Phenylethylamine oxidase
Details
- Name
- Phenylethylamine oxidase
- Synonyms
- 1.4.3.21
- Primary amine oxidase
- Gene Name
- Not Available
- Organism
- Arthrobacter globiformis
- Amino acid sequence
>lcl|BSEQ0016576|Phenylethylamine oxidase MTPSTIQTASPFRLASAGEISEVQGILRTAGLLGPEKRIAYLGVLDPARGAGSEAEDRRF RVFIHDVSGARPQEVTVSVTNGTVISAVELDTAATGELPVLEEEFEVVEQLLATDERWLK ALAARNLDVSKVRVAPLSAGVFEYAEERGRRILRGLAFVQDFPEDSAWAHPVDGLVAYVD VVSKEVTRVIDTGVFPVPAEHGNYTDPELTGPLRTTQKPISITQPEGPSFTVTGGNHIEW EKWSLDVGFDVREGVVLHNIAFRDGDRLRPIINRASIAEMVVPYGDPSPIRSWQNYFDTG EYLVGQYANSLELGCDCLGDITYLSPVISDAFGNPREIRNGICMHEEDWGILAKHSDLWS GINYTRRNRRMVISFFTTIGNYDYGFYWYLYLDGTIEFEAKATGVVFTSAFPEGGSDNIS QLAPGLGAPFHQHIFSARLDMAIDGFTNRVEEEDVVRQTMGPGNERGNAFSRKRTVLTRE SEAVREADARTGRTWIISNPESKNRLNEPVGYKLHAHNQPTLLADPGSSIARRAAFATKD LWVTRYADDERYPTGDFVNQHSGGAGLPSYIAQDRDIDGQDIVVWHTFGLTHFPRVEDWP IMPVDTVGFKLRPEGFFDRSPVLDVPANPSQSGSHCHG
- Number of residues
- 638
- Molecular Weight
- 70645.405
- Theoretical pI
- 4.81
- GO Classification
- Functionsaliphatic-amine oxidase activity / aminoacetone / copper ion binding / phenethylamine / primary amine oxidase activity / quinone binding / tryptamineProcessesamine metabolic process
- General Function
- Tryptamine:oxygen oxidoreductase (deaminating) activity
- Specific Function
- Not Available
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0003627|1917 bp ATGACGCCCTCCACTATCCAAACAGCCAGCCCCTTCCGCCTTGCCTCAGCTGGGGAAATC AGTGAGGTGCAGGGCATTCTTCGGACCGCGGGCCTCCTTGGCCCGGAGAAGCGCATTGCC TACCTGGGCGTCCTTGACCCGGCCCGCGGCGCCGGCAGTGAAGCGGAAGACCGGCGCTTC CGGGTTTTCATCCACGACGTCTCCGGCGCCCGGCCCCAGGAAGTCACTGTCTCGGTCACC AACGGCACTGTGATCTCCGCCGTCGAACTCGATACCGCGGCCACCGGCGAACTGCCGGTC CTGGAAGAGGAGTTCGAGGTTGTGGAGCAACTGCTGGCCACCGACGAACGGTGGCTGAAG GCCCTGGCCGCCCGGAACCTTGACGTCAGCAAGGTGCGCGTTGCTCCGCTGTCCGCGGGT GTCTTCGAGTATGCGGAGGAGAGGGGCCGCCGGATCCTCCGCGGGCTTGCCTTCGTACAG GATTTTCCGGAGGACAGCGCTTGGGCTCATCCGGTTGACGGGCTGGTGGCCTACGTGGAC GTGGTCAGCAAGGAAGTCACCCGGGTGATCGACACCGGCGTCTTCCCCGTCCCGGCAGAG CACGGCAATTACACCGATCCCGAACTCACGGGTCCACTCCGCACCACCCAGAAACCCATC AGCATCACCCAGCCCGAAGGCCCCAGCTTCACGGTGACCGGCGGCAACCACATCGAATGG GAAAAATGGAGCCTGGACGTCGGCTTTGACGTCCGCGAGGGCGTGGTGCTGCACAACATT GCCTTCCGGGACGGGGACCGGCTCCGGCCCATCATCAACCGCGCGTCGATCGCCGAGATG GTGGTGCCGTACGGCGATCCGTCCCCGATCAGGTCCTGGCAGAACTACTTCGACACGGGG GAGTACCTGGTGGGCCAGTACGCCAACTCCCTCGAACTGGGCTGCGACTGCCTCGGCGAC ATCACCTACCTCAGCCCGGTCATCAGCGACGCCTTCGGCAACCCCCGCGAGATCCGCAAC GGCATCTGCATGCACGAGGAGGACTGGGGCATCCTGGCCAAGCACAGCGACCTTTGGTCC GGCATCAACTACACCCGCCGGAACCGCCGCATGGTGATCTCCTTCTTCACCACTATCGGC AACTACGACTACGGCTTCTACTGGTACCTCTACCTCGACGGCACCATCGAATTCGAAGCG AAAGCCACCGGCGTCGTCTTCACGTCCGCATTCCCGGAAGGCGGCTCGGACAACATTTCC CAGCTGGCACCGGGCCTGGGAGCGCCGTTCCACCAGCACATCTTCAGCGCCCGCCTGGAC ATGGCCATCGACGGCTTCACCAACAGGGTGGAGGAAGAGGACGTGGTCCGGCAAACCATG GGCCCGGGCAACGAGCGCGGCAACGCGTTCTCCCGAAAGCGCACCGTGCTGACCCGTGAG TCGGAGGCTGTCCGCGAGGCCGATGCCCGCACCGGCCGGACCTGGATCATCTCCAACCCC GAATCCAAGAACCGTCTCAACGAGCCGGTGGGCTACAAGCTGCACGCCCACAACCAGCCC ACCCTGCTGGCCGATCCCGGGTCCTCCATTGCGCGGCGGGCCGCCTTTGCCACCAAGGAC CTGTGGGTCACCCGCTACGCCGACGACGAGCGCTACCCCACCGGCGACTTCGTCAACCAG CACTCCGGCGGCGCGGGCCTGCCCTCCTACATCGCCCAGGACCGCGACATCGACGGCCAG GACATCGTCGTGTGGCACACCTTCGGACTGACCCACTTCCCGCGCGTGGAGGACTGGCCC ATCATGCCGGTGGACACCGTCGGCTTCAAGCTCCGTCCCGAGGGCTTCTTCGACCGCAGC CCGGTCCTCGATGTCCCGGCCAACCCCAGCCAGTCCGGCTCCCACTGCCACGGCTAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P46881 UniProtKB Entry Name PAOX_ARTGO - General References
- Tanizawa K, Matsuzaki R, Shimizu E, Yorifuji T, Fukui T: Cloning and sequencing of phenylethylamine oxidase from Arthrobacter globiformis and implication of Tyr-382 as the precursor to its covalently bound quinone cofactor. Biochem Biophys Res Commun. 1994 Mar 30;199(3):1096-102. [Article]
- Wilce MC, Dooley DM, Freeman HC, Guss JM, Matsunami H, McIntire WS, Ruggiero CE, Tanizawa K, Yamaguchi H: Crystal structures of the copper-containing amine oxidase from Arthrobacter globiformis in the holo and apo forms: implications for the biogenesis of topaquinone. Biochemistry. 1997 Dec 23;36(51):16116-33. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB02511 2-Hydroxy-5-({1-[(2-Naphthyloxy)Methyl]-3-Oxoprop-1-Enyl}Amino)Tyrosine experimental unknown Details DB02537 2-Hydroxy-5-({1-[(4-Methylphenoxy)Methyl]-3-Oxoprop-1-Enyl}Amino)-L-Tyrosine experimental unknown Details DB04334 6-hydroxydopa quinone experimental unknown Details DB06988 2-HYDROXY-5-{[(1E)-2-PHENYLETHYLIDENE]AMINO}-L-TYROSINE experimental unknown Details