Deoxycytidylate deaminase

Details

Name
Deoxycytidylate deaminase
Synonyms
  • 3.5.4.12
  • dCMP deaminase
Gene Name
DCTD
Organism
Humans
Amino acid sequence
>lcl|BSEQ0008551|Deoxycytidylate deaminase
MSEVSCKKRDDYLEWPEYFMAVAFLSAQRSKDPNSQVGACIVNSENKIVGIGYNGMPNGC
SDDVLPWRRTAENKLDTKYPYVCHAELNAIMNKNSTDVKGCSMYVALFPCNECAKLIIQA
GIKEVIFMSDKYHDSDEATAARLLFNMAGVTFRKFIPKCSKIVIDFDSINSRPSQKLQ
Number of residues
178
Molecular Weight
20015.805
Theoretical pI
Not Available
GO Classification
Functions
dCMP deaminase activity / zinc ion binding
Processes
nucleobase-containing small molecule metabolic process / nucleotide biosynthetic process / pyrimidine nucleobase metabolic process / pyrimidine nucleoside biosynthetic process / pyrimidine nucleotide metabolic process / small molecule metabolic process
Components
cytosol / extracellular exosome
General Function
Zinc ion binding
Specific Function
Supplies the nucleotide substrate for thymidylate synthetase.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0013268|Deoxycytidylate deaminase (DCTD)
ATGGTGGGCGGGGGCCAGCCGTGCGGACCCAACATGAGTGAAGTTTCCTGCAAGAAACGG
GACGACTATTTGGAATGGCCAGAGTATTTTATGGCTGTGGCCTTCTTATCAGCACAGAGA
AGCAAAGATCCAAATTCCCAGGTCGGCGCCTGCATCGTGAATTCAGAAAACAAGATTGTC
GGGATTGGGTACAATGGGATGCCAAATGGGTGCAGTGATGACGTGTTGCCTTGGAGAAGG
ACAGCAGAGAATAAGCTGGACACCAAATACCCGTACGTGTGCCATGCGGAGCTGAATGCC
ATCATGAACAAAAATTCGACCGATGTGAAAGGCTGTAGTATGTATGTTGCCTTGTTCCCT
TGTAATGAATGCGCTAAGCTCATCATCCAGGCAGGTATAAAAGAAGTGATTTTCATGTCT
GATAAATACCATGATAGTGACGAGGCAACTGCTGCGAGGCTCCTGTTTAATATGGCCGGG
GTGACATTCCGGAAATTCATACCGAAGTGCAGCAAGATTGTCATTGACTTTGATTCAATT
AACAGCAGACCGAGTCAAAAGCTTCAGTGA
Chromosome Location
4
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP32321
UniProtKB Entry NameDCTD_HUMAN
HGNC IDHGNC:2710
General References
  1. Weiner KX, Weiner RS, Maley F, Maley GF: Primary structure of human deoxycytidylate deaminase and overexpression of its functional protein in Escherichia coli. J Biol Chem. 1993 Jun 15;268(17):12983-9. [Article]
  2. Weiner KX, Ciesla J, Jaffe AB, Ketring R, Maley F, Maley GF: Chromosomal location and structural organization of the human deoxycytidylate deaminase gene. J Biol Chem. 1995 Aug 11;270(32):18727-9. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00987Cytarabineapproved, investigationalunknownsubstrateDetails