Orotidine 5'-phosphate decarboxylase
Details
- Name
- Orotidine 5'-phosphate decarboxylase
- Synonyms
- 4.1.1.23
- OMP decarboxylase
- OMPDCase
- OMPdecase
- Gene Name
- pyrF
- Organism
- Bacillus subtilis (strain 168)
- Amino acid sequence
>lcl|BSEQ0020574|Orotidine 5'-phosphate decarboxylase MKNNLPIIALDFASAEETLAFLAPFQQEPLFVKVGMELFYQEGPSIVKQLKERNCELFLD LKLHDIPTTVNKAMKRLASLGVDLVNVHAAGGKKMMQAALEGLEEGTPAGKKRPSLIAVT QLTSTSEQIMKDELLIEKSLIDTVVHYSKQAEESGLDGVVCSVHEAKAIYQAVSPSFLTV TPGIRMSEDAANDQVRVATPAIAREKGSSAIVVGRSITKAEDPVKAYKAVRLEWEGIKS
- Number of residues
- 239
- Molecular Weight
- 25991.84
- Theoretical pI
- 6.15
- GO Classification
- Functionsorotidine-5'-phosphate decarboxylase activityProcesses'de novo' pyrimidine nucleobase biosynthetic process / 'de novo' UMP biosynthetic process
- General Function
- Orotidine-5'-phosphate decarboxylase activity
- Specific Function
- Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
- Pfam Domain Function
- OMPdecase (PF00215)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0020575|Orotidine 5'-phosphate decarboxylase (pyrF) ATGAAAAACAACCTGCCCATCATCGCGCTTGATTTTGCGTCAGCTGAAGAAACACTTGCG TTCTTAGCGCCTTTTCAGCAAGAACCGTTATTTGTAAAGGTTGGGATGGAGCTTTTTTAT CAAGAAGGGCCATCTATCGTGAAACAACTAAAAGAAAGAAACTGCGAGCTATTTTTAGAT CTAAAGCTTCATGACATCCCGACTACTGTAAACAAAGCGATGAAGCGCCTTGCCAGTCTT GGAGTAGACCTCGTCAATGTTCATGCTGCCGGGGGCAAAAAAATGATGCAGGCAGCTCTC GAAGGCTTAGAAGAAGGTACGCCGGCTGGAAAAAAACGTCCGTCACTTATCGCGGTAACC CAGCTGACAAGCACATCTGAACAAATCATGAAAGATGAACTGCTGATCGAAAAGTCTCTG ATTGATACGGTTGTGCACTACAGCAAACAGGCGGAAGAAAGCGGACTGGATGGAGTGGTC TGCTCTGTTCATGAAGCAAAAGCCATTTACCAAGCGGTGTCGCCTTCATTTCTGACTGTC ACTCCGGGGATCAGAATGTCAGAGGACGCTGCGAATGACCAAGTTCGCGTAGCGACGCCT GCCATTGCAAGAGAGAAAGGTTCATCAGCGATTGTAGTAGGACGCTCGATTACAAAAGCG GAAGACCCGGTAAAAGCCTATAAGGCTGTCAGACTTGAATGGGAGGGAATCAAATCTTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P25971 UniProtKB Entry Name PYRF_BACSU GenBank Protein ID 143392 GenBank Gene ID M59757 - General References
- Quinn CL, Stephenson BT, Switzer RL: Functional organization and nucleotide sequence of the Bacillus subtilis pyrimidine biosynthetic operon. J Biol Chem. 1991 May 15;266(14):9113-27. [Article]
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- Appleby TC, Kinsland C, Begley TP, Ealick SE: The crystal structure and mechanism of orotidine 5'-monophosphate decarboxylase. Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2005-10. [Article]