Bifunctional protein PyrR

Details

Name
Bifunctional protein PyrR
Synonyms
  • 2.4.2.9
  • UPRTase
Gene Name
pyrR
Organism
Bacillus caldolyticus
Amino acid sequence
>lcl|BSEQ0016504|Bifunctional protein PyrR
MQKAVVMDEQAIRRALTRIAHEIIERNKGIDGCVLVGIKTRGIYLARRLAERIEQIEGAS
VPVGELDITLYRDDLTVKTDDHEPLVKGTNVPFPVTERNVILVDDVLFTGRTVRAAMDAV
MDLGRPARIQLAVLVDRGHRELPIRADFVGKNVPTSRSELIVVELSEVDGIDQVSIHEK
Number of residues
179
Molecular Weight
19937.85
Theoretical pI
5.71
GO Classification
Functions
RNA binding / uracil phosphoribosyltransferase activity
Processes
DNA-templated transcription, termination / nucleoside metabolic process / regulation of transcription, DNA-templated
General Function
Uracil phosphoribosyltransferase activity
Specific Function
Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes (Probable).Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0003240|540 bp
ATGCAAAAGGCGGTCGTGATGGACGAACAGGCGATTCGCCGCGCTTTGACGCGCATCGCC
CACGAAATCATCGAACGAAACAAAGGCATTGACGGCTGCGTGCTTGTCGGAATTAAAACG
CGCGGCATTTACTTGGCGCGCCGCTTGGCGGAGCGGATCGAGCAAATTGAAGGGGCGTCC
GTTCCCGTCGGTGAGCTTGACATCACCTTGTACCGCGACGATTTGACCGTGAAGACGGAC
GACCATGAACCGCTTGTGAAAGGAACGAATGTGCCGTTTCCGGTGACCGAGCGGAATGTC
ATTTTAGTTGATGACGTGCTCTTCACCGGCCGGACGGTGCGGGCGGCGATGGATGCGGTC
ATGGATTTGGGCCGCCCGGCGCGCATCCAGCTCGCCGTGCTTGTTGACCGCGGCCACAGG
GAACTCCCGATCCGCGCTGATTTCGTCGGCAAAAACGTGCCGACCTCTCGTTCGGAACTG
ATCGTCGTGGAGCTTTCGGAAGTGGACGGCATCGATCAAGTCTCCATTCATGAAAAATAG
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP41007
UniProtKB Entry NamePYRR_BACCL
GenBank Protein ID431230
GenBank Gene IDX76083
General References
  1. Ghim SY, Neuhard J: The pyrimidine biosynthesis operon of the thermophile Bacillus caldolyticus includes genes for uracil phosphoribosyltransferase and uracil permease. J Bacteriol. 1994 Jun;176(12):3698-707. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01972Guanosine-5'-MonophosphateexperimentalunknownDetails
DB03315Guanosine 3'-monophosphateexperimentalunknownDetails
DB03685Uridine monophosphateexperimentalunknownDetails