Eukaryotic translation initiation factor 2 subunit 3
Details
- Name
- Eukaryotic translation initiation factor 2 subunit 3
- Synonyms
- eIF-2-gamma X
- eIF-2gX
- EIF2G
- Eukaryotic translation initiation factor 2 subunit gamma X
- Gene Name
- EIF2S3
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0021393|Eukaryotic translation initiation factor 2 subunit 3 MAGGEAGVTLGQPHLSRQDLTTLDVTKLTPLSHEVISRQATINIGTIGHVAHGKSTVVKA ISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGT KGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIM KLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIV KKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGI VSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGA VGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAV KADLGKIVLTNPVCTEVGEKIALSRRVEKHWRLIGWGQIRRGVTIKPTVDDD
- Number of residues
- 472
- Molecular Weight
- 51109.075
- Theoretical pI
- Not Available
- GO Classification
- FunctionsGTP binding / GTPase activity / translation factor activity, RNA binding / translation initiation factor activityProcessescellular protein metabolic process / formation of translation preinitiation complex / gene expression / translation / translational initiation / transmembrane transportComponentscytoplasm / cytosol / extracellular exosome
- General Function
- Translation initiation factor activity
- Specific Function
- eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0021394|Eukaryotic translation initiation factor 2 subunit 3 (EIF2S3) ATGGCGGGCGGAGAAGCTGGAGTGACTCTAGGGCAGCCGCATCTTTCGCGTCAGGATCTC ACCACCTTGGATGTTACCAAGTTGACGCCACTTTCACACGAAGTTATCAGCAGACAAGCC ACAATTAACATAGGTACAATTGGTCATGTAGCTCATGGGAAATCCACAGTCGTCAAAGCT ATTTCTGGAGTTCATACTGTCAGGTTCAAAAATGAACTAGAAAGAAATATTACAATCAAG CTTGGATATGCTAATGCTAAGATTTATAAGCTTGATGACCCAAGTTGCCCTCGGCCAGAA TGTTATAGATCTTGTGGGAGCAGTACACCTGACGAGTTTCCTACGGACATTCCAGGGACC AAAGGGAACTTCAAATTAGTCAGACATGTTTCCTTTGTTGACTGTCCTGGCCACGATATT TTGATGGCTACTATGCTGAACGGTGCAGCAGTGATGGATGCAGCTCTTCTGTTGATAGCT GGTAATGAATCTTGCCCTCAGCCTCAGACATCGGAACACCTGGCTGCTATAGAGATCATG AAACTGAAGCATATTTTGATTCTACAAAATAAAATTGATTTGGTAAAAGAAAGTCAGGCT AAAGAACAATACGAGCAGATCCTTGCATTTGTCCAAGGTACAGTAGCAGAGGGAGCTCCC ATTATTCCAATTTCAGCTCAGCTGAAATACAATATTGAAGTTGTTTGTGAGTACATAGTA AAGAAAATTCCAGTACCCCCAAGAGACTTTACTTCAGAGCCCCGGCTTATTGTTATTAGA TCTTTTGATGTCAACAAACCTGGCTGTGAAGTTGATGACCTTAAGGGAGGTGTAGCTGGT GGTAGTATCCTAAAAGGAGTATTAAAGGTGGGCCAGGAGATAGAAGTAAGACCTGGTATT GTTTCCAAAGATAGTGAAGGAAAACTCATGTGTAAACCAATCTTTTCCAAAATTGTATCA CTTTTTGCGGAGCATAATGATCTGCAATATGCTGCTCCAGGCGGTCTTATTGGAGTTGGA ACAAAAATTGACCCCACTTTGTGCCGGGCTGACAGAATGGTGGGGCAAGTACTTGGTGCA GTCGGAGCTTTACCTGAGATATTCACAGAATTGGAAATTTCCTATTTCCTGCTTAGACGG CTTCTAGGTGTACGCACTGAAGGAGACAAGAAAGCAGCAAAGGTTCAAAAGCTGTCTAAG AATGAAGTGCTCATGGTGAACATAGGATCCCTGTCAACAGGAGGGAGAGTTAGTGCTGTC AAGGCCGATTTGGGTAAAATTGTTTTGACCAATCCAGTGTGCACAGAGGTAGGAGAAAAA ATTGCCCTTAGCCGAAGAGTTGAAAAACACTGGCGTTTAATTGGTTGGGGTCAGATAAGA AGAGGAGTGACAATCAAGCCAACAGTAGATGATGACTGA
- Chromosome Location
- X
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P41091 UniProtKB Entry Name IF2G_HUMAN HGNC ID HGNC:3267 - General References
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