Bifunctional PGK/TIM
Details
- Name
- Bifunctional PGK/TIM
- Synonyms
- 2.7.2.3
- TIM
- Gene Name
- pgk/tpi
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Amino acid sequence
>lcl|BSEQ0016495|Bifunctional PGK/TIM MEKMTIRDVDLKGKRVIMRVDFNVPVKDGVVQDDTRIRAALPTIKYALEQGAKVILLSHL GRPKGEPSPEFSLAPVAKRLSELLGKEVKFVPAVVGDEVKKAVEELKEGEVLLLENTRFH PGETKNDPELAKFWASLADIHVNDAFGTAHRAHASNVGIAQFIPSVAGFLMEKEIKFLSK VTYNPEKPYVVVLGGAKVSDKIGVITNLMEKADRILIGGAMMFTFLKALGKEVGSSRVEE DKIDLAKELLEKAKEKGVEIVLPVDAVIAQKIEPGVEKKVVRIDDGIPEGWMGLDIGPET IELFKQKLSDAKTVVWNGPMGVFEIDDFAEGTKQVALAIAALTEKGAITVVGGGDSAAAV NKFGLEDKFSHVSTGGGASLEFLEGKELPGIASIADKKKITRKLILAGNWKMHKTISEAK KFVSLLVNELHDVKEFEIVVCPPFTALSEVGEILSGRNIKLGAQNVFYEDQGAFTGEISP LMLQEIGVEYVIVGHSERRRIFKEDDEFINRKVKAVLEKGMTPILCVGETLEEREKGLTF CVVEKQVREGFYGLDKEEAKRVVIAYEPVWAIGTGRVATPQQAQEVHAFIRKLLSEMYDE ETAGSIRILYGGSIKPDNFLGLIVQKDIDGGLVGGASLKESFIELARIMRGVIS
- Number of residues
- 654
- Molecular Weight
- 71584.555
- Theoretical pI
- 5.67
- GO Classification
- FunctionsATP binding / phosphoglycerate kinase activity / triose-phosphate isomerase activityProcessesfatty acid biosynthetic process / gluconeogenesis / glycolytic process / pentose-phosphate shuntComponentscytoplasm
- General Function
- Triose-phosphate isomerase activity
- Specific Function
- Not Available
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0016496|Bifunctional PGK/TIM (pgk/tpi) ATGGAAAAAATGACCATAAGAGATGTTGATCTGAAAGGCAAGAGAGTCATAATGAGAGTG GACTTCAACGTTCCAGTGAAGGATGGGGTCGTTCAGGACGACACGAGAATAAGAGCCGCC CTTCCAACGATAAAGTACGCTCTTGAACAGGGTGCAAAGGTGATACTCCTGTCCCATCTT GGAAGGCCCAAGGGAGAACCTTCACCAGAGTTCAGCCTCGCACCTGTCGCCAAAAGACTC TCTGAGCTTCTTGGAAAAGAAGTGAAGTTTGTTCCCGCTGTTGTCGGTGATGAGGTGAAA AAGGCCGTTGAGGAGCTCAAAGAGGGAGAGGTTCTCCTCCTTGAAAACACCAGATTCCAC CCGGGAGAGACCAAGAACGATCCTGAACTCGCGAAGTTCTGGGCTAGCCTCGCCGATATT CACGTGAACGATGCCTTCGGAACGGCGCACAGGGCACACGCTTCCAACGTTGGAATCGCA CAGTTTATTCCCAGCGTAGCGGGATTCCTCATGGAAAAAGAGATAAAGTTCCTTTCCAAG GTGACTTATAATCCAGAAAAACCGTACGTTGTGGTTCTTGGAGGAGCAAAGGTATCTGAC AAAATCGGCGTCATCACGAACCTCATGGAGAAAGCCGACAGAATTCTCATAGGTGGAGCC ATGATGTTCACCTTCCTGAAGGCTCTTGGCAAAGAGGTTGGATCGTCCAGGGTTGAAGAA GACAAGATCGACCTCGCAAAAGAACTCCTCGAAAAAGCGAAAGAAAAGGGTGTTGAGATC GTTCTTCCCGTTGATGCCGTTATCGCTCAGAAGATCGAACCCGGTGTGGAAAAGAAGGTT GTCAGAATCGACGACGGGATACCCGAAGGATGGATGGGCCTCGACATAGGACCCGAGACA ATTGAGCTCTTCAAGCAGAAGCTCTCCGATGCAAAAACCGTTGTCTGGAACGGGCCAATG GGAGTCTTCGAAATAGACGATTTCGCTGAAGGCACGAAGCAGGTCGCACTTGCGATCGCA GCGCTCACGGAAAAGGGAGCGATCACCGTTGTGGGTGGAGGAGACAGCGCCGCGGCGGTG AACAAGTTCGGTCTGGAAGACAAATTCTCCCACGTTTCAACGGGCGGAGGGGCTTCTCTC GAATTCCTTGAAGGAAAAGAACTTCCTGGTATTGCCAGCATCGCGGATAAAAAAAAAATA ACTCGTAAACTGATCCTCGCTGGGAACTGGAAGATGCATAAAACGATCTCGGAAGCGAAA AAGTTTGTGTCGCTGCTCGTGAACGAACTTCACGACGTGAAAGAGTTCGAAATAGTGGTC TGTCCTCCGTTCACAGCTCTATCTGAAGTGGGGGAAATACTCTCTGGTAGAAACATCAAA TTGGGAGCTCAAAACGTTTTCTACGAAGACCAGGGAGCGTTCACCGGGGAGATTTCTCCT CTCATGCTGCAAGAGATCGGCGTTGAATACGTGATCGTGGGACATTCCGAGAGAAGGCGT ATTTTCAAAGAAGACGACGAGTTCATAAACAGGAAAGTGAAAGCGGTGCTTGAAAAAGGT ATGACTCCTATTCTCTGCGTTGGAGAAACACTCGAGGAAAGAGAGAAAGGGCTCACTTTC TGCGTTGTGGAAAAACAGGTGAGAGAAGGTTTCTACGGTCTCGACAAAGAGGAAGCAAAG AGAGTGGTAATAGCTTACGAGCCAGTCTGGGCAATCGGGACAGGAAGGGTGGCGACACCA CAGCAGGCACAGGAAGTACACGCGTTCATAAGAAAGCTGCTCTCAGAGATGTACGACGAG GAAACAGCGGGATCGATAAGGATTCTCTACGGTGGAAGCATAAAGCCGGACAATTTCCTC GGTCTCATCGTTCAGAAGGATATAGATGGTGGTCTCGTTGGAGGAGCGAGTCTCAAAGAG TCTTTCATAGAACTTGCACGAATAATGAGAGGTGTGATTTCCTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P36204 UniProtKB Entry Name PGKT_THEMA GenBank Protein ID 450686 GenBank Gene ID X75437 - General References
- Schurig H, Beaucamp N, Ostendorp R, Jaenicke R, Adler E, Knowles JR: Phosphoglycerate kinase and triosephosphate isomerase from the hyperthermophilic bacterium Thermotoga maritima form a covalent bifunctional enzyme complex. EMBO J. 1995 Feb 1;14(3):442-51. [Article]
- Nelson KE, Clayton RA, Gill SR, Gwinn ML, Dodson RJ, Haft DH, Hickey EK, Peterson JD, Nelson WC, Ketchum KA, McDonald L, Utterback TR, Malek JA, Linher KD, Garrett MM, Stewart AM, Cotton MD, Pratt MS, Phillips CA, Richardson D, Heidelberg J, Sutton GG, Fleischmann RD, Eisen JA, White O, Salzberg SL, Smith HO, Venter JC, Fraser CM: Evidence for lateral gene transfer between Archaea and bacteria from genome sequence of Thermotoga maritima. Nature. 1999 May 27;399(6734):323-9. [Article]
- Auerbach G, Huber R, Grattinger M, Zaiss K, Schurig H, Jaenicke R, Jacob U: Closed structure of phosphoglycerate kinase from Thermotoga maritima reveals the catalytic mechanism and determinants of thermal stability. Structure. 1997 Nov 15;5(11):1475-83. [Article]
- Maes D, Zeelen JP, Thanki N, Beaucamp N, Alvarez M, Thi MH, Backmann J, Martial JA, Wyns L, Jaenicke R, Wierenga RK: The crystal structure of triosephosphate isomerase (TIM) from Thermotoga maritima: a comparative thermostability structural analysis of ten different TIM structures. Proteins. 1999 Nov 15;37(3):441-53. [Article]