47 kDa membrane antigen
Details
- Name
- 47 kDa membrane antigen
- Synonyms
- 47 kDa membrane antigen precursor
- Gene Name
- Not Available
- Organism
- Treponema pallidum (strain Nichols)
- Amino acid sequence
>lcl|BSEQ0011358|47 kDa membrane antigen MKVKYALLSAGALQLLVVGCGSSHHETHYGYATLSYADYWAGELGQSRDVLLAGNAEADR AGDLDAGMFDAVSRATHGHGAFRQQFQYAVEVLGEKVLSKQETEDSRGRKKWEYETDPSV TKMVRASASFQDLGEDGEIKFEAVEGAVALADRASSFMVDSEEYKITNVKVHGMKFVPVA VPHELKGIAKEKFHFVEDSRVTENTNGLKTMLTEDSFSARKVSSMESPHDLVVDTVGTGY HSRFGSDAEASVMLKRADGSELSHREFIDYVMNFNTVRYDYYGDDASYTNLMASYGTKHS ADSWWKTGRVPRISCGINYGFDRFKGSGPGYYRLTLIANGYRDVVADVRFLPKYEGNIDI GLKGKVLTIGGADAETLMDAAVDVFADGQPKLVSDQAVSLGQNVLSADFTPGTEYTVEVR FKEFGSVRAKVVAQ
- Number of residues
- 434
- Molecular Weight
- 47664.955
- Theoretical pI
- 5.34
- GO Classification
- Componentsplasma membrane
- General Function
- Not Available
- Specific Function
- This antigen is a pathogen-specific membrane immunogen. Most abundant of the membrane lipoproteins, only found so far in pathogenic treponemes, suggesting that it is an important structural moiety in the cell envelope of virulent treponemal subspecies.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0011359|47 kDa membrane antigen GTGAAAGTGAAATACGCACTACTTTCTGCCGGAGCGCTGCAGTTGTTGGTTGTAGGCTGT GGCTCGTCTCATCATGAGACGCACTATGGCTATGCGACGCTAAGCTATGCGGACTACTGG GCCGGGGAGTTGGGGCAGAGTAGGGACGTGCTTTTGGCGGGTAATGCCGAGGCGGACCGC GCGGGGGATCTCGACGCAGGCATGTTCGATGCAGTTTCTCGCGCAACCCACGGGCATGGC GCGTTCCGTCAGCAATTTCAGTACGCGGTTGAGGTATTGGGCGAAAAGGTTCTCTCGAAG CAGGAGACCGAAGACAGCAGGGGAAGAAAAAAGTGGGAGTACGAGACTGACCCAAGCGTT ACTAAGATGGTGCGTGCCTCTGCGTCATTTCAGGATTTGGGAGAGGACGGGGAGATTAAG TTTGAAGCAGTCGAGGGTGCAGTAGCGTTGGCGGATCGCGCGAGTTCCTTCATGGTTGAC AGCGAGGAATACAAGATTACGAACGTAAAGGTTCACGGTATGAAGTTTGTCCCAGTTGCG GTTCCTCATGAATTAAAAGGGATTGCAAAGGAGAAGTTTCACTTCGTGGAAGACTCCCGC GTTACGGAGAATACCAACGGCCTTAAGACAATGCTCACTGAGGATAGTTTTTCTGCACGT AAGGTAAGCAGCATGGAGAGCCCGCACGACCTTGTGGTAGACACGGTGGGTACCGGTTAC CACAGCCGTTTTGGTTCGGACGCAGAGGCTTCTGTGATGCTGAAAAGGGCTGATGGCTCT GAGCTGTCGCACCGTGAGTTCATCGACTATGTGATGAACTTCAACACGGTCCGCTACGAC TACTACGGTGATGACGCGAGCTACACCAATCTGATGGCGAGTTATGGCACCAAGCACTCT GCTGACTCCTGGTGGAAGACAGGAAGAGTGCCCCGCATTTCGTGTGGTATCAACTATGGG TTCGATCGGTTTAAAGGTTCAGGGCCGGGATACTACAGGCTGACTTTGATTGCGAACGGG TATAGGGACGTAGTTGCTGATGTGCGCTTCCTTCCCAAGTACGAGGGGAACATCGATATT GGGTTGAAGGGGAAGGTGCTGACCATAGGGGGCGCGGACGCGGAGACTCTGATGGATGCT GCAGTTGACGTGTTTGCCGATGGACAGCCTAAGCTTGTCAGCGATCAAGCGGTGAGCTTG GGGCAGAATGTCCTCTCTGCGGATTTCACTCCCGGCACTGAGTACACGGTTGAGGTTAGG TTCAAGGAATTCGGTTCTGTGCGTGCGAAGGTAGTGGCCCAGTAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P29723 UniProtKB Entry Name TA47_TREPA GenBank Protein ID 155053 GenBank Gene ID M88769 - General References
- Weigel LM, Brandt ME, Norgard MV: Analysis of the N-terminal region of the 47-kilodalton integral membrane lipoprotein of Treponema pallidum. Infect Immun. 1992 Apr;60(4):1568-76. [Article]
- Fraser CM, Norris SJ, Weinstock GM, White O, Sutton GG, Dodson R, Gwinn M, Hickey EK, Clayton R, Ketchum KA, Sodergren E, Hardham JM, McLeod MP, Salzberg S, Peterson J, Khalak H, Richardson D, Howell JK, Chidambaram M, Utterback T, McDonald L, Artiach P, Bowman C, Cotton MD, Fujii C, Garland S, Hatch B, Horst K, Roberts K, Sandusky M, Weidman J, Smith HO, Venter JC: Complete genome sequence of Treponema pallidum, the syphilis spirochete. Science. 1998 Jul 17;281(5375):375-88. [Article]
- Hsu PL, Chamberlain NR, Orth K, Moomaw CR, Zhang LQ, Slaughter CA, Radolf JD, Sell S, Norgard MV: Sequence analysis of the 47-kilodalton major integral membrane immunogen of Treponema pallidum. Infect Immun. 1989 Jan;57(1):196-203. [Article]