NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Details
- Name
- NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
- Synonyms
- 1.6.5.3
- CI-75kD
- Complex I-75kD
- Gene Name
- NDUFS1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0000984|NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial MLRIPVRKALVGLSKSPKGCVRTTATAASNLIEVFVDGQSVMVEPGTTVLQACEKVGMQI PRFCYHERLSVAGNCRMCLVEIEKAPKVVAACAMPVMKGWNILTNSEKSKKAREGVMEFL LANHPLDCPICDQGGECDLQDQSMMFGNDRSRFLEGKRAVEDKNIGPLVKTIMTRCIQCT RCIRFASEIAGVDDLGTTGRGNDMQVGTYIEKMFMSELSGNIIDICPVGALTSKPYAFTA RPWETRKTESIDVMDAVGSNIVVSTRTGEVMRILPRMHEDINEEWISDKTRFAYDGLKRQ RLTEPMVRNEKGLLTYTSWEDALSRVAGMLQSFQGKDVAAIAGGLVDAEALVALKDLLNR VDSDTLCTEEVFPTAGAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPLFNARIRK SWLHNDLKVALIGSPVDLTYTYDHLGDSPKILQDIASGSHPFSQVLKEAKKPMVVLGSSA LQRNDGAAILAAVSSIAQKIRMTSGVTGDWKVMNILHRIASQVAALDLGYKPGVEAIRKN PPKVLFLLGADGGCITRQDLPKDCFIIYQGHHGDVGAPIADVILPGAAYTEKSATYVNTE GRAQQTKVAVTPPGLAREDWKIIRALSEIAGMTLPYDTLDQVRNRLEEVSPNLVRYDDIE GANYFQQANELSKLVNQQLLADPLVPPQLTIKDFYMTDSISRASQTMAKCVKAVTEGAQA VEEPSIC
- Number of residues
- 727
- Molecular Weight
- 79466.77
- Theoretical pI
- 6.11
- GO Classification
- Functions2 iron, 2 sulfur cluster binding / 4 iron, 4 sulfur cluster binding / electron carrier activity / iron-sulfur cluster binding / metal ion binding / NADH dehydrogenase (ubiquinone) activityProcessesapoptotic mitochondrial changes / ATP metabolic process / cellular metabolic process / cellular respiration / mitochondrial electron transport, NADH to ubiquinone / reactive oxygen species metabolic process / regulation of mitochondrial membrane potential / respiratory electron transport chain / small molecule metabolic processComponentsmitochondrial intermembrane space / mitochondrial matrix / mitochondrial respiratory chain complex I / mitochondrion / myelin sheath
- General Function
- Nadh dehydrogenase (ubiquinone) activity
- Specific Function
- Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Mitochondrion inner membrane
- Gene sequence
>lcl|BSEQ0010346|NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (NDUFS1) ATGTTAAGGATACCTGTAAGAAAGGCCTTAGTAGGCCTTTCTAAGTCTCCTAAAGGATGT GTTCGAACAACTGCCACAGCAGCAAGCAACTTGATTGAAGTATTTGTTGATGGTCAGTCT GTCATGGTGGAACCGGGAACGACCGTCCTCCAAGTTGTAGCTGCTTGTGCCATGCCAGTA ATGAAGGGTTGGAATATCCTAACAAACTCAGAAAAATCCAAAAAAGCCAGGGAAGGTGTG ATGGAGTTCTTATTAGCAAATCACCCATTGGACTGTCCTATTTGTGACCAGGGAGGTGAA TGTGATCTGCAGGACCAGTCCATGATGTTTGGAAATGATAGGAGCCGATTTTTAGAGGGG AAGCGTGCTGTGGAAGACAAGAACATTGGGCCATTGGTAAAGACCATCATGACAAGATGT ATACAGTGTACTCGCTGCATCAGGTTTGCAAGTGAGATTGCAGGAGTAGATGATTTGGGA ACAACAGGCAGAGGAAATGATATGCAAGTTGGCACATACATTGAAAAGATGTTCATGTCT GAACTGTCTGGGAATATCATTGATATCTGCCCTGTAGGTGCCCTAACCTCTAAGCCCTAT GCCTTTACTGCCCGGCCTTGGGAAACAAGAAAGACAGAATCCATTGATGTAATGGATGCG GTTGGAAGTAATATTGTGGTTAGCACAAGAACTGGAGAAGTGATGAGGATTTTGCCACGT ATGCATGAGGACATCAATGAAGAGTGGATCTCTGATAAAACCAGATTTGCCTATGATGGG CTAAAACGTCAAAGACTTACCGAGCCAATGGTCAGAAATGAAAAAGGGCTTTTAACCTAT ACTTCTTGGGAGGATGCGCTCTCTCGCGTAGCTGGAATGTTGCAGAGTTTTCAAGGCAAA GATGTGGCAGCAATTGCAGGTGGCTTGGTGGATGCTGAAGCCCTGGTAGCTCTCAAAGAT TTGCTTAATAGAGTGGACTCTGACACCTTATGCACTGAAGAGGTCTTCCCCACTGCAGGA GCTGGCACAGATTTGCGTTCCAATTATCTTCTTAATACTACAATTGCTGGTGTGGAAGAG GCAGATGTTGTTCTTCTGGTTGGTACAAACCCACGTTTTGAGGCACCACTGTTTAATGCT AGAATTCGAAAGAGCTGGCTGCATAATGACTTAAAAGTGGCCCTTATAGGCAGTCCAGTG GACCTCACTTACACATATGACCACCTGGGAGACTCCCCCAAAATTCTTCAAGACATTGCT TCGGGAAGCCATCCATTTAGCCAGGTCCTAAAGGAAGCTAAAAAACCAATGGTGGTTTTA GGCAGTTCTGCACTCCAAAGAAATGATGGAGCAGCAATTCTTGCAGCTGTTTCTAGCATT GCACAAAAGATTCGGATGACTAGTGGTGTTACTGGTGATTGGAAAGTTATGAATATCCTT CATAGGATTGCAAGTCAAGTAGCTGCTTTGGACCTTGGCTATAAGCCTGGGGTGGAAGCA ATTCGGAAGAACCCTCCCAAGGTGCTGTTTCTCCTGGGAGCAGATGGAGGTTGTATCACA CGACAGGATTTGCCAAAGGATTGTTTCATTATTTATCAAGGACATCATGGTGATGTTGGG GCTCCCATAGCTGATGTTATTCTCCCAGGAGCTGCTTACACAGAGAAGTCTGCTACATAT GTCAACACTGAGGGTAGAGCTCAGCAGACTAAGGTAGCAGTGACACCTCCTGGCTTGGCA AGAGAAGACTGGAAAATTATAAGAGCACTCTCTGAGATTGCTGGAATGACTCTTCCATAT GATACTCTGGATCAAGTAAGGAACAGATTGGAAGAAGTCTCTCCTAATCTTGTTCGATAT GATGATATTGAAGGGGCTAATTACTTCCAGCAAGCAAATGAGCTCTCAAAGCTAGTGAAC CAGCAGCTTCTTGCTGACCCACTTGTTCCACCTCAGCTAACTATAAAAGACTTCTACATG ACAGATTCAATTAGCAGAGCCTCACAGACAATGGCCAAATGTGTCAAAGCTGTCACAGAG GGTGCCCAGGCAGTAGAGGAACCATCCATATGCTGA
- Chromosome Location
- 2
- Locus
- 2q33-q34
- External Identifiers
Resource Link UniProtKB ID P28331 UniProtKB Entry Name NDUS1_HUMAN GenBank Protein ID 38079 GenBank Gene ID X61100 GenAtlas ID NDUFS1 HGNC ID HGNC:7707 - General References
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