Nicotinamide N-methyltransferase
Details
- Name
- Nicotinamide N-methyltransferase
- Synonyms
- 2.1.1.1
- Gene Name
- NNMT
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0010552|Nicotinamide N-methyltransferase MESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLI DIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPEAFDWSPVVTYVCDLEGN RVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRAL RNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQ SYSSTMANNEGLFSLVARKLSRPL
- Number of residues
- 264
- Molecular Weight
- 29573.705
- Theoretical pI
- 5.45
- GO Classification
- Functionsnicotinamide N-methyltransferase activityProcessesmethylation / organ regeneration / response to drug / response to organonitrogen compound / small molecule metabolic process / xenobiotic metabolic processComponentscytosol
- General Function
- Nicotinamide n-methyltransferase activity
- Specific Function
- Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.
- Pfam Domain Function
- NNMT_PNMT_TEMT (PF01234)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0010553|Nicotinamide N-methyltransferase (NNMT) ATGGAATCAGGCTTCACCTCCAAGGACACCTATCTAAGCCATTTTAACCCTCGGGATTAC CTAGAAAAATATTACAAGTTTGGTTCTAGGCACTCTGCAGAAAGCCAGATTCTTAAGCAC CTTCTGAAAAATCTTTTCAAGATATTCTGCCTAGACGGTGTGAAGGGAGACCTGCTGATT GACATCGGCTCTGGCCCCACTATCTATCAGCTCCTCTCTGCTTGTGAATCCTTTAAGGAG ATCGTCGTCACTGACTACTCAGACCAGAACCTGCAGGAGCTGGAGAAGTGGCTGAAGAAA GAGCCAGAGGCCTTTGACTGGTCCCCAGTGGTGACCTATGTGTGTGATCTTGAAGGGAAC AGAGTCAAGGGTCCAGAGAAGGAGGAGAAGTTGAGACAGGCGGTCAAGCAGGTGCTGAAG TGTGATGTGACTCAGAGCCAGCCACTGGGGGCCGTCCCCTTACCCCCGGCTGACTGCGTG CTCAGCACACTGTGTCTGGATGCCGCCTGCCCAGACCTCCCCACCTACTGCAGGGCGCTC AGGAACCTCGGCAGCCTACTGAAGCCAGGGGGCTTCCTGGTGATCATGGATGCGCTCAAG AGCAGCTACTACATGATTGGTGAGCAGAAGTTCTCCAGCCTCCCCCTGGGCCGGGAGGCA GTAGAGGCTGCTGTGAAAGAGGCTGGCTACACAATCGAATGGTTTGAGGTGATCTCGCAA AGTTATTCTTCCACCATGGCCAACAACGAAGGACTTTTCTCCCTGGTGGCGAGGAAGCTG AGCAGACCCCTGTGA
- Chromosome Location
- 11
- Locus
- 11q23.1
- External Identifiers
Resource Link UniProtKB ID P40261 UniProtKB Entry Name NNMT_HUMAN GenBank Protein ID 494989 GenBank Gene ID U08021 GenAtlas ID NNMT HGNC ID HGNC:7861 - General References
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