Calreticulin

Details

Name
Calreticulin
Synonyms
  • Calregulin
  • CRP55
  • CRTC
  • Endoplasmic reticulum resident protein 60
  • ERp60
  • grp60
  • HACBP
Gene Name
CALR
Organism
Humans
Amino acid sequence
>lcl|BSEQ0011528|Calreticulin
MLLSVPLLLGLLGLAVAEPAVYFKEQFLDGDGWTSRWIESKHKSDFGKFVLSSGKFYGDE
EKDKGLQTSQDARFYALSASFEPFSNKGQTLVVQFTVKHEQNIDCGGGYVKLFPNSLDQT
DMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRCKDDEFTHLYTLIVRPDN
TYEVKIDNSQVESGSLEDDWDFLPPKKIKDPDASKPEDWDERAKIDDPTDSKPEDWDKPE
HIPDPDAKKPEDWDEEMDGEWEPPVIQNPEYKGEWKPRQIDNPDYKGTWIHPEIDNPEYS
PDPSIYAYDNFGVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMKDK
QDEEQRLKEEEEDKKRKEEEEAEDKEDDEDKDEDEEDEEDKEEDEEEDVPGQAKDEL
Number of residues
417
Molecular Weight
48141.2
Theoretical pI
4.04
GO Classification
Functions
androgen receptor binding / calcium ion binding / carbohydrate binding / chaperone binding / complement component C1q binding / DNA binding / glycoprotein binding / hormone binding / integrin binding / iron ion binding / mRNA binding / peptide binding / poly(A) RNA binding / protein binding involved in protein folding / ubiquitin protein ligase binding / unfolded protein binding / zinc ion binding
Processes
antigen processing and presentation of exogenous peptide antigen via MHC class I / antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent / antigen processing and presentation of peptide antigen via MHC class I / ATF6-mediated unfolded protein response / cardiac muscle cell differentiation / cell cycle arrest / cellular calcium ion homeostasis / cellular protein metabolic process / cellular response to lithium ion / cellular senescence / chaperone-mediated protein folding / cortical actin cytoskeleton organization / endoplasmic reticulum unfolded protein response / glucocorticoid receptor signaling pathway / negative regulation of intracellular steroid hormone receptor signaling pathway / negative regulation of neuron differentiation / negative regulation of retinoic acid receptor signaling pathway / negative regulation of transcription from RNA polymerase II promoter / negative regulation of transcription, DNA-templated / negative regulation of translation / peptide antigen assembly with MHC class I protein complex / positive regulation of cell cycle / positive regulation of cell proliferation / positive regulation of dendritic cell chemotaxis / positive regulation of DNA replication / positive regulation of gene expression / positive regulation of phagocytosis / positive regulation of substrate adhesion-dependent cell spreading / post-translational protein modification / protein export from nucleus / protein folding / protein folding in endoplasmic reticulum / protein localization to nucleus / protein maturation by protein folding / protein N-linked glycosylation via asparagine / protein stabilization / receptor-mediated endocytosis / regulation of apoptotic process / regulation of meiotic nuclear division / regulation of transcription, DNA-templated / response to drug / response to estradiol / response to testosterone / sequestering of calcium ion / spermatogenesis
Components
acrosomal vesicle / cell surface / cytoplasm / cytosol / endocytic vesicle lumen / endoplasmic reticulum / endoplasmic reticulum lumen / external side of plasma membrane / extracellular exosome / extracellular region / extracellular space / focal adhesion / Golgi apparatus / integral component of lumenal side of endoplasmic reticulum membrane / intracellular / membrane / MHC class I peptide loading complex / nucleus / perinuclear region of cytoplasm / polysome / proteinaceous extracellular matrix / sarcoplasmic reticulum lumen / smooth endoplasmic reticulum
General Function
Zinc ion binding
Specific Function
Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Endoplasmic reticulum lumen
Gene sequence
>lcl|BSEQ0011529|Calreticulin (CALR)
ATGCTGCTATCCGTGCCGCTGCTGCTCGGCCTCCTCGGCCTGGCCGTCGCCGAGCCTGCC
GTCTACTTCAAGGAGCAGTTTCTGGACGGAGACGGGTGGACTTCCCGCTGGATCGAATCC
AAACACAAGTCAGATTTTGGCAAATTCGTTCTCAGTTCCGGCAAGTTCTACGGTGACGAG
GAGAAAGATAAAGGTTTGCAGACAAGCCAGGATGCACGCTTTTATGCTCTGTCGGCCAGT
TTCGAGCCTTTCAGCAACAAAGGCCAGACGCTGGTGGTGCAGTTCACGGTGAAACATGAG
CAGAACATCGACTGTGGGGGCGGCTATGTGAAGCTGTTTCCTAATAGTTTGGACCAGACA
GACATGCACGGAGACTCAGAATACAACATCATGTTTGGTCCCGACATCTGTGGCCCTGGC
ACCAAGAAGGTTCATGTCATCTTCAACTACAAGGGCAAGAACGTGCTGATCAACAAGGAC
ATCCGTTGCAAGGATGATGAGTTTACACACCTGTACACACTGATTGTGCGGCCAGACAAC
ACCTATGAGGTGAAGATTGACAACAGCCAGGTGGAGTCCGGCTCCTTGGAAGACGATTGG
GACTTCCTGCCACCCAAGAAGATAAAGGATCCTGATGCTTCAAAACCGGAAGACTGGGAT
GAGCGGGCCAAGATCGATGATCCCACAGACTCCAAGCCTGAGGACTGGGACAAGCCCGAG
CATATCCCTGACCCTGATGCTAAGAAGCCCGAGGACTGGGATGAAGAGATGGACGGAGAG
TGGGAACCCCCAGTGATTCAGAACCCTGAGTACAAGGGTGAGTGGAAGCCCCGGCAGATC
GACAACCCAGATTACAAGGGCACTTGGATCCACCCAGAAATTGACAACCCCGAGTATTCT
CCCGATCCCAGTATCTATGCCTATGATAACTTTGGCGTGCTGGGCCTGGACCTCTGGCAG
GTCAAGTCTGGCACCATCTTTGACAACTTCCTCATCACCAACGATGAGGCATACGCTGAG
GAGTTTGGCAACGAGACGTGGGGCGTAACAAAGGCAGCAGAGAAACAAATGAAGGACAAA
CAGGACGAGGAGCAGAGGCTTAAGGAGGAGGAAGAAGACAAGAAACGCAAAGAGGAGGAG
GAGGCAGAGGACAAGGAGGATGATGAGGACAAAGATGAGGATGAGGAGGATGAGGAGGAC
AAGGAGGAAGATGAGGAGGAAGATGTCCCCGGCCAGGCCAAGGACGAGCTGTAG
Chromosome Location
19
Locus
19p13.3-p13.2
External Identifiers
ResourceLink
UniProtKB IDP27797
UniProtKB Entry NameCALR_HUMAN
GenBank Protein ID337487
GenBank Gene IDM32294
GenAtlas IDCALR
HGNC IDHGNC:1455
General References
  1. McCauliffe DP, Lux FA, Lieu TS, Sanz I, Hanke J, Newkirk MM, Bachinski LL, Itoh Y, Siciliano MJ, Reichlin M, et al.: Molecular cloning, expression, and chromosome 19 localization of a human Ro/SS-A autoantigen. J Clin Invest. 1990 May;85(5):1379-91. [Article]
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  9. Rojiani MV, Finlay BB, Gray V, Dedhar S: In vitro interaction of a polypeptide homologous to human Ro/SS-A antigen (calreticulin) with a highly conserved amino acid sequence in the cytoplasmic domain of integrin alpha subunits. Biochemistry. 1991 Oct 15;30(41):9859-66. [Article]
  10. Krause KH, Simmerman HK, Jones LR, Campbell KP: Sequence similarity of calreticulin with a Ca2(+)-binding protein that co-purifies with an Ins(1,4,5)P3-sensitive Ca2+ store in HL-60 cells. Biochem J. 1990 Sep 1;270(2):545-8. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00025Antihemophilic factor, human recombinantapproved, investigationalunknownchaperoneDetails
DB00031TenecteplaseapprovedunknownDetails
DB06245LanoteplaseinvestigationalunknownDetails
DB01065Melatoninapproved, nutraceutical, vet_approvedunknownDetails
DB11093Calcium citrateapproved, investigationalnoligandDetails
DB11348Calcium PhosphateapprovednoligandDetails
DB09130Copperapproved, investigationalunknownDetails
DB13998Lonoctocog alfaapproved, investigationalunknownchaperoneDetails
DB13999Moroctocog alfaapprovedunknownchaperoneDetails
DB13949Ferric cationapprovedunknownbinderDetails
DB14481Calcium phosphate dihydrateapprovednoDetails
DB14520Tetraferric tricitrate decahydrateapprovedunknownbinderDetails