Lipocalin-1
Details
- Name
- Lipocalin-1
- Synonyms
- Tear lipocalin
- Tear prealbumin
- Tlc
- TP
- VEG protein
- VEGP
- Von Ebner gland protein
- Gene Name
- LCN1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0013952|Lipocalin-1 MKPLLLAVSLGLIAALQAHHLLASDEEIQDVSGTWYLKAMTVDREFPEMNLESVTPMTLT TLEGGNLEAKVTMLISGRCQEVKAVLEKTDEPGKYTADGGKHVAYIIRSHVKDHYIFYCE GELHGKPVRGVKLVGRDPKNNLEALEDFEKAAGARGLSTESILIPRQSETCSPGSD
- Number of residues
- 176
- Molecular Weight
- 19249.845
- Theoretical pI
- Not Available
- GO Classification
- Functionscysteine-type endopeptidase inhibitor activityProcesseslong-chain fatty acid transport / negative regulation of endopeptidase activity / proteolysis / response to stimulus / retina homeostasis / sensory perception of taste / transmembrane transportComponentsextracellular exosome / extracellular region / extracellular space
- General Function
- Cysteine-type endopeptidase inhibitor activity
- Specific Function
- Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket.
- Pfam Domain Function
- Lipocalin (PF00061)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0013953|Lipocalin-1 (LCN1) ATGAAGCCCCTGCTCCTGGCCGTCAGCCTTGGCCTCATTGCTGCCCTGCAGGCCCACCAC CTCCTGGCCTCAGACGAGGAGATTCAGGATGTGTCAGGGACGTGGTATCTGAAGGCCATG ACGGTGGACAGGGAGTTCCCTGAGATGAATCTGGAATCGGTGACACCCATGACCCTCACG ACCCTGGAAGGGGGCAACCTGGAAGCCAAGGTCACCATGCTGATAAGTGGCCGGTGCCAG GAGGTGAAGGCCGTCCTGGAGAAAACTGACGAGCCGGGAAAATACACGGCCGACGGGGGC AAGCACGTGGCATACATCATCAGGTCGCACGTGAAGGACCACTACATCTTTTACTGTGAG GGCGAGCTGCACGGGAAGCCGGTCCGAGGGGTGAAGCTCGTGGGCAGAGACCCCAAGAAC AACCTGGAAGCCTTGGAGGACTTTGAGAAAGCCGCAGGAGCCCGCGGACTCAGCACGGAG AGCATCCTCATCCCCAGGCAGAGCGAAACCTGCTCTCCAGGGAGCGATTAG
- Chromosome Location
- 9
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P31025 UniProtKB Entry Name LCN1_HUMAN HGNC ID HGNC:6525 - General References
- Blaker M, Kock K, Ahlers C, Buck F, Schmale H: Molecular cloning of human von Ebner's gland protein, a member of the lipocalin superfamily highly expressed in lingual salivary glands. Biochim Biophys Acta. 1993 Feb 20;1172(1-2):131-7. [Article]
- Redl B, Holzfeind P, Lottspeich F: cDNA cloning and sequencing reveals human tear prealbumin to be a member of the lipophilic-ligand carrier protein superfamily. J Biol Chem. 1992 Oct 5;267(28):20282-7. [Article]
- Lassagne H, Gachon AM: Cloning of a human lacrimal lipocalin secreted in tears. Exp Eye Res. 1993 May;56(5):605-9. [Article]
- Holzfeind P, Redl B: Structural organization of the gene encoding the human lipocalin tear prealbumin and synthesis of the recombinant protein in Escherichia coli. Gene. 1994 Feb 25;139(2):177-83. [Article]
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- Azkargorta M, Soria J, Ojeda C, Guzman F, Acera A, Iloro I, Suarez T, Elortza F: Human Basal Tear Peptidome Characterization by CID, HCD, and ETD Followed by in Silico and in Vitro Analyses for Antimicrobial Peptide Identification. J Proteome Res. 2015 Jun 5;14(6):2649-58. doi: 10.1021/acs.jproteome.5b00179. Epub 2015 May 20. [Article]
- Wojnar P, Lechner M, Merschak P, Redl B: Molecular cloning of a novel lipocalin-1 interacting human cell membrane receptor using phage display. J Biol Chem. 2001 Jun 8;276(23):20206-12. Epub 2001 Apr 3. [Article]
- Wojnar P, Lechner M, Redl B: Antisense down-regulation of lipocalin-interacting membrane receptor expression inhibits cellular internalization of lipocalin-1 in human NT2 cells. J Biol Chem. 2003 May 2;278(18):16209-15. Epub 2003 Feb 18. [Article]
- Breustedt DA, Korndorfer IP, Redl B, Skerra A: The 1.8-A crystal structure of human tear lipocalin reveals an extended branched cavity with capacity for multiple ligands. J Biol Chem. 2005 Jan 7;280(1):484-93. Epub 2004 Oct 15. [Article]