Pyrroloquinoline-quinone synthase
Details
- Name
- Pyrroloquinoline-quinone synthase
- Synonyms
- 1.3.3.11
- Coenzyme PQQ synthesis protein C
- Pyrroloquinoline quinone biosynthesis protein C
- Gene Name
- pqqC
- Organism
- Klebsiella pneumoniae
- Amino acid sequence
>lcl|BSEQ0012111|Pyrroloquinoline-quinone synthase MLITDTLSPQAFEEALRAKGAFYHIHHPYHIAMHNGDATRKQIQGWVANRFYYQTTIPLK DAAIMANCPDAQTRRKWVQRILDHDGSHGEDGGIEAWLRLGEAVGLSRDDLLSERHVLPG VRFAVDAYLNFARRACWQEAACSSLTELFAPQIHQSRLDSWPQHYPWIKEEGYFYFRSRL SQANRDVEHGLALAKAYCDSAEKQNRMLEILQFKLDILWSMLDAMTMAYALQRPPYHTVT DKAAWHTTRLV
- Number of residues
- 251
- Molecular Weight
- 28985.66
- Theoretical pI
- 7.42
- GO Classification
- Functionspyrroloquinoline-quinone synthase activityProcessespyrroloquinoline quinone biosynthetic process
- General Function
- Pyrroloquinoline-quinone synthase activity
- Specific Function
- Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ.
- Pfam Domain Function
- TENA_THI-4 (PF03070)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0005891|756 bp ATGCTGATCACTGACACGCTGTCGCCGCAGGCCTTTGAAGAGGCTCTGCGGGCTAAAGGC GCCTTCTACCATATTCACCACCCTTACCACATCGCCATGCATAACGGCGACGCGACCCGC AAGCAAATTCAGGGTTGGGTGGCGAACCGGTTTTATTACCAGACCACTATTCCGCTGAAA GACGCGGCGATTATGGCCAACTGCCCGGATGCGCAGACCCGGCGCAAATGGGTGCAGCGG ATCCTCGACCACGACGGCAGCCACGGCGAGGACGGCGGGATTGAAGCCTGGCTGCGGCTG GGGGAAGCGGTCGGTTTGAGCCGCGACGATCTGCTCAGCGAGCGTCACGTGCTGCCCGGC GTGCGCTTCGCAGTGGATGCCTATCTCAATTTCGCTCGTCGCGCCTGCTGGCAGGAGGCG GCCTGCAGCTCCCTGACCGAGCTGTTCGCCCCGCAGATCCATCAGTCGCGCCTCGACAGC TGGCCGCAGCACTATCCATGGATCAAAGAGGAAGGCTACTTTTACTTCCGCAGTCGTCTG AGCCAGGCTAACCGCGACGTTGAGCATGGTCTGGCGCTGGCGAAGGCCTACTGCGACAGC GCTGAAAAACAGAACCGGATGCTGGAGATCCTGCAGTTTAAGCTCGACATTCTGTGGTCG ATGCTCGATGCCATGACCATGGCCTATGCCCTGCAGCGCCCGCCCTATCACACGGTCACC GACAAGGCGGCCTGGCACACGACCCGACTGGTGTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P27505 UniProtKB Entry Name PQQC_KLEPN GenBank Gene ID X58778 - General References
- Meulenberg JJ, Sellink E, Riegman NH, Postma PW: Nucleotide sequence and structure of the Klebsiella pneumoniae pqq operon. Mol Gen Genet. 1992 Mar;232(2):284-94. [Article]
- Velterop JS, Sellink E, Meulenberg JJ, David S, Bulder I, Postma PW: Synthesis of pyrroloquinoline quinone in vivo and in vitro and detection of an intermediate in the biosynthetic pathway. J Bacteriol. 1995 Sep;177(17):5088-98. [Article]
- Magnusson OT, Toyama H, Saeki M, Rojas A, Reed JC, Liddington RC, Klinman JP, Schwarzenbacher R: Quinone biogenesis: Structure and mechanism of PqqC, the final catalyst in the production of pyrroloquinoline quinone. Proc Natl Acad Sci U S A. 2004 May 25;101(21):7913-8. Epub 2004 May 17. [Article]