Type II inositol 1,4,5-trisphosphate 5-phosphatase
Details
- Name
- Type II inositol 1,4,5-trisphosphate 5-phosphatase
- Synonyms
- 3.1.3.36
- 5PTase
- 75 kDa inositol polyphosphate-5-phosphatase
- OCRL2
- Phosphoinositide 5-phosphatase
- Gene Name
- INPP5B
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0009358|Type II inositol 1,4,5-trisphosphate 5-phosphatase MDQSVAIQETLAEGEYCVIAVQGVLCEGDSRQSRLLGLVRYRLEHGGQEHALFLYTHRRM AITGDDVSLDQIVPVSRDFTLEEVSPDGELYILGSDVTVQLDTAELSLVFQLPFGSQTRM FLHEVARACPGFDSATRDPEFLWLSRYRCAELELEMPTPRGCNSALVTWPGYATIGGGRY PSRKKRWGLEEARPQGAGSVLFWGGAMEKTGFRLMERAHGGGFVWGRSARDGRRDEELEE AGREMSAAAGSRERNTAGGSNFDGLRPNGKGVPMDQSSRGQDKPESLQPRQNKSKSEITD MVRSSTITVSDKAHILSMQKFGLRDTIVKSHLLQKEEDYTYIQNFRFFAGTYNVNGQSPK ECLRLWLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVK LIRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSH LAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDVILWLGDLNYRIEELDVEKV KKLIEEKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTFQPTYKYDTGSDDWDTSEKCRAP AWCDRILWKGKNITQLSYQSHMALKTSDHKPVSSVFDIGVRVVNDELYRKTLEEIVRSLD KMENANIPSVSLSKREFCFQNVKYMQLKVESFTIHNGQVPCHFEFINKPDEESYCKQWLN ANPSRGFLLPDSDVEIDLELFVNKMTATKLNSGEDKIEDILVLHLDRGKDYFLSVSGNYL PSCFGSPIHTLCYMREPILDLPLETISELTLMPVWTGDDGSQLDSPMEIPKELWMMVDYL YRNAVQQEDLFQQPGLRSEFEHIRDCLDTGMIDNLSASNHSVAEALLLFLESLPEPVICY STYHNCLECSGNYTASKQVISTLPIFHKNVFHYLMAFLRELLKNSAKNHLDENILASIFG SLLLRNPAGHQKLDMTEKKKAQEFIHQFLCNPL
- Number of residues
- 993
- Molecular Weight
- 112851.2
- Theoretical pI
- Not Available
- GO Classification
- Functionsinositol-1,4,5-trisphosphate 5-phosphatase activity / metal ion binding / phosphatidylinositol-4,5-bisphosphate 5-phosphatase activityProcessesin utero embryonic development / inositol phosphate metabolic process / phosphatidylinositol dephosphorylation / regulation of protein processing / regulation of small GTPase mediated signal transduction / small GTPase mediated signal transduction / small molecule metabolic process / sperm motility / spermatogenesisComponentscytoplasm / cytosol / early endosome membrane / endoplasmic reticulum-Golgi intermediate compartment / Golgi apparatus / integral component of membrane / membrane / phagocytic vesicle membrane / plasma membrane
- General Function
- Phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
- Specific Function
- Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0013109|Type II inositol 1,4,5-trisphosphate 5-phosphatase (INPP5B) ATGTCTGCCGCCGCCGGCTCTCGGGAGCGCAACACTGCAGGTGGTTCTAACTTTGATGGT TTGAGACCAAATGGGAAGGGAGTGCCTATGGACCAAAGCTCCAGGGGTCAAGATAAACCA GAAAGCTTGCAACCAAGACAGAATAAATCCAAGTCCGAAATTACTGACATGGTTCGCTCC TCCACTATCACAGTGTCGGACAAGGCTCATATTTTATCCATGCAGAAGTTTGGACTGCGA GATACAATTGTGAAATCACATCTACTACAGAAAGAAGAGGATTACACCTATATCCAGAAC TTCAGGTTTTTTGCGGGAACATACAATGTAAATGGGCAGTCCCCCAAAGAATGCCTCCGG CTGTGGCTGAGCAATGGTATCCAGGCCCCAGATGTCTATTGTGTAGGGTTCCAGGAGCTT GATCTGAGTAAGGAAGCTTTTTTCTTTCACGATACCCCAAAGGAGGAAGAGTGGTTCAAA GCTGTGTCAGAGGGTCTTCATCCAGATGCCAAATATGCAAAGGTGAAGCTTATCCGACTG GTTGGGATTATGCTGCTGTTATATGTCAAACAGGAGCATGCAGCTTATATCTCAGAAGTG GAAGCCGAGACTGTGGGGACAGGAATCATGGGGAGGATGGGCAACAAGGGAGGCGTGGCG ATCAGGTTCCAGTTCCACAACACCAGCATCTGCGTTGTGAATTCTCACTTGGCAGCCCAC ATTGAAGAGTATGAGAGGAGGAACCAGGACTATAAGGACATTTGTTCTCGAATGCAGTTT TGTCAGCCTGACCCAAGCCTTCCCCCTCTCACCATCAGCAACCATGATGTGATCTTGTGG CTGGGGGACCTCAACTACAGGATAGAAGAGCTGGATGTGGAAAAAGTGAAAAAGCTCATC GAAGAGAAGGACTTTCAAATGCTGTATGCATATGATCAGCTGAAAATTCAGGTGGCCGCA AAGACTGTCTTTGAAGGCTTCACAGAGGGTGAGCTCACATTCCAGCCTACTTACAAGTAT GATACGGGCTCTGACGACTGGGATACCAGTGAGAAGTGCCGTGCTCCTGCCTGGTGTGAT CGGATTCTCTGGAAAGGGAAGAACATCACTCAGCTGAGTTACCAGAGCCACATGGCCCTG AAGACCAGTGACCACAAGCCTGTCAGCTCAGTGTTTGACATCGGGGTGAGGGTCGTAAAT GACGAGCTTTACCGGAAGACACTGGAGGAAATTGTTCGCTCCCTGGATAAGATGGAAAAT GCCAACATTCCTTCTGTGTCCCTGTCCAAGCGAGAGTTCTGTTTTCAGAATGTGAAGTAC ATGCAATTGAAAGTAGAATCCTTTACAATTCATAATGGACAAGTACCCTGTCATTTTGAA TTCATCAACAAGCCTGATGAAGAGTCTTACTGTAAGCAGTGGCTGAATGCCAACCCCAGC AGAGGCTTCCTCCTGCCAGATTCTGATGTTGAGATTGACTTGGAGCTCTTCGTAAATAAG ATGACAGCTACAAAGCTCAACTCGGGTGAAGACAAAATTGAGGACATTCTGGTTCTGCAC TTGGACAGGGGAAAGGATTACTTTTTGTCTGTGTCTGGGAACTACCTGCCCAGCTGTTTT GGGTCTCCCATTCATACACTGTGTTACATGAGAGAGCCAATCTTGGACCTACCACTTGAA ACCATTAGTGAGCTGACTCTGATGCCAGTATGGACTGGAGATGATGGGAGCCAGTTGGAT AGCCCCATGGAAATCCCCAAAGAGCTCTGGATGATGGTTGATTACCTGTACCGAAATGCT GTCCAGCAGGAAGATCTGTTTCAGCAACCAGGCCTGAGGTCAGAATTTGAACATATCAGG GACTGCTTGGATACTGGAATGATTGATAACCTCTCTGCCAGCAATCATTCTGTAGCCGAA GCCCTGCTGCTTTTCCTGGAGAGCCTTCCAGAGCCTGTCATCTGTTACAGCACCTACCAT AACTGCTTGGAGTGTTCTGGCAACTACACAGCAAGCAAACAGGTCATTTCTACTCTCCCC ATATTCCACAAAAATGTCTTCCACTACTTGATGGCGTTTTTGCGAGAACTGCTGAAAAAT TCAGCAAAAAATCATTTGGATGAGAATATTCTAGCTAGCATATTTGGCAGCTTATTGCTT CGAAACCCAGCTGGTCACCAAAAGCTTGATATGACAGAGAAGAAGAAGGCTCAAGAATTT ATTCACCAGTTCCTCTGCAACCCACTCTGA
- Chromosome Location
- 1
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P32019 UniProtKB Entry Name I5P2_HUMAN HGNC ID HGNC:6077 - General References
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