cGMP-gated cation channel alpha-1
Details
- Name
- cGMP-gated cation channel alpha-1
- Synonyms
- CNCG
- CNCG1
- CNG channel alpha-1
- CNG-1
- CNG1
- Cyclic nucleotide-gated cation channel 1
- Cyclic nucleotide-gated channel alpha-1
- Cyclic nucleotide-gated channel, photoreceptor
- Rod photoreceptor cGMP-gated channel subunit alpha
- Gene Name
- CNGA1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0009062|cGMP-gated cation channel alpha-1 MKLSMKNNIINTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASTSEESENENP HARGSFSYKSLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPEEKKKKKKEKKSKSDDKN ENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNW TMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKY KSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRI SNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTL TTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQY MHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIF ADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSD GSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGK QILMKDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRLT KVEKFLKPLIDTEFSSIEGPGAESGPIDST
- Number of residues
- 690
- Molecular Weight
- 79584.825
- Theoretical pI
- Not Available
- GO Classification
- FunctionscGMP binding / intracellular cAMP activated cation channel activity / intracellular cGMP activated cation channel activity / voltage-gated potassium channel activityProcessesphototransduction, visible light / potassium ion transmembrane transport / regulation of membrane potential / regulation of rhodopsin mediated signaling pathway / rhodopsin mediated signaling pathway / transport / visual perceptionComponentsintegral component of plasma membrane / photoreceptor outer segment membrane / plasma membrane
- General Function
- Voltage-gated potassium channel activity
- Specific Function
- Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.
- Pfam Domain Function
- Transmembrane Regions
- 165-185 199-217 242-261 300-322 375-394 479-499
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0019714|cGMP-gated cation channel alpha-1 (CNGA1) ATGAAACTATCCATGAAGAACAATATTATCAATACACAGCAGTCTTTTGTAACCATGCCC AATGTGATTGTACCAGATATTGAAAAGGAAATACGAAGGATGGAAAATGGAGCATGCAGC TCCTTTTCTGAGGATGATGACAGTGCCTCTACATCTGAAGAATCAGAGAATGAAAACCCT CATGCAAGGGGTTCCTTTAGTTATAAGTCACTCAGAAAGGGAGGACCATCACAGAGGGAG CAGTACCTGCCTGGTGCCATTGCACTTTTTAATGTGAACAACAGCAGCAATAAGGACCAG GAACCAGAAGAAAAAAAGAAAAAGAAAAAAGAAAAGAAGAGCAAGTCAGATGATAAAAAC GAAAATAAAAACGACCCAGAGAAGAAAAAGAAGAAAAAGGACAAAGAGAAGAAAAAGAAA GAGGAGAAAAGCAAAGATAAGAAAGAAGAGGAGAAGAAAGAAGTTGTGGTTATTGATCCC TCGGGAAACACATATTACAACTGGCTGTTTTGCATCACATTACCTGTTATGTACAACTGG ACAATGGTTATTGCCAGAGCATGTTTTGATGAACTTCAATCTGATTACCTAGAATATTGG CTCATTTTGGATTACGTATCAGACATAGTCTATTTAATCGATATGTTTGTACGAACAAGG ACAGGTTACCTAGAACAAGGACTGCTGGTAAAGGAAGAACTTAAACTCATAAATAAATAT AAATCCAACTTGCAATTTAAACTTGATGTTCTGTCACTGATACCAACTGATTTGCTGTAT TTTAAGTTAGGGTGGAACTATCCAGAAATTAGATTAAACAGGTTGTTACGGTTCTCTCGT ATGTTTGAGTTCTTCCAGAGAACAGAAACAAGGACAAACTATCCAAACATCTTCAGGATT TCCAACCTTGTTATGTATATCGTCATCATTATCCACTGGAATGCATGTGTGTTCTACTCT ATTTCTAAAGCTATTGGATTTGGAAATGATACATGGGTCTACCCTGATATTAATGATCCT GAATTTGGCCGTTTGGCTAGAAAATACGTATACAGCCTTTACTGGTCTACACTGACTTTG ACTACCATTGGTGAAACACCCCCTCCCGTGAGGGATTCTGAGTATGTCTTTGTGGTGGTT GATTTCCTAATTGGAGTGTTAATTTTTGCTACCATCGTTGGTAACATAGGTTCTATGATT TCCAACATGAATGCAGCCAGAGCAGAATTTCAAGCAAGAATTGATGCTATCAAGCAATAT ATGCATTTTCGAAATGTAAGCAAAGATATGGAAAAGAGGGTTATTAAATGGTTTGACTAC CTGTGGACCAACAAAAAAACAGTTGATGAGAAAGAAGTCTTAAAGTATCTACCTGATAAA CTAAGAGCAGAAATTGCCATCAACGTTCACTTAGACACATTAAAAAAGGTACGCATTTTT GCTGATTGTGAAGCTGGTCTGTTGGTGGAGTTGGTCTTGAAATTGCAACCCCAAGTCTAC AGTCCTGGAGATTATATTTGCAAGAAAGGGGATATCGGACGAGAGATGTACATTATCAAG GAAGGCAAACTCGCTGTGGTGGCAGATGATGGAGTCACTCAGTTTGTGGTATTGAGCGAT GGCAGCTACTTCGGTGAGATCAGCATTCTTAACATTAAAGGGAGCAAAGCTGGCAATCGA AGAACGGCCAATATTAAAAGTATTGGCTACTCAGACCTGTTCTGTCTCTCAAAAGATGAC CTCATGGAAGCTCTAACTGAGTACCCAGATGCCAAAACTATGCTGGAAGAGAAAGGGAAG CAGATTTTAATGAAAGATGGTCTACTGGATCTAAACATTGCAAATGCTGGCAGTGATCCT AAAGATCTTGAAGAGAAGGTTACTCGAATGGAGGGGTCAGTAGACCTCCTGCAAACCAGG TTTGCCCGAATCTTGGCTGAGTATGAGTCCATGCAGCAGAAACTGAAACAAAGATTAACC AAGGTTGAGAAATTTCTGAAACCGCTTATTGACACAGAATTTTCAAGTATTGAGGGACCT GGAGCGGAAAGTGGGCCCATCGACTCTACATAG
- Chromosome Location
- 4
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P29973 UniProtKB Entry Name CNGA1_HUMAN HGNC ID HGNC:2148 - General References
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