Melanocortin receptor 5
Details
- Name
- Melanocortin receptor 5
- Synonyms
- MC-2
- MC5-R
- Gene Name
- MC5R
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052047|Melanocortin receptor 5 MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGA IVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDS MICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILY SESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTV TMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQ EMRKTFKEIICCRGFRIACSFPRRD
- Number of residues
- 325
- Molecular Weight
- 36600.21
- Theoretical pI
- Not Available
- GO Classification
- Functionshormone binding / melanocortin receptor activityProcessesadenylate cyclase-activating G protein-coupled receptor signaling pathway / G protein-coupled receptor signaling pathway / G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerComponentsintegral component of plasma membrane / plasma membrane
- General Function
- Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.
- Specific Function
- Hormone binding
- Pfam Domain Function
- 7tm_1 (PF00001)
- Transmembrane Regions
- 38-61 74-97 115-138 156-179 187-211 240-265 274-297
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0052048|Melanocortin receptor 5 (MC5R) ATGAATTCCTCATTTCACCTGCATTTCTTGGATCTCAACCTGAATGCCACAGAGGGCAAC CTTTCAGGACCCAATGTCAAAAACAAGTCTTCACCATGTGAAGACATGGGCATTGCTGTG GAGGTGTTTCTCACTCTGGGTGTCATCAGCCTCTTGGAGAACATCTTGGTCATAGGGGCC ATAGTGAAGAACAAAAACCTGCACTCCCCCATGTACTTCTTCGTGTGCAGCCTGGCAGTG GCGGACATGCTGGTGAGCATGTCCAGTGCCTGGGAGACCATCACCATCTACCTACTCAAC AACAAGCACCTAGTGATAGCAGACGCCTTTGTGCGCCACATTGACAATGTGTTTGACTCC ATGATCTGCATTTCCGTGGTGGCATCCATGTGCAGCTTACTGGCCATTGCAGTGGATAGG TACGTCACCATCTTCTACGCCCTGCGCTACCACCACATCATGACGGCGAGGCGCTCAGGG GCCATCATCGCCGGCATCTGGGCTTTCTGCACGGGCTGCGGCATTGTCTTCATCCTGTAC TCAGAATCCACCTACGTCATCCTGTGCCTCATCTCCATGTTCTTCGCTATGCTGTTCCTC CTGGTGTCTCTGTACATACACATGTTCCTCCTGGCGCGGACTCACGTCAAGCGGATCGCG GCTCTGCCCGGGGCCAGCTCTGCGCGGCAGAGGACCAGCATGCAGGGCGCGGTCACCGTC ACCATGCTGCTGGGCGTGTTTACCGTGTGCTGGGCCCCGTTCTTCCTTCATCTCACTTTA ATGCTTTCTTGCCCTCAGAACCTCTACTGCTCTCGCTTCATGTCTCACTTCAATATGTAC CTCATACTCATCATGTGTAATTCCGTGATGGACCCTCTCATATATGCCTTCCGCAGCCAA GAGATGCGGAAGACCTTTAAGGAGATTATTTGCTGCCGTGGTTTCAGGATCGCCTGCAGC TTTCCCAGAAGGGATTAA
- Chromosome Location
- 18
- Locus
- 18p11.21
- External Identifiers
Resource Link UniProtKB ID P33032 UniProtKB Entry Name MC5R_HUMAN HGNC ID HGNC:6933 - General References
- Chhajlani V, Muceniece R, Wikberg JE: Molecular cloning of a novel human melanocortin receptor. Biochem Biophys Res Commun. 1993 Sep 15;195(2):866-73. [Article]
- Griffon N, Mignon V, Facchinetti P, Diaz J, Schwartz JC, Sokoloff P: Molecular cloning and characterization of the rat fifth melanocortin receptor. Biochem Biophys Res Commun. 1994 Apr 29;200(2):1007-14. [Article]
- Fathi Z, Iben LG, Parker EM: Cloning, expression, and tissue distribution of a fifth melanocortin receptor subtype. Neurochem Res. 1995 Jan;20(1):107-13. [Article]
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- Frandberg PA, Xu X, Chhajlani V: Glutamine235 and arginine272 in human melanocortin 5 receptor determines its low affinity to MSH. Biochem Biophys Res Commun. 1997 Jul 18;236(2):489-92. [Article]
- Hatta N, Dixon C, Ray AJ, Phillips SR, Cunliffe WJ, Dale M, Todd C, Meggit S, Birch-MacHin MA, Rees JL: Expression, candidate gene, and population studies of the melanocortin 5 receptor. J Invest Dermatol. 2001 Apr;116(4):564-70. [Article]