Insulin-like growth factor-binding protein 5
Details
- Name
- Insulin-like growth factor-binding protein 5
- Synonyms
- IBP-5
- IBP5
- Gene Name
- IGFBP5
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052014|Insulin-like growth factor-binding protein 5 MVLLTAVLLLLAAYAGPAQSLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCA LAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYREQVKIERDSREHE EPTTSEMAEETYSPKIFRPKHTRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRIISA PEMRQESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGI CWCVDKYGMKLPGMEYVDGDFQCHTFDSSNVE
- Number of residues
- 272
- Molecular Weight
- 30569.985
- Theoretical pI
- Not Available
- GO Classification
- Functionsfibronectin binding / insulin-like growth factor I binding / insulin-like growth factor II bindingProcessesaging / cellular protein metabolic process / cellular response to cAMP / cellular response to organic cyclic compound / female pregnancy / glucose homeostasis / glucose metabolic process / hair follicle morphogenesis / intracellular signal transduction / lung alveolus development / mammary gland involution / negative regulation of cell migration / negative regulation of growth / negative regulation of insulin-like growth factor receptor signaling pathway / negative regulation of muscle tissue development / negative regulation of osteoblast differentiation / negative regulation of skeletal muscle hypertrophy / negative regulation of smooth muscle cell migration / negative regulation of smooth muscle cell proliferation / negative regulation of translation / osteoblast differentiation / positive regulation of insulin-like growth factor receptor signaling pathway / positive regulation of protein kinase B signaling / positive regulation of vascular associated smooth muscle cell migration / positive regulation of vascular smooth muscle cell proliferation / post-translational protein modification / regulation of cell growth / regulation of glucose metabolic process / regulation of insulin-like growth factor receptor signaling pathway / response to growth hormone / signal transduction / striated muscle cell differentiation / type B pancreatic cell proliferationComponentsendoplasmic reticulum lumen / extracellular region / extracellular space / insulin-like growth factor binding protein complex / insulin-like growth factor ternary complex
- General Function
- IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
- Specific Function
- Fibronectin binding
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0052015|Insulin-like growth factor-binding protein 5 (IGFBP5) ATGGTGTTGCTCACCGCGGTCCTCCTGCTGCTGGCCGCCTATGCGGGGCCGGCCCAGAGC CTGGGCTCCTTCGTGCACTGCGAGCCCTGCGACGAGAAAGCCCTCTCCATGTGCCCCCCC AGCCCCCTGGGCTGCGAGCTGGTCAAGGAGCCGGGCTGCGGCTGCTGCATGACCTGCGCC CTGGCCGAGGGGCAGTCGTGCGGCGTCTACACCGAGCGCTGCGCCCAGGGGCTGCGCTGC CTCCCCCGGCAGGACGAGGAGAAGCCGCTGCACGCCCTGCTGCACGGCCGCGGGGTTTGC CTCAACGAAAAGAGCTACCGCGAGCAAGTCAAGATCGAGAGAGACTCCCGTGAGCACGAG GAGCCCACCACCTCTGAGATGGCCGAGGAGACCTACTCCCCCAAGATCTTCCGGCCCAAA CACACCCGCATCTCCGAGCTGAAGGCTGAAGCAGTGAAGAAGGACCGCAGAAAGAAGCTG ACCCAGTCCAAGTTTGTCGGGGGAGCCGAGAACACTGCCCACCCCCGGATCATCTCTGCA CCTGAGATGAGACAGGAGTCTGAGCAGGGCCCCTGCCGCAGACACATGGAGGCTTCCCTG CAGGAGCTCAAAGCCAGCCCACGCATGGTGCCCCGTGCTGTGTACCTGCCCAATTGTGAC CGCAAAGGATTCTACAAGAGAAAGCAGTGCAAACCTTCCCGTGGCCGCAAACGTGGCATC TGCTGGTGCGTGGACAAGTACGGGATGAAGCTGCCAGGCATGGAGTACGTTGACGGGGAC TTTCAGTGCCACACCTTCGACAGCAGCAACGTTGAGTGA
- Chromosome Location
- 2
- Locus
- 2q35
- External Identifiers
Resource Link UniProtKB ID P24593 UniProtKB Entry Name IBP5_HUMAN HGNC ID HGNC:5474 - General References
- Kiefer MC, Ioh RS, Bauer DM, Zapf J: Molecular cloning of a new human insulin-like growth factor binding protein. Biochem Biophys Res Commun. 1991 Apr 15;176(1):219-25. [Article]
- Shimasaki S, Shimonaka M, Zhang HP, Ling N: Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human. J Biol Chem. 1991 Jun 5;266(16):10646-53. [Article]
- Allander SV, Larsson C, Ehrenborg E, Suwanichkul A, Weber G, Morris SL, Bajalica S, Kiefer MC, Luthman H, Powell DR: Characterization of the chromosomal gene and promoter for human insulin-like growth factor binding protein-5. J Biol Chem. 1994 Apr 8;269(14):10891-8. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Andress DL, Birnbaum RS: A novel human insulin-like growth factor binding protein secreted by osteoblast-like cells. Biochem Biophys Res Commun. 1991 Apr 15;176(1):213-8. [Article]
- Standker L, Wobst P, Mark S, Forssmann WG: Isolation and characterization of circulating 13-kDa C-terminal fragments of human insulin-like growth factor binding protein-5. FEBS Lett. 1998 Dec 18;441(2):281-6. [Article]
- Nili M, Mukherjee A, Shinde U, David L, Rotwein P: Defining the disulfide bonds of insulin-like growth factor-binding protein-5 by tandem mass spectrometry with electron transfer dissociation and collision-induced dissociation. J Biol Chem. 2012 Jan 6;287(2):1510-9. doi: 10.1074/jbc.M111.285528. Epub 2011 Nov 22. [Article]
- Tagliabracci VS, Wiley SE, Guo X, Kinch LN, Durrant E, Wen J, Xiao J, Cui J, Nguyen KB, Engel JL, Coon JJ, Grishin N, Pinna LA, Pagliarini DJ, Dixon JE: A Single Kinase Generates the Majority of the Secreted Phosphoproteome. Cell. 2015 Jun 18;161(7):1619-32. doi: 10.1016/j.cell.2015.05.028. [Article]
- Kalus W, Zweckstetter M, Renner C, Sanchez Y, Georgescu J, Grol M, Demuth D, Schumacher R, Dony C, Lang K, Holak TA: Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions. EMBO J. 1998 Nov 16;17(22):6558-72. [Article]