Proliferation marker protein Ki-67

Details

Name

Proliferation marker protein Ki-67

Synonyms

• Antigen identified by monoclonal antibody Ki-67
• Antigen KI-67
• Antigen Ki67

Gene Name

MKI67

Organism

Humans

Amino acid sequence

>lcl|BSEQ0052643|Proliferation marker protein Ki-67
MWPTRRLVTIKRSGVDGPHFPLSLSTCLFGRGIECDIRIQLPVVSKQHCKIEIHEQEAIL
HNFSSTNPTQVNGSVIDEPVRLKHGDVITIIDRSFRYENESLQNGRKSTEFPRKIREQEP
ARRVSRSSFSSDPDEKAQDSKAYSKITEGKVSGNPQVHIKNVKEDSTADDSKDSVAQGTT
NVHSSEHAGRNGRNAADPISGDFKEISSVKLVSRYGELKSVPTTQCLDNSKKNESPFWKL
YESVKKELDVKSQKENVLQYCRKSGLQTDYATEKESADGLQGETQLLVSRKSRPKSGGSG
HAVAEPASPEQELDQNKGKGRDVESVQTPSKAVGASFPLYEPAKMKTPVQYSQQQNSPQK
HKNKDLYTTGRRESVNLGKSEGFKAGDKTLTPRKLSTRNRTPAKVEDAADSATKPENLSS
KTRGSIPTDVEVLPTETEIHNEPFLTLWLTQVERKIQKDSLSKPEKLGTTAGQMCSGLPG
LSSVDINNFGDSINESEGIPLKRRRVSFGGHLRPELFDENLPPNTPLKRGEAPTKRKSLV
MHTPPVLKKIIKEQPQPSGKQESGSEIHVEVKAQSLVISPPAPSPRKTPVASDQRRRSCK
TAPASSSKSQTEVPKRGGRKSGNLPSKRVSISRSQHDILQMICSKRRSGASEANLIVAKS
WADVVKLGAKQTQTKVIKHGPQRSMNKRQRRPATPKKPVGEVHSQFSTGHANSPCTIIIG
KAHTEKVHVPARPYRVLNNFISNQKMDFKEDLSGIAEMFKTPVKEQPQLTSTCHIAISNS
ENLLGKQFQGTDSGEEPLLPTSESFGGNVFFSAQNAAKQPSDKCSASPPLRRQCIRENGN
VAKTPRNTYKMTSLETKTSDTETEPSKTVSTANRSGRSTEFRNIQKLPVESKSEETNTEI
VECILKRGQKATLLQQRREGEMKEIERPFETYKENIELKENDEKMKAMKRSRTWGQKCAP
MSDLTDLKSLPDTELMKDTARGQNLLQTQDHAKAPKSEKGKITKMPCQSLQPEPINTPTH
TKQQLKASLGKVGVKEELLAVGKFTRTSGETTHTHREPAGDGKSIRTFKESPKQILDPAA
RVTGMKKWPRTPKEEAQSLEDLAGFKELFQTPGPSEESMTDEKTTKIACKSPPPESVDTP
TSTKQWPKRSLRKADVEEEFLALRKLTPSAGKAMLTPKPAGGDEKDIKAFMGTPVQKLDL
AGTLPGSKRQLQTPKEKAQALEDLAGFKELFQTPGHTEELVAAGKTTKIPCDSPQSDPVD
TPTSTKQRPKRSIRKADVEGELLACRNLMPSAGKAMHTPKPSVGEEKDIIIFVGTPVQKL
DLTENLTGSKRRPQTPKEEAQALEDLTGFKELFQTPGHTEEAVAAGKTTKMPCESSPPES
ADTPTSTRRQPKTPLEKRDVQKELSALKKLTQTSGETTHTDKVPGGEDKSINAFRETAKQ
KLDPAASVTGSKRHPKTKEKAQPLEDLAGLKELFQTPVCTDKPTTHEKTTKIACRSQPDP
VDTPTSSKPQSKRSLRKVDVEEEFFALRKRTPSAGKAMHTPKPAVSGEKNIYAFMGTPVQ
KLDLTENLTGSKRRLQTPKEKAQALEDLAGFKELFQTRGHTEESMTNDKTAKVACKSSQP
DPDKNPASSKRRLKTSLGKVGVKEELLAVGKLTQTSGETTHTHTEPTGDGKSMKAFMESP
KQILDSAASLTGSKRQLRTPKGKSEVPEDLAGFIELFQTPSHTKESMTNEKTTKVSYRAS
QPDLVDTPTSSKPQPKRSLRKADTEEEFLAFRKQTPSAGKAMHTPKPAVGEEKDINTFLG
TPVQKLDQPGNLPGSNRRLQTRKEKAQALEELTGFRELFQTPCTDNPTTDEKTTKKILCK
SPQSDPADTPTNTKQRPKRSLKKADVEEEFLAFRKLTPSAGKAMHTPKAAVGEEKDINTF
VGTPVEKLDLLGNLPGSKRRPQTPKEKAKALEDLAGFKELFQTPGHTEESMTDDKITEVS
CKSPQPDPVKTPTSSKQRLKISLGKVGVKEEVLPVGKLTQTSGKTTQTHRETAGDGKSIK
AFKESAKQMLDPANYGTGMERWPRTPKEEAQSLEDLAGFKELFQTPDHTEESTTDDKTTK
IACKSPPPESMDTPTSTRRRPKTPLGKRDIVEELSALKQLTQTTHTDKVPGDEDKGINVF
RETAKQKLDPAASVTGSKRQPRTPKGKAQPLEDLAGLKELFQTPICTDKPTTHEKTTKIA
CRSPQPDPVGTPTIFKPQSKRSLRKADVEEESLALRKRTPSVGKAMDTPKPAGGDEKDMK
AFMGTPVQKLDLPGNLPGSKRWPQTPKEKAQALEDLAGFKELFQTPGTDKPTTDEKTTKI
ACKSPQPDPVDTPASTKQRPKRNLRKADVEEEFLALRKRTPSAGKAMDTPKPAVSDEKNI
NTFVETPVQKLDLLGNLPGSKRQPQTPKEKAEALEDLVGFKELFQTPGHTEESMTDDKIT
EVSCKSPQPESFKTSRSSKQRLKIPLVKVDMKEEPLAVSKLTRTSGETTQTHTEPTGDSK
SIKAFKESPKQILDPAASVTGSRRQLRTRKEKARALEDLVDFKELFSAPGHTEESMTIDK
NTKIPCKSPPPELTDTATSTKRCPKTRPRKEVKEELSAVERLTQTSGQSTHTHKEPASGD
EGIKVLKQRAKKKPNPVEEEPSRRRPRAPKEKAQPLEDLAGFTELSETSGHTQESLTAGK
ATKIPCESPPLEVVDTTASTKRHLRTRVQKVQVKEEPSAVKFTQTSGETTDADKEPAGED
KGIKALKESAKQTPAPAASVTGSRRRPRAPRESAQAIEDLAGFKDPAAGHTEESMTDDKT
TKIPCKSSPELEDTATSSKRRPRTRAQKVEVKEELLAVGKLTQTSGETTHTDKEPVGEGK
GTKAFKQPAKRKLDAEDVIGSRRQPRAPKEKAQPLEDLASFQELSQTPGHTEELANGAAD
SFTSAPKQTPDSGKPLKISRRVLRAPKVEPVGDVVSTRDPVKSQSKSNTSLPPLPFKRGG
GKDGSVTGTKRLRCMPAPEEIVEELPASKKQRVAPRARGKSSEPVVIMKRSLRTSAKRIE
PAEELNSNDMKTNKEEHKLQDSVPENKGISLRSRRQNKTEAEQQITEVFVLAERIEINRN
EKKPMKTSPEMDIQNPDDGARKPIPRDKVTENKRCLRSARQNESSQPKVAEESGGQKSAK
VLMQNQKGKGEAGNSDSMCLRSRKTKSQPAASTLESKSVQRVTRSVKRCAENPKKAEDNV
CVKKIRTRSHRDSEDI

Number of residues

3256

Molecular Weight

358690.975

Theoretical pI

Not Available

GO Classification

Functions

ATP binding / DNA binding / protein C-terminus binding / RNA binding

Processes

cell cycle / cell population proliferation / regulation of chromatin organization / regulation of chromosome segregation / regulation of mitotic nuclear division

Components

chromosome / membrane / nuclear body / nucleolus / nucleoplasm / nucleus

General Function

Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).

Specific Function

Atp binding

Pfam Domain Function

• FHA (PF00498)
• KI67R (PF08065)
• PP1_bind (PF15276)

Transmembrane Regions

Not Available

Cellular Location

Chromosome

Gene sequence

>lcl|BSEQ0052644|Proliferation marker protein Ki-67 (MKI67)
ATGTGGCCCACGAGACGCCTGGTTACTATCAAAAGGAGCGGGGTCGACGGTCCCCACTTT
CCCCTGAGCCTCAGCACCTGCTTGTTTGGAAGGGGTATTGAATGTGACATCCGTATCCAG
CTTCCTGTTGTGTCAAAACAACATTGCAAAATTGAAATCCATGAGCAGGAGGCAATATTA
CATAATTTCAGTTCCACAAATCCAACACAAGTAAATGGGTCTGTTATTGATGAGCCTGTA
CGGCTAAAACATGGAGATGTAATAACTATTATTGATCGTTCCTTCAGGTATGAAAATGAA
AGTCTTCAGAATGGAAGGAAGTCAACTGAATTTCCAAGAAAAATACGTGAACAGGAGCCA
GCACGTCGTGTCTCAAGATCTAGCTTCTCTTCTGACCCTGATGAGAAAGCTCAAGATTCC
AAGGCCTATTCAAAAATCACTGAAGGAAAAGTTTCAGGAAATCCTCAGGTACATATCAAG
AATGTCAAAGAAGACAGTACCGCAGATGACTCAAAAGACAGTGTTGCTCAGGGAACAACT
AATGTTCATTCCTCAGAACATGCTGGACGTAATGGCAGAAATGCAGCTGATCCCATTTCT
GGGGATTTTAAAGAAATTTCCAGCGTTAAATTAGTGAGCCGTTATGGAGAATTGAAGTCT
GTTCCCACTACACAATGTCTTGACAATAGCAAAAAAAATGAATCTCCCTTTTGGAAGCTT
TATGAGTCAGTGAAGAAAGAGTTGGATGTAAAATCACAAAAAGAAAATGTCCTACAGTAT
TGTAGAAAATCTGGATTACAAACTGATTACGCAACAGAGAAAGAAAGTGCTGATGGTTTA
CAGGGGGAGACCCAACTGTTGGTCTCGCGTAAGTCAAGACCAAAATCTGGTGGGAGCGGC
CACGCTGTGGCAGAGCCTGCTTCACCTGAACAAGAGCTTGACCAGAACAAGGGGAAGGGA
AGAGACGTGGAGTCTGTTCAGACTCCCAGCAAGGCTGTGGGCGCCAGCTTTCCTCTCTAT
GAGCCGGCTAAAATGAAGACCCCTGTACAATATTCACAGCAACAAAATTCTCCACAAAAA
CATAAGAACAAAGACCTGTATACTACTGGTAGAAGAGAATCTGTGAATCTGGGTAAAAGT
GAAGGCTTCAAGGCTGGTGATAAAACTCTTACTCCCAGGAAGCTTTCAACTAGAAATCGA
ACACCAGCTAAAGTTGAAGATGCAGCTGACTCTGCCACTAAGCCAGAAAATCTCTCTTCC
AAAACCAGAGGAAGTATTCCTACAGATGTGGAAGTTCTGCCTACGGAAACTGAAATTCAC
AATGAGCCATTTTTAACTCTGTGGCTCACTCAAGTTGAGAGGAAGATCCAAAAGGATTCC
CTCAGCAAGCCTGAGAAATTGGGCACTACAGCTGGACAGATGTGCTCTGGGTTACCTGGT
CTTAGTTCAGTTGATATCAACAACTTTGGTGATTCCATTAATGAGAGTGAGGGAATACCT
TTGAAAAGAAGGCGTGTGTCCTTTGGTGGGCACCTAAGACCTGAACTATTTGATGAAAAC
TTGCCTCCTAATACGCCTCTCAAAAGGGGAGAAGCCCCAACCAAAAGAAAGTCTCTGGTA
ATGCACACTCCACCTGTCCTGAAGAAAATCATCAAGGAACAGCCTCAACCATCAGGAAAA
CAAGAGTCAGGTTCAGAAATCCATGTGGAAGTGAAGGCACAAAGCTTGGTTATAAGCCCT
CCAGCTCCTAGTCCTAGGAAAACTCCAGTTGCCAGTGATCAACGCCGTAGGTCCTGCAAA
ACAGCCCCTGCTTCCAGCAGCAAATCTCAGACAGAGGTTCCTAAGAGAGGAGGGAGAAAG
AGTGGCAACCTGCCTTCAAAGAGAGTGTCTATCAGCCGAAGTCAACATGATATTTTACAG
ATGATATGTTCCAAAAGAAGAAGTGGTGCTTCGGAAGCAAATCTGATTGTTGCAAAATCA
TGGGCAGATGTAGTAAAACTTGGTGCAAAACAAACACAAACTAAAGTCATAAAACATGGT
CCTCAAAGGTCAATGAACAAAAGGCAAAGAAGACCTGCTACTCCAAAGAAGCCTGTGGGC
GAAGTTCACAGTCAATTTAGTACAGGCCACGCAAACTCTCCTTGTACCATAATAATAGGG
AAAGCTCATACTGAAAAAGTACATGTGCCTGCTCGACCCTACAGAGTGCTCAACAACTTC
ATTTCCAACCAAAAAATGGACTTTAAGGAAGATCTTTCAGGAATAGCTGAAATGTTCAAG
ACCCCAGTGAAGGAGCAACCGCAGTTGACAAGCACATGTCACATCGCTATTTCAAATTCA
GAGAATTTGCTTGGAAAACAGTTTCAAGGAACTGATTCAGGAGAAGAACCTCTGCTCCCC
ACCTCAGAGAGTTTTGGAGGAAATGTGTTCTTCAGTGCACAGAATGCAGCAAAACAGCCA
TCTGATAAATGCTCTGCAAGCCCTCCCTTAAGACGGCAGTGTATTAGAGAAAATGGAAAC
GTAGCAAAAACGCCCAGGAACACCTACAAAATGACTTCTCTGGAGACAAAAACTTCAGAT
ACTGAGACAGAGCCTTCAAAAACAGTATCCACTGCAAACAGGTCAGGAAGGTCTACAGAG
TTCAGGAATATACAGAAGCTACCTGTGGAAAGTAAGAGTGAAGAAACAAATACAGAAATT
GTTGAGTGCATCCTAAAAAGAGGTCAGAAGGCAACACTACTACAACAAAGGAGAGAAGGA
GAGATGAAGGAAATAGAAAGACCTTTTGAGACATATAAGGAAAATATTGAATTAAAAGAA
AACGATGAAAAGATGAAAGCAATGAAGAGATCAAGAACTTGGGGGCAGAAATGTGCACCA
ATGTCTGACCTGACAGACCTCAAGAGCTTGCCTGATACAGAACTCATGAAAGACACGGCA
CGTGGCCAGAATCTCCTCCAAACCCAAGATCATGCCAAGGCACCAAAGAGTGAGAAAGGC
AAAATCACTAAAATGCCCTGCCAGTCATTACAACCAGAACCAATAAACACCCCAACACAC
ACAAAACAACAGTTGAAGGCATCCCTGGGGAAAGTAGGTGTGAAAGAAGAGCTCCTAGCA
GTCGGCAAGTTCACACGGACGTCAGGGGAGACCACGCACACGCACAGAGAGCCAGCAGGA
GATGGCAAGAGCATCAGAACGTTTAAGGAGTCTCCAAAGCAGATCCTGGACCCAGCAGCC
CGTGTAACTGGAATGAAGAAGTGGCCAAGAACGCCTAAGGAAGAGGCCCAGTCACTAGAA
GACCTGGCTGGCTTCAAAGAGCTCTTCCAGACACCAGGTCCCTCTGAGGAATCAATGACT
GATGAGAAAACTACCAAAATAGCCTGCAAATCTCCACCACCAGAATCAGTGGACACTCCA
ACAAGCACAAAGCAATGGCCTAAGAGAAGTCTCAGGAAAGCAGATGTAGAGGAAGAATTC
TTAGCACTCAGGAAACTAACACCATCAGCAGGGAAAGCCATGCTTACGCCCAAACCAGCA
GGAGGTGATGAGAAAGACATTAAAGCATTTATGGGAACTCCAGTGCAGAAACTGGACCTG
GCAGGAACTTTACCTGGCAGCAAAAGACAGCTACAGACTCCTAAGGAAAAGGCCCAGGCT
CTAGAAGACCTGGCTGGCTTTAAAGAGCTCTTCCAGACTCCTGGTCACACCGAGGAATTA
GTGGCTGCTGGTAAAACCACTAAAATACCCTGCGACTCTCCACAGTCAGACCCAGTGGAC
ACCCCAACAAGCACAAAGCAACGACCCAAGAGAAGTATCAGGAAAGCAGATGTAGAGGGA
GAACTCTTAGCGTGCAGGAATCTAATGCCATCAGCAGGCAAAGCCATGCACACGCCTAAA
CCATCAGTAGGTGAAGAGAAAGACATCATCATATTTGTGGGAACTCCAGTGCAGAAACTG
GACCTGACAGAGAACTTAACCGGCAGCAAGAGACGGCCACAAACTCCTAAGGAAGAGGCC
CAGGCTCTGGAAGACCTGACTGGCTTTAAAGAGCTCTTCCAGACCCCTGGTCATACTGAA
GAAGCAGTGGCTGCTGGCAAAACTACTAAAATGCCCTGCGAATCTTCTCCACCAGAATCA
GCAGACACCCCAACAAGCACAAGAAGGCAGCCCAAGACACCTTTGGAGAAAAGGGACGTA
CAGAAGGAGCTCTCAGCCCTGAAGAAGCTCACACAGACATCAGGGGAAACCACACACACA
GATAAAGTACCAGGAGGTGAGGATAAAAGCATCAACGCGTTTAGGGAAACTGCAAAACAG
AAACTGGACCCAGCAGCAAGTGTAACTGGTAGCAAGAGGCACCCAAAAACTAAGGAAAAG
GCCCAACCCCTAGAAGACCTGGCTGGCTTGAAAGAGCTCTTCCAGACACCAGTATGCACT
GACAAGCCCACGACTCACGAGAAAACTACCAAAATAGCCTGCAGATCACAACCAGACCCA
GTGGACACACCAACAAGCTCCAAGCCACAGTCCAAGAGAAGTCTCAGGAAAGTGGACGTA
GAAGAAGAATTCTTCGCACTCAGGAAACGAACACCATCAGCAGGCAAAGCCATGCACACA
CCCAAACCAGCAGTAAGTGGTGAGAAAAACATCTACGCATTTATGGGAACTCCAGTGCAG
AAACTGGACCTGACAGAGAACTTAACTGGCAGCAAGAGACGGCTACAAACTCCTAAGGAA
AAGGCCCAGGCTCTAGAAGACCTGGCTGGCTTTAAAGAGCTCTTCCAGACACGAGGTCAC
ACTGAGGAATCAATGACTAACGATAAAACTGCCAAAGTAGCCTGCAAATCTTCACAACCA
GACCCAGACAAAAACCCAGCAAGCTCCAAGCGACGGCTCAAGACATCCCTGGGGAAAGTG
GGCGTGAAAGAAGAGCTCCTAGCAGTTGGCAAGCTCACACAGACATCAGGAGAGACTACA
CACACACACACAGAGCCAACAGGAGATGGTAAGAGCATGAAAGCATTTATGGAGTCTCCA
AAGCAGATCTTAGACTCAGCAGCAAGTCTAACTGGCAGCAAGAGGCAGCTGAGAACTCCT
AAGGGAAAGTCTGAAGTCCCTGAAGACCTGGCCGGCTTCATCGAGCTCTTCCAGACACCA
AGTCACACTAAGGAATCAATGACTAACGAAAAAACTACCAAAGTATCCTACAGAGCTTCA
CAGCCAGACCTAGTGGACACCCCAACAAGCTCCAAGCCACAGCCCAAGAGAAGTCTCAGG
AAAGCAGACACTGAAGAAGAATTTTTAGCATTTAGGAAACAAACGCCATCAGCAGGCAAA
GCCATGCACACACCCAAACCAGCAGTAGGTGAAGAGAAAGACATCAACACGTTTTTGGGA
ACTCCAGTGCAGAAACTGGACCAGCCAGGAAATTTACCTGGCAGCAATAGACGGCTACAA
ACTCGTAAGGAAAAGGCCCAGGCTCTAGAAGAACTGACTGGCTTCAGAGAGCTTTTCCAG
ACACCATGCACTGATAACCCCACGACTGATGAGAAAACTACCAAAAAAATACTCTGCAAA
TCTCCGCAATCAGACCCAGCGGACACCCCAACAAACACAAAGCAACGGCCCAAGAGAAGC
CTCAAGAAAGCAGACGTAGAGGAAGAATTTTTAGCATTCAGGAAACTAACACCATCAGCA
GGCAAAGCCATGCACACGCCTAAAGCAGCAGTAGGTGAAGAGAAAGACATCAACACATTT
GTGGGGACTCCAGTGGAGAAACTGGACCTGCTAGGAAATTTACCTGGCAGCAAGAGACGG
CCACAAACTCCTAAAGAAAAGGCCAAGGCTCTAGAAGATCTGGCTGGCTTCAAAGAGCTC
TTCCAGACACCAGGTCACACTGAGGAATCAATGACCGATGACAAAATCACAGAAGTATCC
TGCAAATCTCCACAACCAGACCCAGTCAAAACCCCAACAAGCTCCAAGCAACGACTCAAG
ATATCCTTGGGGAAAGTAGGTGTGAAAGAAGAGGTCCTACCAGTCGGCAAGCTCACACAG
ACGTCAGGGAAGACCACACAGACACACAGAGAGACAGCAGGAGATGGAAAGAGCATCAAA
GCGTTTAAGGAATCTGCAAAGCAGATGCTGGACCCAGCAAACTATGGAACTGGGATGGAG
AGGTGGCCAAGAACACCTAAGGAAGAGGCCCAATCACTAGAAGACCTGGCCGGCTTCAAA
GAGCTCTTCCAGACACCAGACCACACTGAGGAATCAACAACTGATGACAAAACTACCAAA
ATAGCCTGCAAATCTCCACCACCAGAATCAATGGACACTCCAACAAGCACAAGGAGGCGG
CCCAAAACACCTTTGGGGAAAAGGGATATAGTGGAAGAGCTCTCAGCCCTGAAGCAGCTC
ACACAGACCACACACACAGACAAAGTACCAGGAGATGAGGATAAAGGCATCAACGTGTTC
AGGGAAACTGCAAAACAGAAACTGGACCCAGCAGCAAGTGTAACTGGTAGCAAGAGGCAG
CCAAGAACTCCTAAGGGAAAAGCCCAACCCCTAGAAGACTTGGCTGGCTTGAAAGAGCTC
TTCCAGACACCAATATGCACTGACAAGCCCACGACTCATGAGAAAACTACCAAAATAGCC
TGCAGATCTCCACAACCAGACCCAGTGGGTACCCCAACAATCTTCAAGCCACAGTCCAAG
AGAAGTCTCAGGAAAGCAGACGTAGAGGAAGAATCCTTAGCACTCAGGAAACGAACACCA
TCAGTAGGGAAAGCTATGGACACACCCAAACCAGCAGGAGGTGATGAGAAAGACATGAAA
GCATTTATGGGAACTCCAGTGCAGAAATTGGACCTGCCAGGAAATTTACCTGGCAGCAAA
AGATGGCCACAAACTCCTAAGGAAAAGGCCCAGGCTCTAGAAGACCTGGCTGGCTTCAAA
GAGCTCTTCCAGACACCAGGCACTGACAAGCCCACGACTGATGAGAAAACTACCAAAATA
GCCTGCAAATCTCCACAACCAGACCCAGTGGACACCCCAGCAAGCACAAAGCAACGGCCC
AAGAGAAACCTCAGGAAAGCAGACGTAGAGGAAGAATTTTTAGCACTCAGGAAACGAACA
CCATCAGCAGGCAAAGCCATGGACACACCAAAACCAGCAGTAAGTGATGAGAAAAATATC
AACACATTTGTGGAAACTCCAGTGCAGAAACTGGACCTGCTAGGAAATTTACCTGGCAGC
AAGAGACAGCCACAGACTCCTAAGGAAAAGGCTGAGGCTCTAGAGGACCTGGTTGGCTTC
AAAGAACTCTTCCAGACACCAGGTCACACTGAGGAATCAATGACTGATGACAAAATCACA
GAAGTATCCTGTAAATCTCCACAGCCAGAGTCATTCAAAACCTCAAGAAGCTCCAAGCAA
AGGCTCAAGATACCCCTGGTGAAAGTGGACATGAAAGAAGAGCCCCTAGCAGTCAGCAAG
CTCACACGGACATCAGGGGAGACTACGCAAACACACACAGAGCCAACAGGAGATAGTAAG
AGCATCAAAGCGTTTAAGGAGTCTCCAAAGCAGATCCTGGACCCAGCAGCAAGTGTAACT
GGTAGCAGGAGGCAGCTGAGAACTCGTAAGGAAAAGGCCCGTGCTCTAGAAGACCTGGTT
GACTTCAAAGAGCTCTTCTCAGCACCAGGTCACACTGAAGAGTCAATGACTATTGACAAA
AACACAAAAATTCCCTGCAAATCTCCCCCACCAGAACTAACAGACACTGCCACGAGCACA
AAGAGATGCCCCAAGACACGTCCCAGGAAAGAAGTAAAAGAGGAGCTCTCAGCAGTTGAG
AGGCTCACGCAAACATCAGGGCAAAGCACACACACACACAAAGAACCAGCAAGCGGTGAT
GAGGGCATCAAAGTATTGAAGCAACGTGCAAAGAAGAAACCAAACCCAGTAGAAGAGGAA
CCCAGCAGGAGAAGGCCAAGAGCACCTAAGGAAAAGGCCCAACCCCTGGAAGACCTGGCC
GGCTTCACAGAGCTCTCTGAAACATCAGGTCACACTCAGGAATCACTGACTGCTGGCAAA
GCCACTAAAATACCCTGCGAATCTCCCCCACTAGAAGTGGTAGACACCACAGCAAGCACA
AAGAGGCATCTCAGGACACGTGTGCAGAAGGTACAAGTAAAAGAAGAGCCTTCAGCAGTC
AAGTTCACACAAACATCAGGGGAAACCACGGATGCAGACAAAGAACCAGCAGGTGAAGAT
AAAGGCATCAAAGCATTGAAGGAATCTGCAAAACAGACACCGGCTCCAGCAGCAAGTGTA
ACTGGCAGCAGGAGACGGCCAAGAGCACCCAGGGAAAGTGCCCAAGCCATAGAAGACCTA
GCTGGCTTCAAAGACCCAGCAGCAGGTCACACTGAAGAATCAATGACTGATGACAAAACC
ACTAAAATACCCTGCAAATCATCACCAGAACTAGAAGACACCGCAACAAGCTCAAAGAGA
CGGCCCAGGACACGTGCCCAGAAAGTAGAAGTGAAGGAGGAGCTGTTAGCAGTTGGCAAG
CTCACACAAACCTCAGGGGAGACCACGCACACCGACAAAGAGCCGGTAGGTGAGGGCAAA
GGCACGAAAGCATTTAAGCAACCTGCAAAGCGGAAGCTGGACGCAGAAGATGTAATTGGC
AGCAGGAGACAGCCAAGAGCACCTAAGGAAAAGGCCCAACCCCTGGAAGATCTGGCCAGC
TTCCAAGAGCTCTCTCAAACACCAGGCCACACTGAGGAACTGGCAAATGGTGCTGCTGAT
AGCTTTACAAGCGCTCCAAAGCAAACACCTGACAGTGGAAAACCTCTAAAAATATCCAGA
AGAGTTCTTCGGGCCCCTAAAGTAGAACCCGTGGGAGACGTGGTAAGCACCAGAGACCCT
GTAAAATCACAAAGCAAAAGCAACACTTCCCTGCCCCCACTGCCCTTCAAGAGGGGAGGT
GGCAAAGATGGAAGCGTCACGGGAACCAAGAGGCTGCGCTGCATGCCAGCACCAGAGGAA
ATTGTGGAGGAGCTGCCAGCCAGCAAGAAGCAGAGGGTTGCTCCCAGGGCAAGAGGCAAA
TCATCCGAACCCGTGGTCATCATGAAGAGAAGTTTGAGGACTTCTGCAAAAAGAATTGAA
CCTGCGGAAGAGCTGAACAGCAACGACATGAAAACCAACAAAGAGGAACACAAATTACAA
GACTCGGTCCCTGAAAATAAGGGAATATCCCTGCGCTCCAGACGCCAAAATAAGACTGAG
GCAGAACAGCAAATAACTGAGGTCTTTGTATTAGCAGAAAGAATAGAAATAAACAGAAAT
GAAAAGAAGCCCATGAAGACCTCCCCAGAGATGGACATTCAGAATCCAGATGATGGAGCC
CGGAAACCCATACCTAGAGACAAAGTCACTGAGAACAAAAGGTGCTTGAGGTCTGCTAGA
CAGAATGAGAGCTCCCAGCCTAAGGTGGCAGAGGAGAGCGGAGGGCAGAAGAGTGCGAAG
GTTCTCATGCAGAATCAGAAAGGGAAAGGAGAAGCAGGAAATTCAGACTCCATGTGCCTG
AGATCAAGAAAGACAAAAAGCCAGCCTGCAGCAAGCACTTTGGAGAGCAAATCTGTGCAG
AGAGTAACGCGGAGTGTCAAGAGGTGTGCAGAAAATCCAAAGAAGGCTGAGGACAATGTG
TGTGTCAAGAAAATAAGAACCAGAAGTCATAGGGACAGTGAAGATATTTGA

Chromosome Location

10

Locus

10q26.2

External Identifiers

Resource	Link
UniProtKB ID	P46013
UniProtKB Entry Name	KI67_HUMAN
HGNC ID	HGNC:7107

General References

1. Schluter C, Duchrow M, Wohlenberg C, Becker MH, Key G, Flad HD, Gerdes J: The cell proliferation-associated antigen of antibody Ki-67: a very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins. J Cell Biol. 1993 Nov;123(3):513-22. doi: 10.1083/jcb.123.3.513. [Article]
2. Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE, Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H, Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S, Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E, Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C, Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK, Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE, McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J, Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK, Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T, Doucette-Stamm L, Beck S, Smith DR, Rogers J: The DNA sequence and comparative analysis of human chromosome 10. Nature. 2004 May 27;429(6990):375-81. [Article]
3. Gerdes J, Schwab U, Lemke H, Stein H: Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation. Int J Cancer. 1983 Jan 15;31(1):13-20. doi: 10.1002/ijc.2910310104. [Article]
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Drug Relations

Drug Relations

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