Tyrosine aminotransferase
Details
- Name
- Tyrosine aminotransferase
- Synonyms
- 2.6.1.5
- L-tyrosine:2-oxoglutarate aminotransferase
- TAT
- Gene Name
- Not Available
- Organism
- Trypanosoma cruzi
- Amino acid sequence
>lcl|BSEQ0012238|Tyrosine aminotransferase MSSWDVSMSNHAGLVFNPIRTVSDNAKPSPSPKPIIKLSVGDPTLDKNLLTSAAQIKKLK EAIDSQECNGYFPTVGSPEAREAVATWWRNSFVHKEELKSTIVKDNVVLCSGGSHGILMA ITAICDAGDYALVPQPGFPHYETVCKAYGIGMHFYNCRPENDWEADLDEIRRLKDDKTKL LIVTNPSNPCGSNFSRKHVEDIVRLAEELRLPLFSDEIYAGMVFKGKDPNATFTSVADFE TTVPRVILGGTAKNLVVPGWRLGWLLYVDPHGNGPSFLEGLKRVGMLVCGPCTVVQAALG EALLNTPQEHLDQIVAKIEESAMYLYNHIGECIGLAPTMPRGAMYLMSRIDLEKYRDIKT DVEFFEKLLEEENVQVLPGTIFHAPGFTRLTTTRPVEVYREAVERIKAFCQRHAAV
- Number of residues
- 416
- Molecular Weight
- 46166.605
- Theoretical pI
- 6.14
- GO Classification
- FunctionsL-phenylalanine / L-tyrosine / pyridoxal phosphate bindingProcessesbiosynthetic process / L-phenylalanine catabolic process / tyrosine catabolic processComponentsmitochondrion
- General Function
- Pyridoxal phosphate binding
- Specific Function
- Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate (By similarity).
- Pfam Domain Function
- Aminotran_1_2 (PF00155)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P33447 UniProtKB Entry Name ATTY_TRYCR - General References
- Bontempi EJ, Bua J, Aslund L, Porcel B, Segura EL, Henriksson J, Orn A, Pettersson U, Ruiz AM: Isolation and characterization of a gene from Trypanosoma cruzi encoding a 46-kilodalton protein with homology to human and rat tyrosine aminotransferase. Mol Biochem Parasitol. 1993 Jun;59(2):253-62. [Article]
- Montemartini M, Santome JA, Cazzulo JJ, Nowicki C: Purification and partial structural and kinetic characterization of tyrosine aminotransferase from epimastigotes of Trypanosoma cruzi. Biochem J. 1993 Jun 15;292 ( Pt 3):901-6. [Article]
- Blankenfeldt W, Nowicki C, Montemartini-Kalisz M, Kalisz HM, Hecht HJ: Crystal structure of Trypanosoma cruzi tyrosine aminotransferase: substrate specificity is influenced by cofactor binding mode. Protein Sci. 1999 Nov;8(11):2406-17. [Article]