Tyrosine aminotransferase

Details

Name
Tyrosine aminotransferase
Synonyms
  • 2.6.1.5
  • L-tyrosine:2-oxoglutarate aminotransferase
  • TAT
Gene Name
Not Available
Organism
Trypanosoma cruzi
Amino acid sequence
>lcl|BSEQ0012238|Tyrosine aminotransferase
MSSWDVSMSNHAGLVFNPIRTVSDNAKPSPSPKPIIKLSVGDPTLDKNLLTSAAQIKKLK
EAIDSQECNGYFPTVGSPEAREAVATWWRNSFVHKEELKSTIVKDNVVLCSGGSHGILMA
ITAICDAGDYALVPQPGFPHYETVCKAYGIGMHFYNCRPENDWEADLDEIRRLKDDKTKL
LIVTNPSNPCGSNFSRKHVEDIVRLAEELRLPLFSDEIYAGMVFKGKDPNATFTSVADFE
TTVPRVILGGTAKNLVVPGWRLGWLLYVDPHGNGPSFLEGLKRVGMLVCGPCTVVQAALG
EALLNTPQEHLDQIVAKIEESAMYLYNHIGECIGLAPTMPRGAMYLMSRIDLEKYRDIKT
DVEFFEKLLEEENVQVLPGTIFHAPGFTRLTTTRPVEVYREAVERIKAFCQRHAAV
Number of residues
416
Molecular Weight
46166.605
Theoretical pI
6.14
GO Classification
Functions
L-phenylalanine / L-tyrosine / pyridoxal phosphate binding
Processes
biosynthetic process / L-phenylalanine catabolic process / tyrosine catabolic process
Components
mitochondrion
General Function
Pyridoxal phosphate binding
Specific Function
Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate (By similarity).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP33447
UniProtKB Entry NameATTY_TRYCR
General References
  1. Bontempi EJ, Bua J, Aslund L, Porcel B, Segura EL, Henriksson J, Orn A, Pettersson U, Ruiz AM: Isolation and characterization of a gene from Trypanosoma cruzi encoding a 46-kilodalton protein with homology to human and rat tyrosine aminotransferase. Mol Biochem Parasitol. 1993 Jun;59(2):253-62. [Article]
  2. Montemartini M, Santome JA, Cazzulo JJ, Nowicki C: Purification and partial structural and kinetic characterization of tyrosine aminotransferase from epimastigotes of Trypanosoma cruzi. Biochem J. 1993 Jun 15;292 ( Pt 3):901-6. [Article]
  3. Blankenfeldt W, Nowicki C, Montemartini-Kalisz M, Kalisz HM, Hecht HJ: Crystal structure of Trypanosoma cruzi tyrosine aminotransferase: substrate specificity is influenced by cofactor binding mode. Protein Sci. 1999 Nov;8(11):2406-17. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04083N(6)-(pyridoxal phosphate)-L-lysineexperimentalunknownDetails