Hydroxylamine reductase

Details

Name
Hydroxylamine reductase
Synonyms
  • 1.7.99.1
  • HCP
  • Hybrid-cluster protein
  • Prismane protein
Gene Name
hcp
Organism
Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)
Amino acid sequence
>lcl|BSEQ0016902|Hydroxylamine reductase
MFCFQCQETAKNTGCTVKGMCGKPEETANLQDLLIFVLRGIAIYGEKLKELGQPDRSNDD
FVLQGLFATITNANWDDARFEAMISEGLARRDKLRNAFLAVYKAKNGKDFSEPLPEAATW
TGDSTAFAEKAKSVGILATENEDVRSLRELLIIGLKGVAAYAEHAAVLGFRKTEIDEFML
EALASTTKDLSVDEMVALVMKAGGMAVTTMALLDEANTTTYGNPEITQVNIGVGKNPGIL
ISGHDLKDMAELLKQTEGTGVDVYTHGEMLPANYYPAFKKYPHFVGNYGGSWWQQNPEFE
SFNGPILLTTNCLVPLKKENTYLDRLYTTGVVGYEGAKHIADRPAGGAKDFSALIAQAKK
CPPPVEIETGSIVGGFAHHQVLALADKVVEAVKSGAIKRFVVMAGCDGRQKSRSYYTEVA
ENLPKDTVILTAGCAKYRYNKLNLGDIGGIPRVLDAGQCNDSYSLAVIALKLKEVFGLDD
INDLPVSYDIAWYEQKAVAVLLALLFLGVKGIRLGPTLPAFLSPNVAKVLVENFNIKPIG
TVQDDIAAMMAGK
Number of residues
553
Molecular Weight
59978.4
Theoretical pI
5.29
GO Classification
Functions
4 iron, 4 sulfur cluster binding / hydroxylamine reductase activity / metal ion binding
Components
cytoplasm
General Function
Metal ion binding
Specific Function
Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0016903|Hydroxylamine reductase (hcp)
ATGTTTTGCTTCCAGTGTCAGGAAACAGCGAAGAATACGGGATGCACGGTCAAAGGTATG
TGCGGCAAGCCGGAAGAAACCGCCAATTTGCAGGATCTGCTCATTTTTGTGCTGCGTGGC
ATCGCCATTTATGGCGAAAAATTAAAGGAGTTGGGACAGCCGGACCGCTCTAATGACGAC
TTCGTGCTCCAGGGATTATTTGCGACCATCACCAATGCTAACTGGGATGATGCCCGATTT
GAGGCTATGATATCGGAAGGCTTGGCTCGGCGTGACAAGTTGAGAAATGCTTTTCTGGCT
GTTTACAAGGCAAAAAATGGCAAAGATTTCAGCGAGCCGTTGCCCGAAGCCGCGACTTGG
ACTGGGGACTCTACCGCTTTTGCTGAAAAGGCCAAGAGCGTAGGCATTCTGGCAACTGAG
AACGAAGATGTGCGTTCTTTGCGCGAACTGCTCATAATCGGTCTGAAAGGTGTCGCGGCC
TATGCCGAGCACGCTGCTGTACTGGGCTTTCGCAAGACCGAAATCGACGAATTCATGCTT
GAGGCCCTGGCTTCAACGACCAAGGATTTGTCCGTGGATGAAATGGTCGCGCTGGTCATG
AAGGCCGGCGGCATGGCCGTAACCACCATGGCCCTGCTGGACGAGGCCAACACCACTACC
TACGGCAACCCGGAAATCACCCAGGTCAACATCGGCGTGGGCAAGAACCCCGGCATCCTC
ATCAGCGGCCATGACCTGAAGGATATGGCCGAGTTGCTGAAGCAGACCGAGGGCACAGGC
GTGGACGTTTACACCCACGGCGAAATGCTTCCCGCCAACTATTATCCGGCGTTCAAGAAG
TACCCGCATTTCGTGGGGAACTACGGCGGTTCCTGGTGGCAGCAGAATCCCGAATTCGAG
TCCTTCAACGGCCCCATCCTGCTGACCACAAACTGTCTGGTGCCGCTCAAAAAAGAGAAC
ACCTATCTGGACCGTCTCTACACCACTGGCGTGGTTGGGTATGAAGGGGCCAAGCACATC
GCTGACCGGCCTGCGGGAGGAGCCAAGGATTTCTCGGCGCTGATCGCACAGGCCAAGAAA
TGTCCTCCGCCCGTTGAGATCGAGACTGGTAGCATCGTCGGCGGTTTCGCCCATCATCAG
GTACTAGCCTTGGCCGACAAGGTGGTTGAGGCTGTCAAGTCCGGCGCGATCAAGCGCTTT
GTGGTCATGGCCGGGTGTGACGGTCGGCAGAAGTCTCGTTCCTATTACACTGAAGTGGCC
GAAAATTTGCCCAAGGACACCGTGATCTTGACGGCCGGTTGCGCCAAGTACCGCTATAAC
AAACTGAATCTCGGTGACATCGGTGGCATTCCACGTGTGCTGGACGCAGGGCAGTGCAAC
GATTCCTATTCCCTGGCCGTCATTGCTCTGAAACTCAAAGAAGTCTTCGGCCTGGATGAC
ATCAACGATCTGCCCGTATCTTACGATATCGCCTGGTACGAGCAGAAGGCCGTGGCCGTG
CTTCTGGCCCTCCTATTCTTAGGTGTGAAGGGAATCCGCCTCGGACCCACGCTTCCGGCA
TTCCTGTCCCCGAACGTGGCCAAGGTACTGGTTGAAAATTTCAACATCAAACCAATCGGA
ACAGTGCAGGATGACATCGCGGCCATGATGGCGGGTAAATAG
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP31101
UniProtKB Entry NameHCP_DESVH
GenBank Gene IDZ11707
General References
  1. Stokkermans JP, Pierik AJ, Wolbert RB, Hagen WR, Van Dongen WM, Veeger C: The primary structure of a protein containing a putative [6Fe-6S] prismane cluster from Desulfovibrio vulgaris (Hildenborough). Eur J Biochem. 1992 Sep 1;208(2):435-42. [Article]
  2. Heidelberg JF, Seshadri R, Haveman SA, Hemme CL, Paulsen IT, Kolonay JF, Eisen JA, Ward N, Methe B, Brinkac LM, Daugherty SC, Deboy RT, Dodson RJ, Durkin AS, Madupu R, Nelson WC, Sullivan SA, Fouts D, Haft DH, Selengut J, Peterson JD, Davidsen TM, Zafar N, Zhou L, Radune D, Dimitrov G, Hance M, Tran K, Khouri H, Gill J, Utterback TR, Feldblyum TV, Wall JD, Voordouw G, Fraser CM: The genome sequence of the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough. Nat Biotechnol. 2004 May;22(5):554-9. Epub 2004 Apr 11. [Article]
  3. Pierik AJ, Wolbert RB, Mutsaers PH, Hagen WR, Veeger C: Purification and biochemical characterization of a putative [6Fe-6S] prismane-cluster-containing protein from Desulfovibrio vulgaris (Hildenborough). Eur J Biochem. 1992 Jun 15;206(3):697-704. [Article]
  4. Pierik AJ, Hagen WR, Dunham WR, Sands RH: Multi-frequency EPR and high-resolution Mossbauer spectroscopy of a putative [6Fe-6S] prismane-cluster-containing protein from Desulfovibrio vulgaris (Hildenborough). Characterization of a supercluster and superspin model protein. Eur J Biochem. 1992 Jun 15;206(3):705-19. [Article]
  5. Krockel M, Trautwein AX, Arendsen AF, Hagen WR: The prismane protein resolved--Mossbauer investigation of a 4Fe cluster with an unusual mixture of bridging ligands and metal coordinations. Eur J Biochem. 1998 Jan 15;251(1-2):454-61. [Article]
  6. Cooper SJ, Garner CD, Hagen WR, Lindley PF, Bailey S: Hybrid-cluster protein (HCP) from Desulfovibrio vulgaris (Hildenborough) at 1.6 A resolution. Biochemistry. 2000 Dec 12;39(49):15044-54. [Article]
  7. Macedo S, Mitchell EP, Romao CV, Cooper SJ, Coelho R, Liu MY, Xavier AV, LeGall J, Bailey S, Garner DC, Hagen WR, Teixeira M, Carrondo MA, Lindley P: Hybrid cluster proteins (HCPs) from Desulfovibrio desulfuricans ATCC 27774 and Desulfovibrio vulgaris (Hildenborough): X-ray structures at 1.25 A resolution using synchrotron radiation. J Biol Inorg Chem. 2002 Apr;7(4-5):514-25. Epub 2002 Jan 23. [Article]
  8. Aragao D, Macedo S, Mitchell EP, Romao CV, Liu MY, Frazao C, Saraiva LM, Xavier AV, LeGall J, van Dongen WM, Hagen WR, Teixeira M, Carrondo MA, Lindley P: Reduced hybrid cluster proteins (HCP) from Desulfovibrio desulfuricans ATCC 27774 and Desulfovibrio vulgaris (Hildenborough): X-ray structures at high resolution using synchrotron radiation. J Biol Inorg Chem. 2003 May;8(5):540-8. Epub 2003 Feb 15. [Article]
  9. Aragao D, Mitchell EP, Frazao CF, Carrondo MA, Lindley PF: Structural and functional relationships in the hybrid cluster protein family: structure of the anaerobically purified hybrid cluster protein from Desulfovibrio vulgaris at 1.35 A resolution. Acta Crystallogr D Biol Crystallogr. 2008 Jun;64(Pt 6):665-74. doi: 10.1107/S0907444908009165. Epub 2008 May 14. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB02761S-MercaptocysteineexperimentalunknownDetails