Bifunctional PGK/TIM

Details

Name
Bifunctional PGK/TIM
Synonyms
  • 2.7.2.3
  • TIM
Gene Name
pgk/tpi
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Amino acid sequence
>lcl|BSEQ0016495|Bifunctional PGK/TIM
MEKMTIRDVDLKGKRVIMRVDFNVPVKDGVVQDDTRIRAALPTIKYALEQGAKVILLSHL
GRPKGEPSPEFSLAPVAKRLSELLGKEVKFVPAVVGDEVKKAVEELKEGEVLLLENTRFH
PGETKNDPELAKFWASLADIHVNDAFGTAHRAHASNVGIAQFIPSVAGFLMEKEIKFLSK
VTYNPEKPYVVVLGGAKVSDKIGVITNLMEKADRILIGGAMMFTFLKALGKEVGSSRVEE
DKIDLAKELLEKAKEKGVEIVLPVDAVIAQKIEPGVEKKVVRIDDGIPEGWMGLDIGPET
IELFKQKLSDAKTVVWNGPMGVFEIDDFAEGTKQVALAIAALTEKGAITVVGGGDSAAAV
NKFGLEDKFSHVSTGGGASLEFLEGKELPGIASIADKKKITRKLILAGNWKMHKTISEAK
KFVSLLVNELHDVKEFEIVVCPPFTALSEVGEILSGRNIKLGAQNVFYEDQGAFTGEISP
LMLQEIGVEYVIVGHSERRRIFKEDDEFINRKVKAVLEKGMTPILCVGETLEEREKGLTF
CVVEKQVREGFYGLDKEEAKRVVIAYEPVWAIGTGRVATPQQAQEVHAFIRKLLSEMYDE
ETAGSIRILYGGSIKPDNFLGLIVQKDIDGGLVGGASLKESFIELARIMRGVIS
Number of residues
654
Molecular Weight
71584.555
Theoretical pI
5.67
GO Classification
Functions
ATP binding / phosphoglycerate kinase activity / triose-phosphate isomerase activity
Processes
fatty acid biosynthetic process / gluconeogenesis / glycolytic process / pentose-phosphate shunt
Components
cytoplasm
General Function
Triose-phosphate isomerase activity
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0016496|Bifunctional PGK/TIM (pgk/tpi)
ATGGAAAAAATGACCATAAGAGATGTTGATCTGAAAGGCAAGAGAGTCATAATGAGAGTG
GACTTCAACGTTCCAGTGAAGGATGGGGTCGTTCAGGACGACACGAGAATAAGAGCCGCC
CTTCCAACGATAAAGTACGCTCTTGAACAGGGTGCAAAGGTGATACTCCTGTCCCATCTT
GGAAGGCCCAAGGGAGAACCTTCACCAGAGTTCAGCCTCGCACCTGTCGCCAAAAGACTC
TCTGAGCTTCTTGGAAAAGAAGTGAAGTTTGTTCCCGCTGTTGTCGGTGATGAGGTGAAA
AAGGCCGTTGAGGAGCTCAAAGAGGGAGAGGTTCTCCTCCTTGAAAACACCAGATTCCAC
CCGGGAGAGACCAAGAACGATCCTGAACTCGCGAAGTTCTGGGCTAGCCTCGCCGATATT
CACGTGAACGATGCCTTCGGAACGGCGCACAGGGCACACGCTTCCAACGTTGGAATCGCA
CAGTTTATTCCCAGCGTAGCGGGATTCCTCATGGAAAAAGAGATAAAGTTCCTTTCCAAG
GTGACTTATAATCCAGAAAAACCGTACGTTGTGGTTCTTGGAGGAGCAAAGGTATCTGAC
AAAATCGGCGTCATCACGAACCTCATGGAGAAAGCCGACAGAATTCTCATAGGTGGAGCC
ATGATGTTCACCTTCCTGAAGGCTCTTGGCAAAGAGGTTGGATCGTCCAGGGTTGAAGAA
GACAAGATCGACCTCGCAAAAGAACTCCTCGAAAAAGCGAAAGAAAAGGGTGTTGAGATC
GTTCTTCCCGTTGATGCCGTTATCGCTCAGAAGATCGAACCCGGTGTGGAAAAGAAGGTT
GTCAGAATCGACGACGGGATACCCGAAGGATGGATGGGCCTCGACATAGGACCCGAGACA
ATTGAGCTCTTCAAGCAGAAGCTCTCCGATGCAAAAACCGTTGTCTGGAACGGGCCAATG
GGAGTCTTCGAAATAGACGATTTCGCTGAAGGCACGAAGCAGGTCGCACTTGCGATCGCA
GCGCTCACGGAAAAGGGAGCGATCACCGTTGTGGGTGGAGGAGACAGCGCCGCGGCGGTG
AACAAGTTCGGTCTGGAAGACAAATTCTCCCACGTTTCAACGGGCGGAGGGGCTTCTCTC
GAATTCCTTGAAGGAAAAGAACTTCCTGGTATTGCCAGCATCGCGGATAAAAAAAAAATA
ACTCGTAAACTGATCCTCGCTGGGAACTGGAAGATGCATAAAACGATCTCGGAAGCGAAA
AAGTTTGTGTCGCTGCTCGTGAACGAACTTCACGACGTGAAAGAGTTCGAAATAGTGGTC
TGTCCTCCGTTCACAGCTCTATCTGAAGTGGGGGAAATACTCTCTGGTAGAAACATCAAA
TTGGGAGCTCAAAACGTTTTCTACGAAGACCAGGGAGCGTTCACCGGGGAGATTTCTCCT
CTCATGCTGCAAGAGATCGGCGTTGAATACGTGATCGTGGGACATTCCGAGAGAAGGCGT
ATTTTCAAAGAAGACGACGAGTTCATAAACAGGAAAGTGAAAGCGGTGCTTGAAAAAGGT
ATGACTCCTATTCTCTGCGTTGGAGAAACACTCGAGGAAAGAGAGAAAGGGCTCACTTTC
TGCGTTGTGGAAAAACAGGTGAGAGAAGGTTTCTACGGTCTCGACAAAGAGGAAGCAAAG
AGAGTGGTAATAGCTTACGAGCCAGTCTGGGCAATCGGGACAGGAAGGGTGGCGACACCA
CAGCAGGCACAGGAAGTACACGCGTTCATAAGAAAGCTGCTCTCAGAGATGTACGACGAG
GAAACAGCGGGATCGATAAGGATTCTCTACGGTGGAAGCATAAAGCCGGACAATTTCCTC
GGTCTCATCGTTCAGAAGGATATAGATGGTGGTCTCGTTGGAGGAGCGAGTCTCAAAGAG
TCTTTCATAGAACTTGCACGAATAATGAGAGGTGTGATTTCCTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP36204
UniProtKB Entry NamePGKT_THEMA
GenBank Protein ID450686
GenBank Gene IDX75437
General References
  1. Schurig H, Beaucamp N, Ostendorp R, Jaenicke R, Adler E, Knowles JR: Phosphoglycerate kinase and triosephosphate isomerase from the hyperthermophilic bacterium Thermotoga maritima form a covalent bifunctional enzyme complex. EMBO J. 1995 Feb 1;14(3):442-51. [Article]
  2. Nelson KE, Clayton RA, Gill SR, Gwinn ML, Dodson RJ, Haft DH, Hickey EK, Peterson JD, Nelson WC, Ketchum KA, McDonald L, Utterback TR, Malek JA, Linher KD, Garrett MM, Stewart AM, Cotton MD, Pratt MS, Phillips CA, Richardson D, Heidelberg J, Sutton GG, Fleischmann RD, Eisen JA, White O, Salzberg SL, Smith HO, Venter JC, Fraser CM: Evidence for lateral gene transfer between Archaea and bacteria from genome sequence of Thermotoga maritima. Nature. 1999 May 27;399(6734):323-9. [Article]
  3. Auerbach G, Huber R, Grattinger M, Zaiss K, Schurig H, Jaenicke R, Jacob U: Closed structure of phosphoglycerate kinase from Thermotoga maritima reveals the catalytic mechanism and determinants of thermal stability. Structure. 1997 Nov 15;5(11):1475-83. [Article]
  4. Maes D, Zeelen JP, Thanki N, Beaucamp N, Alvarez M, Thi MH, Backmann J, Martial JA, Wyns L, Jaenicke R, Wierenga RK: The crystal structure of triosephosphate isomerase (TIM) from Thermotoga maritima: a comparative thermostability structural analysis of ten different TIM structures. Proteins. 1999 Nov 15;37(3):441-53. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB045103-phospho-D-glyceric acidexperimentalunknownDetails