Megakaryocyte-associated tyrosine-protein kinase
Details
- Name
- Megakaryocyte-associated tyrosine-protein kinase
- Synonyms
- 2.7.10.2
- CHK
- CSK homologous kinase
- CTK
- Hematopoietic consensus tyrosine-lacking kinase
- HYL
- Protein kinase HYL
- Tyrosine-protein kinase CTK
- Gene Name
- MATK
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0051848|Megakaryocyte-associated tyrosine-protein kinase MAGRGSLVSWRAFHGCDSAEELPRVSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCEHT RPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLM PWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTI DEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQ IGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQGL YIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILV SEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSY GRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLAR ELRSAGAPASVSGQDADGSTSPRSQEP
- Number of residues
- 507
- Molecular Weight
- 56468.51
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / non-membrane spanning protein tyrosine kinase activity / protein tyrosine kinase activity / receptor bindingProcessescell differentiation / cell proliferation / ERBB2 signaling pathway / innate immune response / mesoderm development / peptidyl-tyrosine autophosphorylation / positive regulation of cell proliferation / protein phosphorylation / transmembrane receptor protein tyrosine kinase signaling pathwayComponentscytosol / extrinsic component of cytoplasmic side of plasma membrane
- General Function
- Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.
- Specific Function
- Atp binding
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0051849|Megakaryocyte-associated tyrosine-protein kinase (MATK) ATGGCGGGGCGAGGCTCTCTGGTTTCCTGGCGGGCATTTCACGGCTGTGATTCTGCTGAG GAACTTCCCCGGGTGAGCCCCCGCTTCCTCCGAGCCTGGCACCCCCCTCCCGTCTCAGCC AGGATGCCAACGAGGCGCTGGGCCCCGGGCACCCAGTGTATCACCAAATGCGAGCACACC CGCCCCAAGCCAGGGGAGCTGGCCTTCCGCAAGGGCGACGTGGTCACCATCCTGGAGGCC TGCGAGAACAAGAGCTGGTACCGCGTCAAGCACCACACCAGTGGACAGGAGGGGCTGCTG GCAGCTGGGGCGCTGCGGGAGCGGGAGGCCCTCTCCGCAGACCCCAAGCTCAGCCTCATG CCGTGGTTCCACGGGAAGATCTCGGGCCAGGAGGCTGTCCAGCAGCTGCAGCCTCCCGAG GATGGGCTGTTCCTGGTGCGGGAGTCCGCGCGCCACCCCGGCGACTACGTCCTGTGCGTG AGCTTTGGCCGCGACGTCATCCACTACCGCGTGCTGCACCGCGACGGCCACCTCACAATC GATGAGGCCGTGTTCTTCTGCAACCTCATGGACATGGTGGAGCATTACAGCAAGGACAAG GGCGCTATCTGCACCAAGCTGGTGAGACCAAAGCGGAAACACGGGACCAAGTCGGCCGAG GAGGAGCTGGCCAGGGCGGGCTGGTTACTGAACCTGCAGCATTTGACATTGGGAGCACAG ATCGGAGAGGGAGAGTTTGGAGCTGTCCTGCAGGGTGAGTACCTGGGGCAAAAGGTGGCC GTGAAGAATATCAAGTGTGATGTGACAGCCCAGGCCTTCCTGGACGAGACGGCCGTCATG ACGAAGATGCAACACGAGAACCTGGTGCGTCTCCTGGGCGTGATCCTGCACCAGGGGCTG TACATTGTCATGGAGCACGTGAGCAAGGGCAACCTGGTGAACTTTCTGCGGACCCGGGGT CGAGCCCTCGTGAACACCGCTCAGCTCCTGCAGTTTTCTCTGCACGTGGCCGAGGGCATG GAGTACCTGGAGAGCAAGAAGCTTGTGCACCGCGACCTGGCCGCCCGCAACATCCTGGTC TCAGAGGACCTGGTGGCCAAGGTCAGCGACTTTGGCCTGGCCAAAGCCGAGCGGAAGGGG CTAGACTCAAGCCGGCTGCCCGTCAAGTGGACGGCGCCCGAGGCTCTCAAACACGGGAAG TTCACCAGCAAGTCGGATGTCTGGAGTTTTGGGGTGCTGCTCTGGGAGGTCTTCTCATAT GGACGGGCTCCGTACCCTAAAATGTCACTGAAAGAGGTGTCGGAGGCCGTGGAGAAGGGG TACCGCATGGAACCCCCCGAGGGCTGTCCAGGCCCCGTGCACGTCCTCATGAGCAGCTGC TGGGAGGCAGAGCCCGCCCGCCGGCCACCCTTCCGCAAACTGGCCGAGAAGCTGGCCCGG GAGCTACGCAGTGCAGGTGCCCCAGCCTCCGTCTCAGGGCAGGACGCCGACGGCTCCACC TCGCCCCGAAGCCAGGAGCCCTGA
- Chromosome Location
- 19
- Locus
- 19p13.3
- External Identifiers
Resource Link UniProtKB ID P42679 UniProtKB Entry Name MATK_HUMAN HGNC ID HGNC:6906 - General References
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