Peroxiredoxin-2

Details

Name
Peroxiredoxin-2
Synonyms
  • 1.11.1.15
  • Natural killer cell-enhancing factor B
  • NKEF-B
  • NKEFB
  • PRP
  • TDPX1
  • Thiol-specific antioxidant protein
  • Thioredoxin peroxidase 1
  • Thioredoxin-dependent peroxide reductase 1
  • TSA
Gene Name
PRDX2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0003907|Peroxiredoxin-2
MASGNARIGKPAPDFKATAVVDGAFKEVKLSDYKGKYVVLFFYPLDFTFVCPTEIIAFSN
RAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGGLGPLNIPLLADVTRRLSEDYGVLKT
DEGIAYRGLFIIDGKGVLRQITVNDLPVGRSVDEALRLVQAFQYTDEHGEVCPAGWKPGS
DTIKPNVDDSKEYFSKHN
Number of residues
198
Molecular Weight
21891.725
Theoretical pI
5.75
GO Classification
Functions
antioxidant activity / thioredoxin peroxidase activity
Processes
activation of MAPK activity / cellular response to oxidative stress / gene expression / homeostasis of number of cells / hydrogen peroxide catabolic process / negative regulation of apoptotic process / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / negative regulation of lipopolysaccharide-mediated signaling pathway / negative regulation of NF-kappaB transcription factor activity / negative regulation of reactive oxygen species metabolic process / negative regulation of T cell differentiation / positive regulation of blood coagulation / regulation of apoptotic process / regulation of hydrogen peroxide metabolic process / removal of superoxide radicals / respiratory burst involved in inflammatory response / response to lipopolysaccharide / response to oxidative stress / response to reactive oxygen species / T cell proliferation / thymus development / transcription initiation from RNA polymerase II promoter
Components
cytoplasm / cytosol / extracellular exosome / mitochondrion / myelin sheath
General Function
Thioredoxin peroxidase activity
Specific Function
Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0021850|Peroxiredoxin-2 (PRDX2)
ATGGCCTCCGGTAACGCGCGCATCGGAAAGCCAGCCCCTGACTTCAAGGCCACAGCGGTG
GTTGATGGCGCCTTCAAAGAGGTGAAGCTGTCGGACTACAAAGGGAAGTACGTGGTCCTC
TTTTTCTACCCTCTGGACTTCACTTTTGTGTGCCCCACCGAGATCATCGCGTTCAGCAAC
CGTGCAGAGGACTTCCGCAAGCTGGGCTGTGAAGTGCTGGGCGTCTCGGTGGACTCTCAG
TTCACCCACCTGGCTTGGATCAACACCCCCCGGAAAGAGGGAGGCTTGGGCCCCCTGAAC
ATCCCCCTGCTTGCTGACGTGACCAGACGCTTGTCTGAGGATTACGGCGTGCTGAAAACA
GATGAGGGCATTGCCTACAGGGGCCTCTTTATCATCGATGGCAAGGGTGTCCTTCGCCAG
ATCACTGTTAATGATTTGCCTGTGGGACGCTCCGTGGATGAGGCTCTGCGGCTGGTCCAG
GCCTTCCAGTACACAGACGAGCATGGGGAAGTTTGTCCCGCTGGCTGGAAGCCTGGCAGT
GACACGATTAAGCCCAACGTGGATGACAGCAAGGAATATTTCTCCAAACACAATTAG
Chromosome Location
19
Locus
19p13.2
External Identifiers
ResourceLink
UniProtKB IDP32119
UniProtKB Entry NamePRDX2_HUMAN
GenBank Protein ID438069
GenBank Gene IDZ22548
GenAtlas IDPRDX2
HGNC IDHGNC:9353
General References
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  6. Cha MK, Kim IH: Thioredoxin-linked peroxidase from human red blood cell: evidence for the existence of thioredoxin and thioredoxin reductase in human red blood cell. Biochem Biophys Res Commun. 1995 Dec 26;217(3):900-7. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB021533-sulfino-L-alanineexperimentalunknownDetails
DB04048N-Carbamoyl-AlanineexperimentalunknownDetails
DB09130Copperapproved, investigationalunknownDetails