mazel D, Pochet S, Marliere P: Genetic characterization of polypeptide deformylase, a distinctive enzyme of eubacterial translation. EMBO J. 1994 Feb 15;13(4):914-23. [Article]
- Meek DW, Hayward RS: Nucleotide sequence of the rpoA-rplQ DNA of Escherichia coli: a second regulatory binding site for protein S4? Nucleic Acids Res. 1984 Jul 25;12(14):5813-21. [Article]
- Mazel D, Coic E, Blanchard S, Saurin W, Marliere P: A survey of polypeptide deformylase function throughout the eubacterial lineage. J Mol Biol. 1997 Mar 14;266(5):939-49. [Article]
- VanBogelen RA, Abshire KZ, Moldover B, Olson ER, Neidhardt FC: Escherichia coli proteome analysis using the gene-protein database. Electrophoresis. 1997 Aug;18(8):1243-51. [Article]
- Schmitt E, Blanquet S, Mechulam Y: Structure of crystalline Escherichia coli methionyl-tRNA(f)Met formyltransferase: comparison with glycinamide ribonucleotide formyltransferase. EMBO J. 1996 Sep 2;15(17):4749-58. [Article]
- Schmitt E, Panvert M, Blanquet S, Mechulam Y: Crystal structure of methionyl-tRNAfMet transformylase complexed with the initiator formyl-methionyl-tRNAfMet. EMBO J. 1998 Dec 1;17(23):6819-26. [Article]