C-C chemokine receptor type 2

Details

Name
C-C chemokine receptor type 2
Synonyms
  • C-C CKR-2
  • CMKBR2
  • MCP-1-R
  • Monocyte chemoattractant protein 1 receptor
Gene Name
CCR2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0006609|C-C chemokine receptor type 2
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA
Number of residues
374
Molecular Weight
41914.265
Theoretical pI
9.25
GO Classification
Functions
C-C chemokine receptor activity / CCR2 chemokine receptor binding / chemokine receptor activity / protein homodimerization activity
Processes
blood vessel remodeling / cellular calcium ion homeostasis / cellular defense response / cellular homeostasis / chemokine-mediated signaling pathway / chemotaxis / cytokine-mediated signaling pathway / dendritic cell chemotaxis / immune response / inflammatory response / innate immune response / JAK-STAT cascade / negative regulation of adenylate cyclase activity / negative regulation of angiogenesis / negative regulation of eosinophil degranulation / negative regulation of type 2 immune response / positive regulation of alpha-beta T cell proliferation / positive regulation of astrocyte chemotaxis / positive regulation of CD8-positive, alpha-beta T cell extravasation / positive regulation of cytosolic calcium ion concentration / positive regulation of hematopoietic stem cell migration / positive regulation of immune complex clearance by monocytes and macrophages / positive regulation of inflammatory response / positive regulation of interferon-gamma production / positive regulation of interleukin-2 production / positive regulation of monocyte chemotaxis / positive regulation of monocyte extravasation / positive regulation of T cell activation / positive regulation of T cell chemotaxis / positive regulation of T-helper 1 type immune response / positive regulation of tumor necrosis factor biosynthetic process / regulation of vascular endothelial growth factor production / response to wounding / T-helper 17 cell chemotaxis / viral process
Components
cytoplasm / cytosol / dendrite / integral component of membrane / integral component of plasma membrane / neuronal cell body / perikaryon / perinuclear region of cytoplasm / plasma membrane
General Function
Protein homodimerization activity
Specific Function
Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection.
Pfam Domain Function
Transmembrane Regions
43-70 81-100 115-136 154-178 207-226 244-268 286-309
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0017084|C-C chemokine receptor type 2 (CCR2)
ATGCTGTCCACATCTCGTTCTCGGTTTATCAGAAATACCAACGAGAGCGGTGAAGAAGTC
ACCACCTTTTTTGATTATGATTACGGTGCTCCCTGTCATAAATTTGACGTGAAGCAAATT
GGGGCCCAACTCCTGCCTCCGCTCTACTCGCTGGTGTTCATCTTTGGTTTTGTGGGCAAC
ATGCTGGTCGTCCTCATCTTAATAAACTGCAAAAAGCTGAAGTGCTTGACTGACATTTAC
CTGCTCAACCTGGCCATCTCTGATCTGCTTTTTCTTATTACTCTCCCATTGTGGGCTCAC
TCTGCTGCAAATGAGTGGGTCTTTGGGAATGCAATGTGCAAATTATTCACAGGGCTGTAT
CACATCGGTTATTTTGGCGGAATCTTCTTCATCATCCTCCTGACAATCGATAGATACCTG
GCTATTGTCCATGCTGTGTTTGCTTTAAAAGCCAGGACGGTCACCTTTGGGGTGGTGACA
AGTGTGATCACCTGGTTGGTGGCTGTGTTTGCTTCTGTCCCAGGAATCATCTTTACTAAA
TGCCAGAAAGAAGATTCTGTTTATGTCTGTGGCCCTTATTTTCCACGAGGATGGAATAAT
TTCCACACAATAATGAGGAACATTTTGGGGCTGGTCCTGCCGCTGCTCATCATGGTCATC
TGCTACTCGGGAATCCTGAAAACCCTGCTTCGGTGTCGAAACGAGAAGAAGAGGCATAGG
GCAGTGAGAGTCATCTTCACCATCATGATTGTTTACTTTCTCTTCTGGACTCCCTATAAT
ATTGTCATTCTCCTGAACACCTTCCAGGAATTCTTCGGCCTGAGTAACTGTGAAAGCACC
AGTCAACTGGACCAAGCCACGCAGGTGACAGAGACTCTTGGGATGACTCACTGCTGCATC
AATCCCATCATCTATGCCTTCGTTGGGGAGAAGTTCAGAAGCCTTTTTCACATAGCTCTT
GGCTGTAGGATTGCCCCACTCCAAAAACCAGTGTGTGGAGGTCCAGGAGTGAGACCAGGA
AAGAATGTGAAAGTGACTACACAAGGACTCCTCGATGGTCGTGGAAAAGGAAAGTCAATT
GGCAGAGCCCCTGAAGCCAGTCTTCAGGACAAAGAAGGAGCCTAG
Chromosome Location
3
Locus
3p21.31
External Identifiers
ResourceLink
UniProtKB IDP41597
UniProtKB Entry NameCCR2_HUMAN
GenBank Gene IDU03882
GenAtlas IDCCR2
HGNC IDHGNC:1603
General References
  1. Charo IF, Myers SJ, Herman A, Franci C, Connolly AJ, Coughlin SR: Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2752-6. [Article]
  2. Yamagami S, Tokuda Y, Ishii K, Tanaka H, Endo N: cDNA cloning and functional expression of a human monocyte chemoattractant protein 1 receptor. Biochem Biophys Res Commun. 1994 Jul 29;202(2):1156-62. [Article]
  3. Wong LM, Myers SJ, Tsou CL, Gosling J, Arai H, Charo IF: Organization and differential expression of the human monocyte chemoattractant protein 1 receptor gene. Evidence for the role of the carboxyl-terminal tail in receptor trafficking. J Biol Chem. 1997 Jan 10;272(2):1038-45. [Article]
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  7. Mellado M, Rodriguez-Frade JM, Aragay A, del Real G, Martin AM, Vila-Coro AJ, Serrano A, Mayor F Jr, Martinez-A C: The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor. J Immunol. 1998 Jul 15;161(2):805-13. [Article]
  8. Aragay AM, Mellado M, Frade JM, Martin AM, Jimenez-Sainz MC, Martinez-A C, Mayor F Jr: Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):2985-90. [Article]
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  11. Sung HJ, Kim YS, Kang H, Ko J: Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration. Exp Mol Med. 2008 Jun 30;40(3):332-8. [Article]
  12. Tan JH, Ludeman JP, Wedderburn J, Canals M, Hall P, Butler SJ, Taleski D, Christopoulos A, Hickey MJ, Payne RJ, Stone MJ: Tyrosine sulfation of chemokine receptor CCR2 enhances interactions with both monomeric and dimeric forms of the chemokine monocyte chemoattractant protein-1 (MCP-1). J Biol Chem. 2013 Apr 5;288(14):10024-34. doi: 10.1074/jbc.M112.447359. Epub 2013 Feb 13. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB05130INCB3284investigationalunknownDetails
DB05159CCX915investigationalunknownDetails
DB12520PlozalizumabinvestigationalunknownDetails
DB11758CenicrivirocinvestigationalunknowninhibitorDetails