Adenylate kinase

Details

Name

Adenylate kinase

Synonyms

• 2.7.4.3
• Adenylate monophosphate kinase
• AK
• ATP-AMP transphosphorylase
• ATP:AMP phosphotransferase

Gene Name

adk

Organism

Geobacillus stearothermophilus

Amino acid sequence

>lcl|BSEQ0016368|Adenylate kinase
MNLVLMGLPGAGKGTQAEKIVAAYGIPHISTGDMFRAAMKEGTPLGLQAKQYMDRGDLVP
DEVTIGIVRERLSKDDCQNGFLLDGFPRTVAQAEALETMLADIGRKLDYVIHIDVRQDVL
MERLTGRRICRNCGATYHLIFHPPAKPGVCDKCGGELYQRADDNEATVANRLEVNMKQMK
PLVDFYEQKGYLRNINGEQDMEKVFADIRELLGGLAR

Number of residues

217

Molecular Weight

24142.65

Theoretical pI

6.13

GO Classification

Functions

adenylate kinase activity / ATP binding / metal ion binding

Processes

AMP salvage

Components

cytoplasm

General Function

Metal ion binding

Specific Function

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.

Pfam Domain Function

• ADK_lid (PF05191)

Transmembrane Regions

Not Available

Cellular Location

Cytoplasm

Gene sequence

>lcl|BSEQ0002496|654 bp
ATGAATTTAGTGCTGATGGGGCTGCCGGGTGCCGGCAAAGGCACGCAGGCCGAGAAAATC
GTAGCGGCTTACGGTATTCCGCACATTTCAACGGGCGATATGTTTCGGGCGGCGATGAAG
GAAGGAACGCCGCTAGGGCTTCAAGCGAAGCAATATATGGACCGCGGCGACCTTGTTCCG
GATGAAGTGACGATCGGCATTGTCCGTGAACGGCTGAGCAAAGACGATTGCCAAAACGGT
TTTTTGCTCGATGGATTCCCGCGCACGGTCGCTCAAGCGGAGGCGCTGGAAACGATGTTG
GCCGACATTGGCCGCAAACTTGACTATGTCATCCATATCGATGTCCGCCAAGACGTTTTA
ATGGAGCGCTTGACCGGCAGACGGATTTGCCGCAACTGCGGAGCGACGTACCATCTTATT
TTTCATCCGCCGGCGAAACCGGGTGTTTGCGATAAGTGCGGGGGGGAATTGTACCAGCGC
GCCGATGATAACGAAGCGACAGTGGCGAACCGGCTCGAAGTGAATATGAAACAAATGAAG
CCGCTCGTTGACTTTTACGAACAAAAAGGCTATTTGCGCAACATTAACGGCGAACAGGAC
ATGGAAAAGGTGTTTGCCGATATTCGTGAATTGCTCGGGGGACTTGCTCGATGA

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	P27142
UniProtKB Entry Name	KAD_GEOSE
GenBank Protein ID	142446
GenBank Gene ID	M88104

General References

1. Glaser P, Presecan E, Delepierre M, Surewicz WK, Mantsch HH, Barzu O, Gilles AM: Zinc, a novel structural element found in the family of bacterial adenylate kinases. Biochemistry. 1992 Mar 31;31(12):3038-43. [Article]
2. Berry MB, Phillips GN Jr: Crystal structures of Bacillus stearothermophilus adenylate kinase with bound Ap5A, Mg2+ Ap5A, and Mn2+ Ap5A reveal an intermediate lid position and six coordinate octahedral geometry for bound Mg2+ and Mn2+. Proteins. 1998 Aug 15;32(3):276-88. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB01717	Bis(Adenosine)-5'-Pentaphosphate	experimental	unknown		Details