C-X-C chemokine receptor type 1

Details

Name
C-X-C chemokine receptor type 1
Synonyms
  • CDw128a
  • CMKAR1
  • CXC-R1
  • High affinity interleukin-8 receptor A
  • IL-8 receptor type 1
  • IL-8R A
  • IL8RA
Gene Name
CXCR1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0012470|C-X-C chemokine receptor type 1
MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLV
MLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVN
FYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHP
NNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRA
MRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCL
NPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
Number of residues
350
Molecular Weight
39790.735
Theoretical pI
8.81
GO Classification
Functions
chemokine receptor activity / G-protein coupled receptor activity / interleukin-8 binding / interleukin-8 receptor activity
Processes
cell surface receptor signaling pathway / chemokine-mediated signaling pathway / chemotaxis / dendritic cell chemotaxis / G-protein coupled receptor signaling pathway / inflammatory response / interleukin-8-mediated signaling pathway / receptor internalization
Components
integral component of membrane / membrane / plasma membrane
General Function
Interleukin-8 receptor activity
Specific Function
Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.
Pfam Domain Function
Transmembrane Regions
40-66 76-96 112-133 155-174 200-220 243-264 286-308
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0012471|C-X-C chemokine receptor type 1 (CXCR1)
ATGTCAAATATTACAGATCCACAGATGTGGGATTTTGATGATCTAAATTTCACTGGCATG
CCACCTGCAGATGAAGATTACAGCCCCTGTATGCTAGAAACTGAGACACTCAACAAGTAT
GTTGTGATCATCGCCTATGCCCTAGTGTTCCTGCTGAGCCTGCTGGGAAACTCCCTGGTG
ATGCTGGTCATCTTATACAGCAGGGTCGGCCGCTCCGTCACTGATGTCTACCTGCTGAAC
CTGGCCTTGGCCGACCTACTCTTTGCCCTGACCTTGCCCATCTGGGCCGCCTCCAAGGTG
AATGGCTGGATTTTTGGCACATTCCTGTGCAAGGTGGTCTCACTCCTGAAGGAAGTCAAC
TTCTACAGTGGCATCCTGCTGTTGGCCTGCATCAGTGTGGACCGTTACCTGGCCATTGTC
CATGCCACACGCACACTGACCCAGAAGCGTCACTTGGTCAAGTTTGTTTGTCTTGGCTGC
TGGGGACTGTCTATGAATCTGTCCCTGCCCTTCTTCCTTTTCCGCCAGGCTTACCATCCA
AACAATTCCAGTCCAGTTTGCTATGAGGTCCTGGGAAATGACACAGCAAAATGGCGGATG
GTGTTGCGGATCCTGCCTCACACCTTTGGCTTCATCGTGCCGCTGTTTGTCATGCTGTTC
TGCTATGGATTCACCCTGCGTACACTGTTTAAGGCCCACATGGGGCAGAAGCACCGAGCC
ATGAGGGTCATCTTTGCTGTCGTCCTCATCTTCCTGCTTTGCTGGCTGCCCTACAACCTG
GTCCTGCTGGCAGACACCCTCATGAGGACCCAGGTGATCCAGGAGAGCTGTGAGCGCCGC
AACAACATCGGCCGGGCCCTGGATGCCACTGAGATTCTGGGATTTCTCCATAGCTGCCTC
AACCCCATCATCTACGCCTTCATCGGCCAAAATTTTCGCCATGGATTCCTCAAGATCCTG
GCTATGCATGGCCTGGTCAGCAAGGAGTTCTTGGCACGTCATCGTGTTACCTCCTACACT
TCTTCGTCTGTCAATGTCTCTTCCAACCTCTGA
Chromosome Location
2
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP25024
UniProtKB Entry NameCXCR1_HUMAN
GenBank Protein ID559050
GenBank Gene IDL19591
HGNC IDHGNC:6026
General References
  1. Holmes WE, Lee J, Kuang WJ, Rice GC, Wood WI: Structure and functional expression of a human interleukin-8 receptor. Science. 1991 Sep 13;253(5025):1278-80. [Article]
  2. Cerretti DP, Kozlosky CJ, Vanden Bos T, Nelson N, Gearing DP, Beckmann MP: Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2. Mol Immunol. 1993 Mar;30(4):359-67. [Article]
  3. Mollereau C, Muscatelli F, Mattei MG, Vassart G, Parmentier M: The high-affinity interleukin 8 receptor gene (IL8RA) maps to the 2q33-q36 region of the human genome: cloning of a pseudogene (IL8RBP) for the low-affinity receptor. Genomics. 1993 Apr;16(1):248-51. [Article]
  4. Ahuja SK, Shetty A, Tiffany HL, Murphy PM: Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B. J Biol Chem. 1994 Oct 21;269(42):26381-9. [Article]
  5. Liu Y, Yang S, Lin AA, Cavalli-Sforza LL, Su B: Molecular evolution of CXCR1, a G protein-coupled receptor involved in signal transduction of neutrophils. J Mol Evol. 2005 Nov;61(5):691-6. Epub 2005 Oct 4. [Article]
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  11. Skelton NJ, Quan C, Reilly D, Lowman H: Structure of a CXC chemokine-receptor fragment in complex with interleukin-8. Structure. 1999 Feb 15;7(2):157-68. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01009Ketoprofenapproved, vet_approvedunknownotherDetails