Genome polyprotein
Details
- Name
- Genome polyprotein
- Synonyms
- 3.4.22.-
- p23
- Gene Name
- Not Available
- Organism
- HCV
- Amino acid sequence
>lcl|BSEQ0010867|Genome polyprotein MSTNPKPQRKTKRNTNRRPQDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRG RRQPIPKARRPEGRTWAQPGYPWPLYGNEGMGWAGWLLSPRGSRPSWGPTDPRRRSRNLG KVIDTLTCGFADLMGYIPLVGAPLGGAARALAHGVRVLEDGVNYATGNLPGCSFSIFLLA LLSCLTIPASAYEVRNVSGIYHVTNDCSNSSIVYEAADMIMHTPGCVPCVRESNFSRCWV ALTPTLAARNSSIPTTTIRRHVDLLVGAAALCSAMYVGDLCGSVFLVSQLFTFSPRRYET VQDCNCSIYPGHVSGHRMAWDMMMNWSPTTALVVSQLLRIPQAVVDMVAGAHWGVLAGLA YYSMVGNWAKVLIVMLLFAGVDGHTHVTGGRVASSTQSLVSWLSQGPSQKIQLVNTNGSW HINRTALNCNDSLQTGFIAALFYAHRFNASGCPERMASCRPIDEFAQGWGPITHDMPESS DQRPYCWHYAPRPCGIVPASQVCGPVYCFTPSPVVVGTTDRFGAPTYSWGENETDVLLLS NTRPPQGNWFGCTWMNSTGFTKTCGGPPCNIGGVGNNTLVCPTDCFRKHPEATYTKCGSG PWLTPRCMVDYPYRLWHYPCTVNFTVFKVRMYVGGVEHRLNAACNWTRGERCDLEDRDRS ELSPLLLSTTEWQILPCSFTTLPALSTGLIHLHRNIVDVQYLYGIGSAVVSFAIKWEYIL LLFLLLADARVCACLWMMLLIAQAEATLENLVVLNAASVAGAHGLLSFLVFFCAAWYIKG RLVPGAAYALYGVWPLLLLLLALPPRAYAMDREMAASCGGAVFVGLVLLTLSPYYKVFLA RLIWWLQYFITRAEAHLQVWVPPLNVRGGRDAIILLTCAVHPELIFDITKLLLAILGPLM VLQAGITRVPYFVRAQGLIRACMLVRKVAGGHYVQMAFMKLAALTGTYVYDHLTPLRDWA HAGLRDLAVAVEPVVFSDMETKLITWGADTAACGDIISGLPVSARRGKEILLGPADSFGE QGWRLLAPITAYSQQTRGLLGCIITSLTGRDKNQVDGEVQVLSTATQSFLATCVNGVCWT VYHGAGSKTLAGPKGPITQMYTNVDQDLVGWPAPPGARSMTPCTCGSSDLYLVTRHADVV PVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPSGHVVGIFRAAVCTRGVAKAVDFIPVES METTMRSPVFTDNSSPPAVPQTFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAA TLGFGAYMSKAHGIEPNIRTGVRTITTGGPITYSTYCKFLADGGCSGGAYDIIICDECHS TDSTTILGIGTVLDQAETAGARLVVLATATPPGSITVPHPNIEEVALSNTGEIPFYGKAI PIEAIKGGRHLIFCHSKKKCDELAAKLTGLGLNAVAYYRGLDVSVIPTSGDVVVVATDAL MTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRAQRRGRTGRGRSGIYR FVTPGERPSGMFDSSVLCECYDAGCAWYELTPAETSVRLRAYLNTPGLPVCQDHLEFWES VFTGLTHIDAHFLSQTKQAGDNLPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHG PTPLLYRLGAVQNEVTLTHPITKYIMACMSADLEVVTSTWVLVGGVLAALAAYCLTTGSV VIVGRIILSGRPAVIPDREVLYQEFDEMEECASHLPYIEQGMQLAEQFKQKALGLLQTAT KQAEAAAPVVESKWRALEVFWAKHMWNFISGIQYLAGLSTLPGNPAIASLMAFTASITSP LTTQNTLLFNILGGWVAAQLAPPSAASAFVGAGIAGAAVGSIGLGKVLVDILAGYGAGVA GALVAFKVMSGEMPSTEDLVNLLPAILSPGALVVGVVCAAILRRHVGPGEGAVQWMNRLI AFASRGNHVSPTHYVPESDAAARVTQILSSLTITQLLKRLHQWINEDCSTPCSGSWLKDV WDWICTVLSDFKTWLQSKLLPRLPGLPFLSCQRGYKGVWRGDGIMQTTCPCGAQITGHVK NGSMRIVGPKTCSNTWHGTFPINAYTTGPCTPSPAPNYSRALWRVAAEEYVEVTRVGDFH YVTGMTTDNVKCPCQVPAPEFFTEVDGVRLHRYAPVCKPLLREEVVFQVGLNQYLVGSQL PCEPEPDVAVLTSMLTDPSHITAETAKRRLARGSPPSLASSSASQLSAPSLKATCTTHHD SPDADLIEANLLWRQEMGGNITRVESENKVVILDSFDPIRAVEDEREISVPAEILRKPRK FPPALPIWARPDYNPPLLESWKDPDYVPPVVHGCPLPSTKAPPIPPPRRKRTVVLTESTV SSALAELATKTFGSSGSSAVDSGTATGPPDQASDDGDKGSDVESYSSMPPLEGEPGDPDL SDGSWSTVSGEAGEDVVCCSMSYTWTGALITPCAAEESKLPINPLSNSLLRHHSMVYSTT SRSASLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKARLLSIEEACKLTPPHSAKSKF GYGAKDVRSLSSRAVNHIRSVWEDLLEDTETPIDTTIMAKNEVFCVQPEKGGRKPARLIV FPDLGVRVCEKMALYDVVSTLPQAVMGPSYGFQYSPGQRVEFLVNTWKSKKCPMGFSYDT RCFDSTVTENDIRTEESIYQCCDLAPEARQAIRSLTERLYVGGPLTNSKGQNCGYRRCRA SGVLTTSCGNTLTCYLKATAACRAAKLQDCTMLVNGDDLVVICESAGTQEDAAALRAFTE AMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETVR HTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQ IIERLHGLSAFSLHSYSPGEINRVASCLRKLGVPPLRVWRHRARSVRAKLLSQGGRAATC GKYLFNWAVKTKLKLTPIPAASQLDLSGWFVAGYNGGDIYHSLSRARPRWFMLCLLLLSV GVGIYLLPNR
- Number of residues
- 3010
- Molecular Weight
- 327018.235
- Theoretical pI
- 8.07
- GO Classification
- FunctionsATP binding / ATP-dependent helicase activity / cysteine-type endopeptidase activity / ion channel activity / RNA binding / RNA helicase activity / RNA-directed RNA polymerase activity / serine-type endopeptidase activity / structural molecule activity / zinc ion bindingProcessesapoptotic process / clathrin-mediated endocytosis of virus by host cell / fusion of virus membrane with host endosome membrane / induction by virus of host autophagy / modulation by virus of host G1/S transition checkpoint / negative regulation of apoptotic process / negative regulation of cell cycle G1/S phase transition / pore formation by virus in membrane of host cell / positive regulation of apoptotic process by virus / protein oligomerization / regulation of transcription, DNA-templated / suppression by virus of host MAVS activity / suppression by virus of host STAT1 activity / suppression by virus of host TRAF activity / suppression by virus of host type I interferon-mediated signaling pathway / transcription, DNA-templated / transformation of host cell by virus / viral RNA genome replication / virion attachment to host cellComponentsextracellular region / host cell cytoplasm / host cell cytosol / host cell endoplasmic reticulum membrane / host cell lipid particle / host cell mitochondrial membrane / host cell nucleus / host cell perinuclear region of cytoplasm / host cell plasma membrane / integral component of membrane / integral to membrane of host cell / viral envelope / viral nucleocapsid / virion membrane
- General Function
- Zinc ion binding
- Specific Function
- Core protein packages viral RNA to form a viral nucleocapsid, and promotes virion budding. Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit. Also regulates many host cellular functions such as signaling pathways and apoptosis. Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation. Thought to play a role in virus-mediated cell transformation leading to hepatocellular carcinomas. Interacts with, and activates STAT3 leading to cellular transformation. May repress the promoter of p53, and sequester CREB3 and SP110 isoform 3/Sp110b in the cytoplasm. Also represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation. Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NK-kappaB activation, and activates AP-1. Could mediate apoptotic pathways through association with TNF-type receptors TNFRSF1A and LTBR, although its effect on death receptor-induced apoptosis remains controversial. Enhances TRAIL mediated apoptosis, suggesting that it might play a role in immune-mediated liver cell injury. Seric core protein is able to bind C1QR1 at the T-cell surface, resulting in down-regulation of T-lymphocytes proliferation. May transactivate human MYC, Rous sarcoma virus LTR, and SV40 promoters. May suppress the human FOS and HIV-1 LTR activity. Alters lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage. Core protein induces up-regulation of FAS promoter activity, and thereby probably contributes to the increased triglyceride accumulation in hepatocytes (steatosis) (By similarity).E1 and E2 glycoproteins form a heterodimer that is involved in virus attachment to the host cell, virion internalization through clathrin-dependent endocytosis and fusion with host membrane. E1/E2 heterodimer binds to human LDLR, CD81 and SCARB1/SR-BI receptors, but this binding is not sufficient for infection, some additional liver specific cofactors may be needed. The fusion function may possibly be carried by E1. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells. DCs act as sentinels in various tissues where they entrap pathogens and convey them to local lymphoid tissue or lymph node for establishment of immunity. Capture of circulating HCV particles by these SIGN+ cells may facilitate virus infection of proximal hepatocytes and lymphocyte subpopulations and may be essential for the establishment of persistent infection (By similarity).P7 seems to be a heptameric ion channel protein (viroporin) and is inhibited by the antiviral drug amantadine. Also inhibited by long-alkyl-chain iminosugar derivatives. Essential for infectivity (By similarity).Protease NS2-3 is a cysteine protease responsible for the autocatalytic cleavage of NS2-NS3. Seems to undergo self-inactivation following maturation (By similarity).NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS3/NS4A complex also prevents phosphorylation of human IRF3, thus preventing the establishment of dsRNA induced antiviral state. NS3 RNA helicase binds to RNA and unwinds dsRNA in the 3' to 5' direction and likely RNA stable secondary structure in the template strand. Cleaves and inhibits the host antiviral protein MAVS (By similarity).NS4B induces a specific membrane alteration that serves as a scaffold for the virus replication complex. This membrane alteration gives rise to the so-called ER-derived membranous web that contains the replication complex.NS5A is a component of the replication complex involved in RNA-binding. Its interaction with Human VAPB may target the viral replication complex to vesicles. Down-regulates viral IRES translation initiation. Mediates interferon resistance, presumably by interacting with and inhibiting human EIF2AK2/PKR. Seems to inhibit apoptosis by interacting with BIN1 and FKBP8. The hyperphosphorylated form of NS5A is an inhibitor of viral replication.NS5B is an RNA-dependent RNA polymerase that plays an essential role in the virus replication.
- Pfam Domain Function
- Transmembrane Regions
- 169-189 359-379 726-746 758-778 783-803 814-834 882-902 929-949 1658-1678 1806-1826 1829-1849 1851-1871 1882-1902 2990-3010
- Cellular Location
- Host endoplasmic reticulum membrane
- Gene sequence
>lcl|BSEQ0002478|9033 bp ATGAGCACAAATCCTAAACCTCAAAGAAAAACCAAACGTAACACCAACCGCCGCCCACAG GACGTTAAGTTCCCGGGCGGTGGTCAGATCGTTGGTGGAGTTTACCTGTTGCCGCGCAGG GGCCCCAGGTTGGGTGTGCGCGCGACTAGGAAGACTTCCGAGCGGTCGCAACCTCGTGGA AGGCGACAACCTATCCCCAAGGCTCGCCGGCCCGAGGGTAGGACCTGGGCTCAGCCCGGG TACCCTTGGCCCCTCTATGGCAACGAGGGTATGGGGTGGGCAGGATGGCTCCTGTCACCC CGTGGCTCTCGGCCTAGTTGGGGCCCCACAGACCCCCGGCGTAGGTCGCGTAATTTGGGT AAGGTCATCGATACCCTTACATGCGGCTTCGCCGACCTCATGGGGTACATTCCGCTTGTC GGCGCCCCCCTAGGGGGCGCTGCCAGGGCCCTGGCACATGGTGTCCGGGTTCTGGAGGAC GGCGTGAACTATGCAACAGGGAATCTGCCCGGTTGCTCTTTCTCTATCTTCCTCTTAGCT TTGCTGTCTTGTTTGACCATCCCAGCTTCCGCTTACGAGGTGCGCAACGTGTCCGGGATA TACCATGTCACGAACGACTGCTCCAACTCAAGTATTGTGTATGAGGCAGCGGACATGATC ATGCACACCCCCGGGTGCGTGCCCTGCGTCCGGGAGAGTAATTTCTCCCGTTGCTGGGTA GCGCTCACTCCCACGCTCGCGGCCAGGAACAGCAGCATCCCCACCACGACAATACGACGC CACGTCGATTTGCTCGTTGGGGCGGCTGCTCTCTGTTCCGCTATGTACGTTGGGGATCTC TGCGGATCCGTTTTTCTCGTCTCCCAGCTGTTCACCTTCTCACCTCGCCGGTATGAGACG GTACAAGATTGCAATTGCTCAATCTATCCCGGCCACGTATCAGGTCACCGCATGGCTTGG GATATGATGATGAACTGGTCACCTACAACGGCCCTAGTGGTATCGCAGCTACTCCGGATC CCACAAGCCGTCGTGGACATGGTGGCGGGGGCCCACTGGGGTGTCCTAGCGGGCCTTGCC TACTATTCCATGGTGGGGAACTGGGCTAAGGTCTTGATTGTGATGCTACTCTTTGCTGGC GTTGACGGGCACACCCACGTGACAGGGGGAAGGGTAGCCTCCAGCACCCAGAGCCTCGTG TCCTGGCTCTCACAAGGCCCATCTCAGAAAATCCAACTCGTGAACACCAACGGCAGCTGG CACATCAACAGGACCGCTCTGAATTGCAATGACTCCCTCCAAACTGGGTTCATTGCTGCG CTGTTCTACGCACACAGGTTCAACGCGTCCGGGTGCCCAGAGCGCATGGCTAGCTGCCGC CCCATCGATGAGTTCGCTCAGGGGTGGGGTCCCATCACTCATGATATGCCTGAGAGCTCG GACCAGAGGCCATATTGCTGGCACTACGCGCCTCGACCGTGCGGGATCGTGCCTGCGTCG CAGGTGTGTGGTCCAGTGTATTGCTTCACTCCGAGCCCTGTTGTAGTGGGGACGACCGAT CGTTTCGGCGCTCCTACGTATAGCTGGGGGGAGAATGAGACAGACGTGCTGCTACTTAGC AACACGCGGCCGCCTCAAGGCAACTGGTTTGGGTGCACGTGGATGAACAGCACTGGGTTC ACCAAGACGTGCGGGGGCCCTCCGTGCAACATCGGGGGGGTCGGCAACAACACCTTGGTC TGCCCCACGGATTGCTTCCGGAAGCACCCCGAGGCCACTTACACAAAGTGTGGCTCGGGG CCCTGGTTGACACCCAGGTGCATGGTTGACTACCCATACAGGCTCTGGCACTACCCCTGC ACTGTTAACTTTACCGTCTTTAAGGTCAGGATGTATGTGGGGGGCGTGGAGCACAGGCTC AATGCTGCATGCAATTGGACTCGAGGAGAGCGCTGTGACTTGGAGGACAGGGATAGGTCA GAACTCAGCCCGCTGCTGCTGTCTACAACAGAGTGGCAGATACTGCCCTGTTCCTTCACC ACCCTACCGGCCCTGTCCACTGGCTTGATCCATCTTCACCGGAACATCGTGGACGTGCAA TACCTGTACGGTATAGGGTCGGCAGTTGTCTCCTTTGCAATCAAATGGGAGTATATCCTG TTGCTTTTCCTTCTTCTGGCGGACGCGCGCGTCTGTGCCTGCTTGTGGATGATGCTGCTG ATAGCCCAGGCTGAGGCCACCTTAGAGAACCTGGTGGTCCTCAATGCGGCGTCTGTGGCC GGAGCGCATGGCCTTCTCTCCTTCCTCGTGTTCTTCTGCGCCGCCTGGTACATCAAAGGC AGGCTGGTCCCTGGGGCGGCATATGCTCTCTATGGCGTATGGCCGTTGCTCCTGCTCTTG CTGGCCTTACCACCACGAGCTTATGCCATGGACCGAGAGATGGCTGCATCGTGCGGAGGC GCGGTTTTTGTAGGTCTGGTACTCTTGACCTTGTCACCATACTATAAGGTGTTCCTCGCT AGGCTCATATGGTGGTTACAATATTTTATCACCAGAGCCGAGGCGCACTTGCAAGTGTGG GTCCCCCCTCTCAATGTTCGGGGAGGCCGCGATGCCATCATCCTCCTTACATGCGCGGTC CATCCAGAGCTAATCTTTGACATCACCAAACTCCTGCTCGCCATACTCGGTCCGCTCATG GTGCTCCAGGCTGGCATAACTAGAGTGCCGTACTTTGTACGCGCTCAGGGGCTCATCCGT GCATGCATGTTAGTGCGGAAGGTCGCTGGAGGCCACTATGTCCAAATGGCCTTCATGAAG CTGGCCGCGCTGACAGGTACGTACGTATATGACCATCTTACTCCACTGCGGGATTGGGCC CACGCGGGCCTACGAGACCTTGCGGTGGCAGTAGAGCCCGTCGTCTTCTCTGACATGGAG ACTAAACTCATCACCTGGGGGGCAGACACCGCGGCGTGTGGGGACATCATCTCGGGTCTA CCAGTCTCCGCCCGAAGGGGGAAGGAGATACTTCTAGGACCGGCCGATAGTTTTGGAGAG CAGGGGTGGCGGCTCCTTGCGCCTATCACGGCCTATTCCCAACAAACGCGGGGCCTGCTT GGCTGTATCATCACTAGCCTCACAGGTCGGGACAAGAACCAGGTCGATGGGGAGGTTCAG GTGCTCTCCACCGCAACGCAATCTTTCCTGGCGACCTGCGTCAATGGCGTGTGTTGGACC GTCTACCATGGTGCCGGCTCGAAGACCCTGGCCGGCCCGAAGGGTCCAATCACCCAAATG TACACCAATGTAGACCAGGACCTCGTCGGCTGGCCGGCGCCCCCCGGGGCGCGCTCCATG ACACCGTGCACCTGCGGCAGCTCGGACCTTTACTTGGTCACGAGGCATGCTGATGTCGTT CCGGTGCGCCGGCGGGGCGACAGCAGGGGGAGCCTGCTTTCCCCCAGGCCCATCTCCTAC CTGAAGGGCTCCTCGGGTGGACCACTGCTTTGCCCTTCGGGGCACGTTGTAGGCATCTTC CGGGCTGCTGTGTGCACCCGGGGGGTTGCGAAGGCGGTGGACTTCATACCCGTTGAGTCT ATGGAAACTACCATGCGGTCTCCGGTCTTCACAGACAACTCATCCCCTCCGGCCGTACCG CAAACATTCCAAGTGGCACATTTACACGCTCCCACTGGCAGCGGCAAGAGCACCAAAGTG CCGGCTGCATATGCAGCCCAAGGGTACAAGGTGCTCGTCCTAAACCCGTCCGTTGCCGCC ACATTGGGCTTTGGAGCGTATATGTCCAAGGCACATGGCATCGAGCCTAACATCAGAACT GGGGTAAGGACCATCACCACGGGCGGCCCCATCACGTACTCCACCTATTGCAAGTTCCTT GCCGACGGTGGATGCTCCGGGGGCGCCTATGACATCATAATATGTGATGAATGCCACTCA ACTGACTCGACTACCATCTTGGGCATCGGCACAGTCCTGGATCAGGCAGAGACGGCTGGA GCGCGGCTCGTCGTGCTCGCCACCGCCACGCCTCCGGGATCGATCACCGTGCCACACCCC AACATCGAGGAAGTGGCCCTGTCCAACACTGGAGAGATTCCCTTCTATGGCAAAGCCATC CCCATTGAGGCCATCAAGGGGGGAAGGCATCTCATCTTCTGCCATTCCAAGAAGAAGTGT GACGAGCTCGCCGCAAAGCTGACAGGCCTCGGACTCAATGCTGTAGCGTATTACCGGGGT CTCGATGTGTCCGTCATACCGACTAGCGGAGACGTCGTTGTCGTGGCAACAGACGCTCTA ATGACGGGTTTTACCGGCGACTTTGACTCAGTGATCGACTGCAACACATGTGTCACCCAG ACAGTCGATTTCAGCTTGGATCCCACCTTCACCATTGAGACGACAACGCTGCCCCAAGAC GCGGTGTCGCGTGCGCAGCGGCGAGGTAGGACTGGCAGGGGCAGGAGTGGCATCTACAGG TTTGTGACTCCAGGAGAACGGCCCTCAGGCATGTTCGACTCCTCGGTCCTGTGTGAGTGC TATGACGCAGGCTGCGCTTGGTATGAGCTCACGCCCGCTGAGACCTCGGTTAGGTTGCGG GCTTACCTAAATACACCAGGGTTGCCCGTCTGCCAGGACCACCTAGAGTTCTGGGAGAGC GTCTTCACAGGCCTCACCCACATAGATGCCCACTTCTTGTCCCAGACCAAACAGGCAGGA GACAACCTCCCCTACCTGGTAGCATACCAAGCCACAGTGTGCGCCAGGGCTCAGGCTCCA CCTCCATCGTGGGACCAAATGTGGAAGTGTCTCATACGGCTAAAGCCCACACTGCATGGG CCAACGCCCCTGCTGTACAGGCTAGGAGCCGTTCAAAATGAGGTCACTCTCACACACCCC ATAACCAAATACATCATGGCATGCATGTCGGCTGACCTGGAGGTCGTCACTAGCACCTGG GTGCTAGTAGGCGGAGTCCTTGCGGCTCTGGCCGCGTACTGCCTGACGACAGGCAGCGTG GTCATTGTGGGCAGGATCATCTTGTCCGGGAGGCCAGCTGTTATTCCCGACAGGGAAGTC CTCTACCAGGAGTTCGATGAGATGGAAGAGTGTGCTTCACACCTCCCTTACATCGAGCAA GGAATGCAGCTCGCCGAGCAATTCAAACAGAAGGCGCTCGGATTGCTGCAAACAGCCACC AAGCAAGCGGAGGCTGCTGCTCCCGTGGTGGAGTCCAAGTGGCGAGCCCTTGAGGTCTTC TGGGCGAAACACATGTGGAACTTCATCAGCGGGATACAGTACTTGGCAGGCCTATCCACT CTGCCTGGAAACCCCGCGATAGCATCATTGATGGCTTTTACAGCCTCTATCACCAGCCCG CTCACCACCCAAAATACCCTCCTGTTTAACATCTTGGGGGGATGGGTGGCTGCCCAACTC GCTCCCCCCAGCGCTGCTTCGGCTTTCGTGGGCGCCGGCATTGCCGGTGCGGCCGTTGGC AGCATAGGTCTCGGGAAGGTACTTGTGGACATTCTGGCGGGCTATGGGGCGGGGGTGGCT GGCGCACTCGTGGCCTTTAAGGTCATGAGCGGCGAGATGCCCTCCACTGAGGATCTGGTT AATTTACTCCCTGCCATCCTTTCTCCTGGCGCCCTGGTTGTCGGGGTCGTGTGCGCAGCA ATACTGCGTCGGCACGTGGGCCCGGGAGAGGGGGCTGTGCAGTGGATGAACCGGCTGATA GCGTTCGCTTCGCGGGGTAACCACGTCTCCCCCACGCACTATGTGCCCGAGAGCGACGCC GCGGCGCGTGTTACTCAGATCCTCTCCAGCCTTACCATCACTCAGTTGCTGAAGAGGCTT CATCAGTGGATTAATGAGGACTGCTCCACGCCTTGTTCCGGCTCGTGGCTAAAGGATGTT TGGGACTGGATATGCACGGTGTTGAGTGACTTCAAGACTTGGCTCCAGTCCAAGCTCCTG CCGCGGTTACCGGGACTCCCTTTCCTGTCATGCCAACGCGGGTACAAGGGAGTCTGGCGG GGGGATGGCATCATGCAAACCACCTGCCCATGTGGAGCACAGATCACCGGACATGTCAAA AATGGCTCCATGAGGATTGTTGGGCCAAAAACCTGCAGCAACACGTGGCATGGAACATTC CCCATCAACGCATACACCACGGGCCCCTGCACGCCCTCCCCAGCGCCGAACTATTCCAGG GCGCTGTGGCGGGTGGCTGCTGAGGAGTACGTGGAGGTTACGCGGGTGGGGGATTTCCAC TACGTGACGGGCATGACCACTGACAACGTGAAATGCCCATGCCAGGTTCCAGCCCCTGAA TTTTTCACGGAGGTGGATGGAGTACGGTTGCACAGGTATGCTCCAGTGTGCAAACCTCTC CTACGAGAGGAGGTCGTATTCCAGGTCGGGCTCAACCAGTACCTGGTCGGGTCACAGCTC CCATGTGAGCCCGAACCGGATGTGGCAGTGCTCACTTCCATGCTCACCGACCCCTCTCAT ATTACAGCAGAGACGGCCAAGCGTAGGCTGGCCAGGGGGTCTCCCCCCTCCTTGGCCAGC TCTTCAGCTAGCCAGTTGTCTGCGCCTTCTTTGAAGGCGACATGTACTACCCATCATGAC TCCCCGGACGCTGACCTCATCGAGGCCAACCTCCTGTGGCGGCAGGAGATGGGCGGGAAC ATCACCCGTGTGGAGTCAGAAAATAAGGTGGTAATCCTGGACTCTTTCGATCCGATTCGG GCGGTGGAGGATGAGAGGGAAATATCCGTCCCGGCGGAGATCCTGCGAAAACCCAGGAAG TTCCCCCCAGCGTTGCCCATATGGGCACGCCCGGATTACAACCCTCCACTGCTAGAGTCC TGGAAGGACCCGGACTACGTCCCCCCGGTGGTACACGGGTGCCCTTTGCCATCTACCAAG GCCCCCCCAATACCACCTCCACGGAGGAAGAGGACGGTTGTCCTGACAGAGTCCACCGTG TCTTCTGCCTTGGCGGAGCTCGCTACTAAGACCTTTGGCAGCTCCGGGTCGTCGGCCGTT GACAGCGGCACGGCGACTGGCCCTCCCGATCAGGCCTCCGACGACGGCGACAAAGGATCC GACGTTGAGTCGTACTCCTCCATGCCCCCCCTCGAGGGAGAGCCAGGGGACCCCGACCTC AGCGACGGGTCTTGGTCTACCGTGAGCGGGGAAGCTGGTGAGGACGTCGTCTGCTGCTCA ATGTCCTATACATGGACAGGTGCCTTGATCACGCCATGCGCTGCGGAGGAGAGCAAGTTG CCCATCAATCCGTTGAGCAACTCTTTGCTGCGTCACCACAGTATGGTCTACTCCACAACA TCTCGCAGCGCAAGTCTGCGGCAGAAGAAGGTCACCTTTGACAGACTGCAAGTCCTGGAC GACCACTACCGGGACGTGCTCAAGGAGATGAAGGCGAAGGCGTCCACAGTTAAGGCTAGG CTTCTATCTATAGAGGAGGCCTGCAAACTGACGCCCCCACATTCGGCCAAATCCAAATTT GGCTACGGGGCGAAGGACGTCCGGAGCCTATCCAGCAGGGCCGTCAACCACATCCGCTCC GTGTGGGAGGACTTGCTGGAAGACACTGAAACACCAATTGATACCACCATCATGGCAAAA AATGAGGTTTTCTGCGTCCAACCAGAGAAAGGAGGCCGCAAGCCAGCTCGCCTTATCGTA TTCCCAGACCTGGGGGTACGTGTATGCGAGAAGATGGCCCTTTACGACGTGGTCTCCACC CTTCCTCAGGCCGTGATGGGCCCCTCATACGGATTCCAGTACTCTCCTGGGCAGCGGGTC GAGTTCCTGGTGAATACCTGGAAATCAAAGAAATGCCCTATGGGCTTCTCATATGACACC CGCTGCTTTGACTCAACGGTCACTGAGAATGACATCCGTACTGAGGAATCAATTTACCAA TGTTGTGACTTGGCCCCCGAAGCCAGGCAGGCCATAAGGTCGCTCACAGAGCGGCTTTAT GTCGGGGGTCCCCTGACTAATTCGAAGGGGCAGAACTGCGGTTATCGCCGGTGCCGCGCA AGTGGCGTGCTGACGACTAGCTGCGGCAACACCCTCACATGTTACTTGAAGGCCACTGCG GCCTGTCGAGCTGCAAAGCTCCAGGACTGCACGATGCTCGTGAACGGAGACGACCTTGTC GTTATCTGTGAGAGTGCGGGAACCCAGGAGGATGCGGCGGCCCTACGAGCCTTCACGGAG GCTATGACTAGGTATTCCGCCCCCCCCGGGGACCCGCCCCAACCAGAATACGACTTGGAG CTGATAACGTCATGCTCCTCCAATGTGTCGGTCGCGCACGATGCATCCGGCAAAAGGGTG TACTACCTCACCCGTGACCCCACCACCCCCCTCGCACGGGCTGCGTGGGAGACAGTTAGA CACACTCCAGTCAACTCCTGGCTAGGCAATATCATCATGTATGCGCCCACCCTATGGGCG AGGATGATTCTGATGACTCATTTCTTCTCTATCCTTCTAGCTCAGGAGCAACTTGAAAAA GCCCTGGATTGTCAGATCTACGGGGCCTGTTACTCCATTGAGCCACTTGACCTACCTCAG ATCATTGAACGACTCCATGGTCTTAGCGCATTTTCACTCCACAGTTACTCTCCAGGTGAG ATCAATAGGGTGGCTTCATGCCTCAGGAAACTTGGGGTACCGCCTTTGCGAGTCTGGAGA CATCGGGCCAGAAGTGTCCGCGCTAAGCTACTGTCCCAGGGGGGGAGGGCTGCCACTTGC GGCAAGTACCTCTTCAACTGGGCAGTAAAGACCAAGCTTAAACTCACTCCAATCCCGGCT GCGTCCCAGCTAGACTTGTCCGGCTGGTTCGTTGCTGGTTACAACGGGGGAGACATATAT CACAGCCTGTCTCGTGCCCGACCCCGTTGGTTCATGTTGTGCCTACTCCTACTTTCTGTA GGGGTAGGCATCTACCTGCTCCCCAACCGGTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P26662 UniProtKB Entry Name POLG_HCVJA GenBank Protein ID 221611 GenBank Gene ID D90208 - General References
- Kato N, Hijikata M, Ootsuyama Y, Nakagawa M, Ohkoshi S, Sugimura T, Shimotohno K: Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis. Proc Natl Acad Sci U S A. 1990 Dec;87(24):9524-8. [Article]
- Kato N, Hijikata M, Nakagawa M, Ootsuyama Y, Muraiso K, Ohkoshi S, Shimotohno K: Molecular structure of the Japanese hepatitis C viral genome. FEBS Lett. 1991 Mar 25;280(2):325-8. [Article]
- Hijikata M, Mizushima H, Akagi T, Mori S, Kakiuchi N, Kato N, Tanaka T, Kimura K, Shimotohno K: Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus. J Virol. 1993 Aug;67(8):4665-75. [Article]
- Shih CM, Lo SJ, Miyamura T, Chen SY, Lee YH: Suppression of hepatitis B virus expression and replication by hepatitis C virus core protein in HuH-7 cells. J Virol. 1993 Oct;67(10):5823-32. [Article]
- Bartenschlager R, Ahlborn-Laake L, Mous J, Jacobsen H: Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions. J Virol. 1993 Jul;67(7):3835-44. [Article]
- Kaneko T, Tanji Y, Satoh S, Hijikata M, Asabe S, Kimura K, Shimotohno K: Production of two phosphoproteins from the NS5A region of the hepatitis C viral genome. Biochem Biophys Res Commun. 1994 Nov 30;205(1):320-6. [Article]
- Tanji Y, Kaneko T, Satoh S, Shimotohno K: Phosphorylation of hepatitis C virus-encoded nonstructural protein NS5A. J Virol. 1995 Jul;69(7):3980-6. [Article]
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