Protein S100-A4

Details

Name
Protein S100-A4
Synonyms
  • Calvasculin
  • CAPL
  • Metastasin
  • MTS1
  • Placental calcium-binding protein
  • Protein Mts1
  • S100 calcium-binding protein A4
Gene Name
S100A4
Organism
Humans
Amino acid sequence
>lcl|BSEQ0013033|Protein S100-A4
MACPLEKALDVMVSTFHKYSGKEGDKFKLNKSELKELLTRELPSFLGKRTDEAAFQKLMS
NLDSNRDNEVDFQEYCVFLSCIAMMCNEFFEGFPDKQPRKK
Number of residues
101
Molecular Weight
11728.41
Theoretical pI
5.92
GO Classification
Functions
calcium ion binding / poly(A) RNA binding / RAGE receptor binding
Processes
epithelial to mesenchymal transition / positive regulation of I-kappaB kinase/NF-kappaB signaling
Components
extracellular exosome / extracellular space / neuron projection / nucleus / perinuclear region of cytoplasm
General Function
Rage receptor binding
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0013034|Protein S100-A4 (S100A4)
ATGGCGTGCCCTCTGGAGAAGGCCCTGGATGTGATGGTGTCCACCTTCCACAAGTACTCG
GGCAAAGAGGGTGACAAGTTCAAGCTCAACAAGTCAGAACTAAAGGAGCTGCTGACCCGG
GAGCTGCCCAGCTTCTTGGGGAAAAGGACAGATGAAGCTGCTTTCCAGAAGCTGATGAGC
AACTTGGACAGCAACAGGGACAACGAGGTGGACTTCCAAGAGTACTGTGTCTTCCTGTCC
TGCATCGCCATGATGTGTAACGAATTCTTTGAAGGCTTCCCAGATAAGCAGCCCAGGAAG
AAATGA
Chromosome Location
1
Locus
1q21
External Identifiers
ResourceLink
UniProtKB IDP26447
UniProtKB Entry NameS10A4_HUMAN
GenBank Protein ID179917
GenBank Gene IDM80563
HGNC IDHGNC:10494
General References
  1. Engelkamp D, Schafer BW, Erne P, Heizmann CW: S100 alpha, CAPL, and CACY: molecular cloning and expression analysis of three calcium-binding proteins from human heart. Biochemistry. 1992 Oct 27;31(42):10258-64. [Article]
  2. Engelkamp D, Schafer BW, Mattei MG, Erne P, Heizmann CW: Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E. Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6547-51. [Article]
  3. Tulchinsky E, Ford HL, Kramerov D, Reshetnyak E, Grigorian M, Zain S, Lukanidin E: Transcriptional analysis of the mts1 gene with specific reference to 5' flanking sequences. Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):9146-50. [Article]
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  7. Tomida Y, Terasawa M, Kobayashi R, Hidaka H: Calcyclin and calvasculin exist in human platelets. Biochem Biophys Res Commun. 1992 Dec 30;189(3):1310-6. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00831Trifluoperazineapproved, investigationalunknowninhibitorDetails
DB09130Copperapproved, investigationalunknownDetails